Evaluation of Fractional CO2 Laser Treatment Efficacy and Comparison to Vaginal Conjugated Estrogen Cream in Postmenopausal Women with Vulvovaginal Atrophy: A Randomized Clinical Trial

Background: Vulvovaginal atrophy is common and bothersome among postmenopausal women. Hence in this study, the fractional CO2 laser treatment efficacy was compared with vaginal conjugated estrogen cream in postmenopausal women with vulvovaginal atrophy was assessed. Materials and Methods: In this randomized clinical trial, 130 consecutive postmenopausal women with vulvovaginal atrophy attending to urogynecologic clinic in Imam-Khomeini hospital in Ahvaz in 2015 were enrolled and were randomly assigned to receive either fractional CO2 laser treatment or vaginal conjugated estrogen cream. The improvement of vulvovaginal atrophy symptoms, sexual satisfaction and function were compared across the groups after 12 weeks. Results: There improvement of vulvovaginal atrophy symptoms, sexual satisfaction, and function were 86.2%, 87.7%, and 87.7%, respectively in laser group and 53.8%, 52.3%, and 52.3%, respectively in primarin group showing statistically significant differences (P=0.0001). There were no side effects. Conclusion: Totally, according to obtained results, it may be concluded that efficacy of fractional CO2 laser was higher than vaginal conjugated estrogen cream in postmenopausal women with vulvovaginal atrophy.

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Efficacy of fractional CO2 laser treatment in postmenopausal women with genitourinary syndrome

Menopause ◽

10.1097/gme.0000000000001428 ◽

2020 ◽

Vol 27 (1) ◽

pp. 43-49 ◽

Cited By ~ 5

Author(s):

Maurizio Filippini ◽

Daniela Luvero ◽

Stefano Salvatore ◽

Annalisa Pieralli ◽

Roberto Montera ◽

...

Keyword(s):

Postmenopausal Women ◽

Laser Treatment ◽

Co2 Laser ◽

Fractional Co2 Laser ◽

Co2 Laser Treatment ◽

Genitourinary Syndrome

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Fractional CO2 laser treatment for vulvovaginal atrophy in menopausal women

Maturitas ◽

10.1016/j.maturitas.2019.04.175 ◽

2019 ◽

Vol 124 ◽

pp. 177

Author(s):

Mafalda Martinho Simões ◽

Conceição Telhado ◽

Teresa Fraga

Keyword(s):

Laser Treatment ◽

Co2 Laser ◽

Fractional Co2 Laser ◽

Vulvovaginal Atrophy ◽

Menopausal Women ◽

Co2 Laser Treatment

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044 FSFI Assessment of Minimally invasive, Fractional CO2 laser treatment for Vulvovaginal Atrophy and Dyspareunia

Journal of Sexual Medicine ◽

10.1016/j.jsxm.2017.04.046 ◽

2017 ◽

Vol 14 (6) ◽

pp. e365-e366

Author(s):

S. Thomas ◽

R. Sifuentes

Keyword(s):

Minimally Invasive ◽

Laser Treatment ◽

Co2 Laser ◽

Fractional Co2 Laser ◽

Vulvovaginal Atrophy ◽

Co2 Laser Treatment

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The beneficial effects of fractional CO2 laser treatment on perineal changes during puerperium and breastfeeding period: a multicentric study

Lasers in Medical Science ◽

10.1007/s10103-020-03212-x ◽

2021 ◽

Author(s):

Daniela Luvero ◽

Maurizio Filippini ◽

Stefano Salvatore ◽

Annalisa Pieralli ◽

Miriam Farinelli ◽

...

Keyword(s):

Laser Treatment ◽

Co2 Laser ◽

Multicentric Study ◽

Fractional Co2 Laser ◽

Beneficial Effects ◽

Co2 Laser Treatment

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Early Regenerative Modifications of Human Postmenopausal Atrophic Vaginal Mucosa Following Fractional CO2 Laser Treatment

Open Access Macedonian Journal of Medical Sciences ◽

10.3889/oamjms.2018.058 ◽

2018 ◽

Vol 6 (1) ◽

pp. 6-14 ◽

Cited By ~ 14

Author(s):

Stefano Salvatore ◽

Katlein França ◽

Torello Lotti ◽

Marta Parma ◽

Sonia Palmieri ◽

...

Keyword(s):

Connective Tissue ◽

Laser Treatment ◽

Co2 Laser ◽

Vaginal Mucosa ◽

Structural Components ◽

Related Factors ◽

Fractional Co2 Laser ◽

Collagen Iii ◽

Co2 Laser Treatment ◽

Stimulation Of

BACKGROUND: Postmenopausal women experience undesired symptoms that adversely affect their quality of life. In the recent years, a specific 12 - week fractional CO2 laser treatment has been introduced, with highly significant relief of symptoms.AIM: The aim of this paper is the identification of the early modifications of structural components of atrophic vaginal mucosa induced by laser irradiation, which is responsible for the restorative processes.MATERIAL AND METHODS: We investigated by microscopical, ultrastructural and biochemical methods the modifications of the structural components of postmenopausal atrophic vaginal mucosa tissues after 1 hour following a single fractional laser CO2 application.RESULTS: In one hour, the mucosal epithelium thickens, with the maturation of epithelial cells and desquamation at the epithelial surface. In the connective tissue, new papillae indenting the epithelium with newly formed vessels penetrating them, new thin fibrils of collagen III are also formed in a renewed turnover of components due to the increase of metalloproteinase - 2. Specific features of fibroblasts support stimulation of their activity responsible of the renewal of the extracellular matrix, with an increase of mechanical support as connective tissue and stimulation of growth and maturation to epithelium thanks to new vessels and related factors delivered.CONCLUSION: We found the activation of regenerative mechanisms expressed both in the connective tissue - with the formation of new vessels, new papillae, and new collagen - and in the epithelium with the associated thickening and desquamation of cells at the mucosal surface.

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