scholarly journals Anticoagulant and vasodilator therapy for Nicolau syndrome following intramuscular benzathine penicillin injection in a 4 year old boy

2016 ◽  
Vol 114 (3) ◽  
Keyword(s):  
Benzathine Penicillin ◽  
Vasodilator Therapy ◽  
Nicolau Syndrome

scholarly journals Post-injection embolia cutis medicamentosa – Nicolau Syndrome: case report and literature review

2016 ◽  
Vol 15 (1) ◽  
pp. 70-73 ◽  
Author(s):  
Carlos Alberto Araujo Chagas ◽  
Tulio Fabiano de Oliveira Leite ◽  
Lucas Alves Sarmento Pires
Keyword(s):  
Healthcare Professionals ◽  
Subcutaneous Tissue ◽  
Vascular Complication ◽  
Benzathine Penicillin ◽  
Intense Pain ◽  
Large Ulcer ◽  
Intramuscular Injections ◽  
Nicolau Syndrome ◽  
Left Buttock ◽  
Embolia Cutis Medicamentosa

Abstract We report on the case of a 40-year-old male who was admitted to the clinic with a large ulcer on his left buttock, 3 days after an intramuscular benzathine penicillin injection. The patient was diagnosed with Nicolau syndrome, a rare vascular complication in which a lesion develops after intramuscular injection. Symptoms are intense pain at the injection site, erythema, and livedoid dermatitis, which leads to necrosis of skin, subcutaneous tissue and muscle tissue. It was described by Nicolau after intramuscular injections of bismuth salt for syphillis therapy. Nicolau syndrome is rare, but its symptoms are devastating and healthcare professionals must be aware of this clinical entity, since intramuscular injections are common procedures for administration of drugs.

scholarly journals Nicolau syndrome after intramuscular benzathine penicillin injection

2021 ◽  
Vol 64 ◽  
pp. 101597
Author(s):  
Yapo Guy serge Kouamé ◽  
Jean Baptiste Yaokreh ◽  
Moufidath Sounkeré ◽  
Samba Tembely ◽  
Idalia Taguela Ajoumissi ◽  
...  
Keyword(s):  
Benzathine Penicillin ◽  
Nicolau Syndrome

scholarly journals Nicolau syndrome following intramuscular benzathine penicillin injection: a case report

2020 ◽  
Vol 37 ◽  
Author(s):  
Walaza Phiri ◽  
Maen Shulammite Musonda ◽  
Kebby Kyakilika ◽  
Michelo Haluuma Miyoba ◽  
Malan Malumani
Keyword(s):  
Case Report ◽  
Benzathine Penicillin ◽  
Nicolau Syndrome

NICOLAU SYNDROME AFTER INTRAMUSCULAR BENZATHINE PENICILLIN TREATMENT

2006 ◽  
Vol 25 (8) ◽  
pp. 749 ◽  
Author(s):  
S??heyla Ocak ◽  
Baris Ekici ◽  
Halit ??am ◽  
Y??cel Ta&OV0613;tan
Keyword(s):  
Benzathine Penicillin ◽  
Nicolau Syndrome ◽  
Penicillin Treatment

Nicolau syndrome after benzathine penicillin treated with hyperbaric oxygen therapy

2014 ◽  
Vol 54 (4) ◽  
pp. e103-e106 ◽  
Author(s):  
Leonor Lopes ◽  
Susete Pires ◽  
Anabela Alves ◽  
Francisco Guerreiro ◽  
Paulo Filipe
Keyword(s):  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Benzathine Penicillin ◽  
Nicolau Syndrome

scholarly journals Nicolau syndrome following intramuscular benzathine penicillin

2008 ◽  
Vol 54 (4) ◽  
pp. 332 ◽  
Author(s):  
R De Sousa ◽  
A Dang ◽  
PV Rataboli
Keyword(s):  
Benzathine Penicillin ◽  
Nicolau Syndrome

scholarly journals Nicolau Syndrome due to Penicillin Injection: A Report of 3 Cases without Long-Term Complication

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Sara Memarian ◽  
Behdad Gharib ◽  
Mohammd Gharagozlou ◽  
Hosein Alimadadi ◽  
Zahra Ahmadinejad ◽  
...  
Keyword(s):  
Nerve Stimulation ◽  
Sympathetic Nerve ◽  
Clinical Symptoms ◽  
Rare Complication ◽  
Mechanical Injury ◽  
Benzathine Penicillin ◽  
Sympathetic Nerve Stimulation ◽  
Nicolau Syndrome

Nicolau syndrome (NS) or livedo-like dermatitis is a rare complication of injection of various medications such as penicillin. The pathophysiology of this events is not clear, but some hypotheses are suggested, such as sympathetic nerve stimulation, embolic occlusion, inflammation, or mechanical injury. In this paper we report 3 cases of NS following benzathine penicillin. Clinical symptoms improved in 2 cases during 2-month follow-up, but one of them had a residual necrosis in the distal phalanges of the toes.

NICOLAU SYNDROME DUE TO INTRAMUSCULAR DICLOFENAC SODIUM INJECTION

2020 ◽  
Vol 4 (2) ◽  
Author(s):  
Harris I Shaafie ◽  
Soumya Agarwal ◽  
Swosti Mohanty ◽  
Chandni Jain
Keyword(s):  
Standard Treatment ◽  
Rare Complication ◽  
Diclofenac Sodium ◽  
Tissue Necrosis ◽  
Cytotoxic Effects ◽  
Direct Damage ◽  
Nicolau Syndrome ◽  
Syndrome Diagnosis ◽  
Embolia Cutis Medicamentosa ◽  
Pigmentary Pattern

Nicolau syndrome (NS) is a rare complication characterized by tissue necrosis that occurs after parenteral injection of drugs. The exact pathogenesis is uncertain, but there are several hypotheses, including direct damage to the end artery, acute vasospasm and cytotoxic effects of the drug. Severe pain in the immediate post injection period and purplish discoloration of the skin with reticulate pigmentary pattern is characteristic of this syndrome. Diagnosis is mainly clinical and there is no standard treatment for the disease. Herein, we present a rare case of NS due to Diclofenac Sodium (Voltaren®) injection in an 80-year-old female suffering from Lower Respiratory Tract Infection (LRTI) who was managed conservatively. Keywords: Nicolau Syndrome, Embolia cutis medicamentosa, Voltaren, Diclofenac sodium

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