scholarly journals Traditional and Nontraditional Cardiovascular Risk Factors in Comorbid Insomnia and Sleep Apnea

SLEEP ◽  
2014 ◽  
Vol 37 (3) ◽  
pp. 593-600 ◽  
Author(s):  
Faith S. Luyster ◽  
Kevin E. Kip ◽  
Daniel J. Buysse ◽  
Aryan N. Aiyer ◽  
Steven E. Reis ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Sleep Apnea ◽  
Cardiovascular Risk Factors ◽  
Comorbid Insomnia

scholarly journals MON-284 Systematic Screening Reveals Large Number of Undiagnosed and Untreated Cardiovascular Risk Factors in Adults with Prader-Willi Syndrome

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Karlijn Pellikaan ◽  
Anna Gerarda Wilhelmina Rosenberg ◽  
Janneke Baan ◽  
Kirsten Davidse ◽  
Aart Jan Van der Lely ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Sleep Apnea ◽  
Energy Expenditure ◽  
Cardiovascular Risk Factors ◽  
Health Problems ◽  
Low Energy ◽  
Exercise Intolerance ◽  
Prader Willi Syndrome ◽  
Systematic Screening

Abstract Introduction: Prader-Willi syndrome (PWS) is a complex hypothalamic disorder, combining hypotonia, intellectual disability (ID), pituitary hormone deficiencies and hyperphagia. In PWS, up to 3% of patients die every year. In half of the patients, the cause of death is obesity related and / or of cardiovascular (CV) origin. Obesity is caused by hyperphagia combined with a low energy expenditure. Untreated hormone deficiencies like hypogonadism and hypothyroidism can cause low muscle mass and low basal rest metabolism (BRM) leading to this low energy expenditure. Patients with PWS should exercise one hour daily to compensate for their low BRM. However, hormone deficiencies usually cause fatigue, leading to exercise intolerance. Musculoskeletal and / or behavioral problems can also cause reduced physical activity. The subsequent sedentary lifestyle can induce CV risk factors like hypertension, hypercholesterolemia and diabetes mellitus (DM). Another risk factor often present in PWS is sleep apnea, which can be central (CSA), obstructive (OSA) or both. Both CSA and OSA can lead to pulmonary hypertension and a further increase in obesity. The above mentioned health problems often remain unnoticed and untreated, which is partly due to the behavioral phenotype of PWS (patients seldomly report pain and hardly ever complain about physical problems). However, if left untreated, these risk factors can cause CV complications leading to hospital admission or even death. To reveal yet undiagnosed health problems, we performed a systematic health screening among adults with PWS. Methods: We systematically screened 115 adults with PWS (mean age 31.4 ± 12.1 y, mean BMI 31.8 ± 9,5 kg/m2) for the presence of undiagnosed health problems and cardiovascular risk factors. Based on a medical questionnaire, medical file search, extensive interview, thorough physical examination and biochemical measurements we made an overview of the undiagnosed health problems in adults with PWS. If possible, we performed polygraphy to test for sleep apnea. Results: Undiagnosed health problems (hypertension, DM, hypercholesterolemia, sleep apnea, hypothyroidism and hypogonadism) were present in 50% of the patients. 10% had multiple undiagnosed health problems simultaneously. All males and 94% of females had hypogonadism and 15% had hypothyroidism. Hypertension and / or hypercholesterolemia were present in 20% and DM was present in 16%. One third of patients was not on a diet and 22% exercised less than 30 minutes a day. Sleep apnea was present in 17 of 26 patients tested. Conclusion: We detected a striking number of undiagnosed health problems among adults with PWS which, if left untreated, can pose a serious health threat. Systematic screening is needed to detect these problems in an early phase. This will prevent burdensome and expensive complications and might even reduce mortality in this vulnerable patient population.

scholarly journals A Prospective Study of CPAP Therapy in Relation to Cardiovascular Outcome in a Cohort of Romanian Obstructive Sleep Apnea Patients

2021 ◽  
Vol 11 (10) ◽  
pp. 1001
Author(s):  
Ioana Maria Chetan ◽  
Anca Diana Maierean ◽  
Bianca Domokos Gergely ◽  
Georgiana Cabau ◽  
Raluca Tomoaia ◽  
...  
Keyword(s):  
Risk Factors ◽  
Obstructive Sleep Apnea ◽  
Cardiovascular Risk ◽  
Sleep Apnea ◽  
Cardiovascular Risk Factors ◽  
Cardiovascular Outcome ◽  
Cpap Therapy ◽  
Obstructive Sleep ◽  
One Year

Background: Despite efforts at treatment, obstructive sleep apnea (OSA) remains a major health problem, especially with increasing evidence showing an association with cardiovascular morbidity and mortality. The treatment of choice for OSA patients is Continuous Positive Airway Pressure (CPAP), which has been proven in randomized controlled trials to be an effective therapy for this condition. The impact of CPAP on the cardiovascular pathology associated with OSA remains, however, unclear. Although the effect of CPAP has been previously studied in relation to cardiovascular outcome, follow-up of the treatment impact on cardiovascular risk factors at one year of therapy is lacking in a Romanian population. Thus, we aimed to evaluate the one-year effect of CPAP therapy on lipid profile, inflammatory state, blood pressure and cardiac function, assessed by echocardiography, on a cohort of Romanian OSA patients. Methods: We enrolled 163 participants and recorded their baseline demographic and clinical characteristics with a follow-up after 12 months. Inflammatory and cardiovascular risk factors were assessed at baseline and follow up. Results: Our results show that CPAP therapy leads to attenuation of cardiovascular risk factors including echocardiographic parameters, while having no effect on inflammatory markers. Conclusion: Treatment of OSA with CPAP proved to have beneficial effects on some of the cardiovascular risk factors while others remained unchanged, raising new questions for research into the treatment and management of OSA patients.

Abstract 16094: Association of Diurnal Blood Pressure Variation and Nocturnal Hypoxia in Patients With Cardiovascular Risk Factors: Japan Morning Surge-Home Blood Pressure (J-HOP) SAS Study

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Masahisa Shimpo ◽  
Satoshi Hoshide ◽  
Michiaki Nagai ◽  
Kazuo Eguchi ◽  
Kazuomi Kario
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Cardiovascular Risk ◽  
Sleep Apnea ◽  
Cardiovascular Risk Factors ◽  
Large Scale ◽  
Target Organ Damage ◽  
Sleep Apnea Syndrome ◽  
Risk Increase ◽  
Severe Sleep Apnea

Introduction: Abnormal diurnal blood pressure (BP) variation, such as riser or extreme-dipper, is known as risk factors of target organ damage and subsequent cardiovascular events. Nocturnal hypoxia due to sleep apnea syndrome (SAS) is likely to influence diurnal BP variation and risk increase; however, little has been evaluated in large scale cohort in Asian population. Hypothesis: We assessed the hypothesis that diurnal BP variation is associated with nocturnal hypoxia in high risk Japanese patients. Methods: The study subjects were 1087 participants of the J-HOP Study with one or more cardiovascular risk factors (n=4019). Pulse oximetry oxygen saturation (SpO2) was measured with a validated device (PULSOX Me-300; Teijin Pharma, Tokyo, Japan) simultaneously with ambulatory BP monitoring (ABPM). Results: The frequency of each diurnal BP variation are as follows; dipper (normal circadian rhythm) 42.8%, non-dippers 34.6%, extreme-dipper 13.2%, riser 9.4%. When assessed by 3% oxygen desaturation index (ODI; times/h), 14.2% of patients showed 3%ODI≥15 (suspected moderate sleep apnea), and 2.8% of patients showed 3%ODI≥30 (suspected severe sleep apnea). The likelihood of coexisting severe sleep apnea (3%ODI≥30) was significantly higher (5.9%) in patients with riser pattern compared with that in dipper pattern (1.9%) (odd ratio 3.17; 95%CI 1.10-9.11, p<0.03). Three percent ODI was significantly higher in patients with riser pattern than that in dipper pattern (6.6 vs 5.1 times/h; p=0.01). Furthermore, the patients in the longest time spent with SpO2 <90% category in quintiles had an increased likelihood of extreme-dipper pattern compared with those in the shorter categories (odds ratio 1.71; 95%CI 1.10-2.65; p<0.03). Conclusion: Abnormal diurnal BP variation was associated with nocturnal hypoxia in patients with cardiovascular risk factors. For the patients with riser or extreme-dipper pattern, further evaluations are recommended to detect higher risk patients with nocturnal hypoxia, such as SAS, heart failure or chronic pulmonary diseases.

Prevalence of sleep apnea and cardiovascular risk factors in patients with hypertension in a day hospital model

2017 ◽  
Vol 40 (3) ◽  
pp. 231-237 ◽  
Author(s):  
Eduardo Borsini ◽  
Magalí Blanco ◽  
Martín Bosio ◽  
Marcela Schrappe ◽  
Glenda Ernst ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Sleep Apnea ◽  
Cardiovascular Risk Factors ◽  
Day Hospital

Traditional cardiovascular risk factors but not homocysteine are associated with obstructive sleep apnea

2006 ◽  
Vol 26 (2) ◽  
pp. 59-64 ◽  
Author(s):  
Chien-Hsiang Cheng ◽  
Men-Chung Huang ◽  
Shao-Chun Liu ◽  
Keh-Liang Lin ◽  
Yi-Chia Huang
Keyword(s):  
Risk Factors ◽  
Obstructive Sleep Apnea ◽  
Cardiovascular Risk ◽  
Sleep Apnea ◽  
Cardiovascular Risk Factors ◽  
Obstructive Sleep

Adiposity and Cardiovascular Risk Factors in Men With Obstructive Sleep Apnea

CHEST Journal ◽  
1993 ◽  
Vol 103 (5) ◽  
pp. 1336-1342 ◽  
Author(s):  
Paul D. Levinson ◽  
Stephen T. McGarvey ◽  
Carol C. Carlisle ◽  
Scott E. Eveloff ◽  
Peter N. Herbert ◽  
...  
Keyword(s):  
Risk Factors ◽  
Obstructive Sleep Apnea ◽  
Cardiovascular Risk ◽  
Sleep Apnea ◽  
Cardiovascular Risk Factors ◽  
Obstructive Sleep

L0059 Menopause and cardiovascular risk factors in sleep apnea

2007 ◽  
Vol 8 ◽  
pp. S112
Author(s):  
N. Dursunoglu ◽  
L. Grote ◽  
H. Becker ◽  
J. Hedner ◽  
J.H. Peter
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Sleep Apnea ◽  
Cardiovascular Risk Factors
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