Protection against recurrent acute bronchitis after oral immunization with killed Haemophilus influenzae

1990 ◽  
Vol 152 (8) ◽  
pp. 413-416 ◽  
Author(s):  
Robert L Clancy ◽  
Allan W Cripps ◽  
Val Gebski
Keyword(s):  
Haemophilus Influenzae ◽  
Acute Bronchitis ◽  
Oral Immunization

Efficacy of oral immunization against non-typable Haemophilus influenzae in man

1987 ◽  
Vol 9 (3) ◽  
pp. 283-288 ◽  
Author(s):  
S. Yeung ◽  
G. Pang ◽  
A.W. Cripps ◽  
R.L. Clancy ◽  
J.H. Wlodarczyk
Keyword(s):  
Haemophilus Influenzae ◽  
Oral Immunization

Ultrastructural studies on the interaction of haemophilus influenzae with human endothelial cells in vitro

1990 ◽  
Vol 48 (3) ◽  
pp. 636-637
Author(s):  
D.J.P. Ferguson ◽  
M. Virji ◽  
H. Kayhty ◽  
E.R. Moxon
Keyword(s):  
Endothelial Cells ◽  
Haemophilus Influenzae ◽  
Intercellular Junctions ◽  
Blood Stream ◽  
Ultrastructural Studies ◽  
Endothelial Barriers ◽  
Serotype B ◽  
Meningitis In Children ◽  
Respiratory Epithelial

Haemophilus influenzae is a human pathogen which causes meningitis in children. Systemic H. influenzae infection is largely confined to encapsulated serotype b organisms and is a major cause of meningitis in the U.K. and elsewhere. However, the pathogenesis of the disease is still poorly understood. Studies in the infant rat model, in which intranasal challenge results in bacteraemia, have shown that H. influenzae enters submucosal tissues and disseminates to the blood stream within minutes. The rapidity of these events suggests that H. influenzae penetrates both respiratory epithelial and endothelial barriers with great efficiency. It is not known whether the bacteria penetrate via the intercellular junctions, are translocated within the cells or carried across the cellular barrier in 'trojan horse' fashion within phagocytes. In the present studies, we have challenged cultured human umbilical cord_vein endothelial cells (HUVECs) with both capsulated (b+) and capsule-deficient (b-) isogenic variants of one strain of H. influenzae in order to investigate the interaction between the bacteria and HUVEC and the effect of the capsule.

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