Liver failure associated with the use of black cohosh for menopausal symptoms

2008 ◽  
Vol 188 (7) ◽  
pp. 420-422 ◽  
Author(s):  
Elizabeth C‐Y Chow ◽  
Marcus Teo ◽  
John A Ring ◽  
John W Chen
Keyword(s):  
Liver Failure ◽  
Menopausal Symptoms ◽  
Black Cohosh

Liver failure associated with the use of black cohosh for menopausal symptoms

2009 ◽  
Vol 190 (2) ◽  
pp. 99-100 ◽  
Author(s):  
Elizabeth C‐Y Chow ◽  
Marcus Teo ◽  
John A Ring ◽  
John W Chen
Keyword(s):  
Liver Failure ◽  
Menopausal Symptoms ◽  
Black Cohosh

scholarly journals Black cohosh (Actaea racemosa) for the mitigation of menopausal symptoms: recent developments in clinical safety and efficacy

2006 ◽  
Vol 2 (5) ◽  
pp. 773-783 ◽  
Author(s):  
Gail B Mahady ◽  
Brian Doyle ◽  
Tracie Locklear ◽  
Scott J Cotler ◽  
Grace Guzman-Hartman ◽  
...  
Keyword(s):  
Menopausal Symptoms ◽  
Black Cohosh ◽  
Clinical Safety ◽  
Safety And Efficacy ◽  
Actaea Racemosa ◽  
Recent Developments

scholarly journals Review & meta-analysis: isopropanolic black cohosh extract iCR for menopausal symptoms – an update on the evidence

Climacteric ◽  
2020 ◽  
pp. 1-11
Author(s):  
C. Castelo-Branco ◽  
M. Gambacciani ◽  
A. Cano ◽  
M. J. Minkin ◽  
D. Rachoń ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Menopausal Symptoms ◽  
Black Cohosh

Acute liver failure associated with the use of herbal preparations containing black cohosh

2003 ◽  
Vol 179 (7) ◽  
pp. 390-391 ◽  
Author(s):  
Steve Lontos ◽  
Robert M Jones ◽  
Peter W Angus ◽  
Paul J Gow
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Black Cohosh ◽  
Herbal Preparations

scholarly journals Black Cohosh: Insights into its Mechanism(s) of Action

2008 ◽  
Vol 3 ◽  
pp. 117863370800300 ◽  
Author(s):  
Rachel L. Ruhlen ◽  
Grace Y. Sun ◽  
Edward R. Sauter
Keyword(s):  
Breast Cancer ◽  
Disease Risk ◽  
Hormone Replacement ◽  
Cardiovascular Disease Risk ◽  
Menopausal Symptoms ◽  
Black Cohosh ◽  
Preclinical Studies ◽  
Nitric Oxide Production ◽  
Health Initiative ◽  
Receptor Modulator

The Women's Health Initiative found that combination estrogen and progesterone hormone replacement therapy increases breast cancer and cardiovascular disease risk, which compelled many women to seek herbal alternatives such as black cohosh extract (BCE) to relieve their menopausal symptoms. While several clinical trials document the efficacy of BCE in alleviating menopausal symptoms, preclinical studies to determine how BCE works have yielded conflicting results. Part of this is because there is not a universally accepted method to standardize the dose of black cohosh triterpenes, the presumed active ingredients in the extract. Although the mechanism by which BCE relieves symptoms is unknown, several hypotheses have been proposed: it acts 1) as a selective estrogen receptor modulator, 2) through serotonergic pathways, 3) as an antioxidant, or 4) on inflammatory pathways. We found that while the most prominent triterpene in BCE, 23-epi-26-deoxyactein, suppresses cytokine-induced nitric oxide production in brain microglial cells, the whole BCE extract actually enhanced this pathway. A variety of activities have been reported for black cohosh and its compounds, but the absorption and tissue distribution of these compounds is unknown.

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