scholarly journals A Simple and Efficient Synthesis of Tertiary Alcohols via Ta2O5- Catalyzed Barbier-Grignard Addition of Unactivated Aryl Bromides to Aryl Acids

2016 ◽  
Vol 36 (10) ◽  
pp. 2456 ◽  
Author(s):  
Huaran Wang ◽  
Yu Tang ◽  
Jun Yang ◽  
Yuanming Zhang
Keyword(s):  
Efficient Synthesis ◽  
Tertiary Alcohols ◽  
Aryl Bromides ◽  
Grignard Addition

scholarly journals Microwave-assisted Efficient Synthesis of Alliodorin and (±)-Curcuhydroquinone

1999 ◽  
Vol 23 (2) ◽  
pp. 164-165
Author(s):  
Goverdhan L. Kad ◽  
Anupam Khurana ◽  
Vasundhara Singh ◽  
Jasvinder Singh
Keyword(s):  
Grignard Reagents ◽  
Methyl Groups ◽  
Efficient Synthesis ◽  
Alkyl Aryl ◽  
Microwave Assisted ◽  
Aryl Bromides ◽  
Key Steps

Terpenoids 1 and 2 have been synthesized from readily available starting materials using Li2CuCI4-catalysed coupling of Grignard reagents with alkyl/aryl bromides and microwave-assisted oxidation of allylic methyl groups, using SeO2/ButOOH adsorbed over SiO2 as key steps.

scholarly journals Electroreductive Olefin-Ketone Coupling

2020 ◽  
Author(s):  
Pengfei Hu ◽  
Byron Peters ◽  
Christian A. Malapit ◽  
Julien Vantourout ◽  
Pan Wang ◽  
...  
Keyword(s):  
Mechanistic Studies ◽  
Tertiary Alcohols ◽  
Electrochemical Approach ◽  
Grignard Addition ◽  
User Friendly

<div><div><div><p>A user-friendly approach to sidestep the venerable Grignard addition to unactivated ketones to access tertiary alcohols by reversing the polarity of the disconnection. In this work a ketone instead acts as a nucleophile when adding to simple unactivated olefins to accomplish the same overall transformation. The scope of this coupling is broad as enabled using an electrochemical approach and the reaction is scalable, chemoselective, and requires no precaution to exclude air or water. Multiple applications demonstrate the simplifying nature of the reaction on multi-step synthesis and mechanistic studies point to an intuitive mechanism reminiscent of other chemical reductants such as SmI2 (which cannot accomplish the same reaction).</p></div></div></div>

ChemInform Abstract: Pd-Catalyzed Intramolecular Acylation of Aryl Bromides via C-H Functionalization: A Highly Efficient Synthesis of Benzocyclobutenones.

ChemInform ◽  
2010 ◽  
Vol 41 (28) ◽  
pp. no-no
Author(s):  
Paula Alvarez-Bercedo ◽  
Areli Flores-Gaspar ◽  
Arkaitz Correa ◽  
Ruben Martin
Keyword(s):  
Efficient Synthesis ◽  
Highly Efficient ◽  
Aryl Bromides

Efficient synthesis of an α-trifluoromethyl-α-tosyloxymethyl epoxide enabling stepwise double functionalisation to afford CF3-substituted tertiary alcohols

2008 ◽  
Vol 49 (34) ◽  
pp. 5101-5104 ◽  
Author(s):  
Steven P. Keeling ◽  
Ian B. Campbell ◽  
Diane M. Coe ◽  
Tony W.J. Cooper ◽  
George W. Hardy ◽  
...  
Keyword(s):  
Efficient Synthesis ◽  
Tertiary Alcohols

scholarly journals Efficient synthesis of π-conjugated molecules incorporating fluorinated phenylene units through palladium-catalyzed iterative C(sp2)–H bond arylations

2015 ◽  
Vol 11 ◽  
pp. 2012-2020 ◽  
Author(s):  
Fatiha Abdelmalek ◽  
Fazia Derridj ◽  
Safia Djebbar ◽  
Jean-François Soulé ◽  
Henri Doucet
Keyword(s):  
Conjugated Oligomers ◽  
Efficient Synthesis ◽  
Conjugated Molecules ◽  
Direct Arylation ◽  
Heteroaromatic Compounds ◽  
Aryl Bromides ◽  
Palladium Catalyzed ◽  
High Yields

We report herein a two or three step synthesis of fluorinated π-conjugated oligomers through iterative C–H bond arylations. Palladium-catalyzed desulfitative arylation of heteroarenes allowed in a first step the synthesis of fluoroaryl-heteroarene units in high yields. Then, the next steps involve direct arylation with aryl bromides catalyzed by PdCl(C3H5)(dppb) to afford triad or tetrad heteroaromatic compounds via regioselective activation of C(sp2)–H bonds.

Pd-Catalyzed Intramolecular Acylation of Aryl Bromides via C−H Functionalization: A Highly Efficient Synthesis of Benzocyclobutenones

2010 ◽  
Vol 132 (2) ◽  
pp. 466-467 ◽  
Author(s):  
Paula Álvarez-Bercedo ◽  
Areli Flores-Gaspar ◽  
Arkaitz Correa ◽  
Ruben Martin
Keyword(s):  
Efficient Synthesis ◽  
Highly Efficient ◽  
Aryl Bromides
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