scholarly journals The effect of continuous positive airway pressure on blood pressure in patients with obstructive sleep apnea and uncontrolled hypertension - Study design and challenges during the COVID-19 pandemic

Clinics ◽  
2021 ◽  
Vol 76 ◽  
Author(s):  
Fernanda C.S.G. Cruz ◽  
Luciano F. Drager ◽  
Daniel B.C. Queiróz ◽  
Gabriela A. Souza ◽  
Rodrigo P. Pedrosa ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Continuous Positive Airway Pressure ◽  
Study Design ◽  
Airway Pressure ◽  
Positive Airway Pressure ◽  
Uncontrolled Hypertension ◽  
Obstructive Sleep

Effects of continuous positive airway pressure on blood pressure in hypertensive patients with obstructive sleep apnea

2013 ◽  
Vol 31 (2) ◽  
pp. 352-360 ◽  
Author(s):  
Alexandros Kasiakogias ◽  
Costas Tsioufis ◽  
Costas Thomopoulos ◽  
Dimitrios Aragiannis ◽  
Manos Alchanatis ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Continuous Positive Airway Pressure ◽  
Airway Pressure ◽  
Positive Airway Pressure ◽  
Hypertensive Patients ◽  
Obstructive Sleep

Effects of nasal continuous positive airway pressure and oxygen supplementation on norepinephrine kinetics and cardiovascular responses in obstructive sleep apnea

2006 ◽  
Vol 100 (1) ◽  
pp. 343-348 ◽  
Author(s):  
Paul J. Mills ◽  
Brian P. Kennedy ◽  
Jose S. Loredo ◽  
Joel E. Dimsdale ◽  
Michael G. Ziegler
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Continuous Positive Airway Pressure ◽  
Release Rate ◽  
Airway Pressure ◽  
Positive Airway Pressure ◽  
Oxygen Supplementation ◽  
Obstructive Sleep

Obstructive sleep apnea (OSA) is characterized by noradrenergic activation. Nasal continuous positive airway pressure (CPAP) is the treatment of choice and has been shown to effectively reduce elevated norepinephrine (NE) levels. This study examined whether the reduction in NE after CPAP is due to an increase in NE clearance and/or a decrease of NE release rate. Fifty CPAP-naive OSA patients with an apnea-hypopnea index >15 were studied. NE clearance and release rates, circulating NE levels, urinary NE excretion, and blood pressure and heart rate were determined before and after 14 days of CPAP, placebo CPAP (CPAP administered at ineffective pressure), or oxygen supplementation. CPAP led to a significant increase in NE clearance ( P ≤ 0.01), as well as decreases in plasma NE levels ( P ≤ 0.018) and daytime ( P < 0.001) and nighttime ( P < 0.05) NE excretion. NE release rate was unchanged with treatment. Systolic ( P ≤ 0.013) and diastolic ( P ≤ 0.026) blood pressure and heart rate ( P ≤ 0.014) were decreased in response to CPAP but not in response to oxygen or placebo CPAP treatment. Posttreatment systolic blood pressure was best predicted by pretreatment systolic blood pressure and posttreatment NE clearance and release rate ( P < 0.01). The findings indicate that one of the mechanisms through which CPAP reduces NE levels is through an increase in the clearance of NE from the circulation.

scholarly journals Blood Pressure Improvement with Continuous Positive Airway Pressure is Independent of Obstructive Sleep Apnea Severity

2014 ◽  
Vol 10 (04) ◽  
pp. 365-369 ◽  
Author(s):  
Jessie P. Bakker ◽  
Bradley A. Edwards ◽  
Shiva P. Gautam ◽  
Sydney B. Montesi ◽  
Joaquín Durán-Cantolla ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Continuous Positive Airway Pressure ◽  
Airway Pressure ◽  
Positive Airway Pressure ◽  
Obstructive Sleep Apnea Severity ◽  
Obstructive Sleep
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