Effect of use of insulin pump with low glucose suspend feature on metabolic control in children with type 1diabetes

Introduction. The automatic suspension of the insulin pump and discontinuationof insulin delivery in case of hypoglycemia is one of the features ofVeo insulin pump when it is connected with the sensor used for continuousmonitoring of glycemia (CGM). This type of therapy is currently consideredto be the best one for achieving a good metabolic control in children withtype 1 diabetes mellitus. The objective of the study was to check whetherthe use of an option for automatic suspension in case of hypoglycemia andcombined bolus affects the metabolic control in children with type 1 diabetesmellitus using the insulin pump for a three-month period.Methods. The study included 25 participants (13 girls and 12 boys), aged7 to 15 years with average age 11.88 ± 3.15 years and average diabetes durationof 6.12 ± 2.5 years. On average, the participants have already beenusing the insulin pump Paradigm Veo TM MMT-754 for 3.08 ± 1.73 years.The measurements of HbA1c were done at the beginning of the study, thenafter three and six months.Results. The percentage of glucose serum levels above 7.8 mmol/L insignificantlyincreased, while the percentage of glucose serum levels below3.9 mmol/L decreased during the three-month period of CGM wearing.The initial HbA1c was 7.53 ± 0.87%. After three months of wearing, CGMHbA1c showed a slight decrease to 7.48 ± 0.73%, while at the follow-up afteranother three months without CGM HbA1c increased to 7.57 ± 0.98%.Conclusion. This study shows that the use of an insulin pump with the optionof automatic suspension in case of hypoglycemia and combined bolusis only associated with a certain improvement in the metabolic controlafter three months of continuous wearing without increasing the risk ofhypoglycemia.