scholarly journals Peer Review #3 of "Developmental toxicity from exposure to various forms of mercury compounds in medaka fish (Oryzias latipes) embryos (v0.3)"

2016 ◽  
Keyword(s):  
Peer Review ◽  
Developmental Toxicity ◽  
Oryzias Latipes ◽  
Medaka Fish ◽  
Mercury Compounds

scholarly journals Developmental toxicity from exposure to various forms of mercury compounds in medaka fish (Oryzias latipes) embryos

2016 ◽  
Author(s):  
Wu Dong ◽  
Jie Liu ◽  
Lixin Wei ◽  
Yang Jingfeng ◽  
Melissa Chernick ◽  
...  
Keyword(s):  
Developmental Toxicity ◽  
Inorganic Mercury ◽  
Oryzias Latipes ◽  
Heme Oxygenase 1 ◽  
Organic Form ◽  
Traditional Medicines ◽  
Mercury Compounds ◽  
Pericardial Edema ◽  
Eye Pigmentation ◽  
Swim Bladder Inflation

This study examined developmental toxicity of different mercury compounds, including some used in traditional medicines. Medaka (Oryzias latipes) embryos were exposed to 0.001-10 μM concentrations of MeHg, HgCl2, α-HgS (Zhu Sha), and β-HgS (Zuotai) from stage 10 (6-7 hpf) to 10 days post fertilization (dpf). Of the forms of mercury in this study, the organic form (MeHg) proved the most toxic followed by inorganic mercury (HgCl2), both producing embryo developmental toxicity. Altered phenotypes included pericardial edema with elongated or tube heart, reduction of eye pigmentation, and failure of swim bladder inflation. Both α-HgS and β-HgS were less toxic than MeHg and HgCl2. Total RNA was extracted from survivors 3 days after exposure to MeHg (0.1 μM), HgCl2 (1 μM), α-HgS (10 μM), or β-HgS (10 μM) to examine toxicity-related gene expression. MeHg and HgCl2 markedly induced metallothionein (MT) and heme oxygenase-1 (Ho-1), while α-HgS and β-HgS failed to induce either gene. Chemical forms of mercury compounds proved to be a major determinant in their developmental toxicity.

scholarly journals Developmental toxicity from exposure to various forms of mercury compounds in medaka fish (Oryzias latipes) embryos

2016 ◽  
Author(s):  
Wu Dong ◽  
Jie Liu ◽  
Lixin Wei ◽  
Yang Jingfeng ◽  
Melissa Chernick ◽  
...  
Keyword(s):  
Developmental Toxicity ◽  
Inorganic Mercury ◽  
Oryzias Latipes ◽  
Heme Oxygenase 1 ◽  
Organic Form ◽  
Traditional Medicines ◽  
Mercury Compounds ◽  
Pericardial Edema ◽  
Eye Pigmentation ◽  
Swim Bladder Inflation

This study examined developmental toxicity of different mercury compounds, including some used in traditional medicines. Medaka (Oryzias latipes) embryos were exposed to 0.001-10 μM concentrations of MeHg, HgCl2, α-HgS (Zhu Sha), and β-HgS (Zuotai) from stage 10 (6-7 hpf) to 10 days post fertilization (dpf). Of the forms of mercury in this study, the organic form (MeHg) proved the most toxic followed by inorganic mercury (HgCl2), both producing embryo developmental toxicity. Altered phenotypes included pericardial edema with elongated or tube heart, reduction of eye pigmentation, and failure of swim bladder inflation. Both α-HgS and β-HgS were less toxic than MeHg and HgCl2. Total RNA was extracted from survivors 3 days after exposure to MeHg (0.1 μM), HgCl2 (1 μM), α-HgS (10 μM), or β-HgS (10 μM) to examine toxicity-related gene expression. MeHg and HgCl2 markedly induced metallothionein (MT) and heme oxygenase-1 (Ho-1), while α-HgS and β-HgS failed to induce either gene. Chemical forms of mercury compounds proved to be a major determinant in their developmental toxicity.

scholarly journals Developmental toxicity from exposure to various forms of mercury compounds in medaka fish (Oryzias latipes) embryos

PeerJ ◽  
2016 ◽  
Vol 4 ◽  
pp. e2282 ◽  
Author(s):  
Wu Dong ◽  
Jie Liu ◽  
Lixin Wei ◽  
Yang Jingfeng ◽  
Melissa Chernick ◽  
...  
Keyword(s):  
Developmental Toxicity ◽  
Inorganic Mercury ◽  
Oryzias Latipes ◽  
Heme Oxygenase 1 ◽  
Organic Form ◽  
Traditional Medicines ◽  
Mercury Compounds ◽  
Pericardial Edema ◽  
Eye Pigmentation ◽  
Swim Bladder Inflation

This study examined developmental toxicity of different mercury compounds, including some used in traditional medicines. Medaka (Oryzias latipes) embryos were exposed to 0.001–10 µM concentrations of MeHg, HgCl2,α-HgS (Zhu Sha), andβ-HgS (Zuotai) from stage 10 (6–7 hpf) to 10 days post fertilization (dpf). Of the forms of mercury in this study, the organic form (MeHg) proved the most toxic followed by inorganic mercury (HgCl2), both producing embryo developmental toxicity. Altered phenotypes included pericardial edema with elongated or tube heart, reduction of eye pigmentation, and failure of swim bladder inflation. Bothα-HgS andβ-HgS were less toxic than MeHg and HgCl2. Total RNA was extracted from survivors three days after exposure to MeHg (0.1 µM), HgCl2(1 µM),α-HgS (10 µM), orβ-HgS (10 µM) to examine toxicity-related gene expression. MeHg and HgCl2markedly induced metallothionein (MT) and heme oxygenase-1 (Ho-1), whileα-HgS andβ-HgS failed to induce either gene. Chemical forms of mercury compounds proved to be a major determinant in their developmental toxicity.

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