Previous studies found that valence (positive vs negative vs neutral) and visual half-field (left versus right) have an influence on word reading: Words are processed more efficiently when they evoke positive feelings and when they appear in the right visual field. In the present study we tried to address previous (contradictory) reports of an interaction between valence and visual half-field. A group of 39 right-handed undergraduates completed a lexical decision task in their native language (Dutch). They responded to 300 trials with real words (50 words per valence category - positive, negative, neutral – presented once in the left visual half-field and once in the right half-field) and 300 trials with non-words. Overall, participants responded more efficiently to positive words and there was a strong right visual field advantage. We did not find a significant interaction, however. Further analysis indicated that to find a replicable interaction between a stimulus characteristic and visual half-field, one requires much high numbers of participants and stimuli than done so far (and more than most researchers would be willing to invest). Experimental power is particularly low when the interaction is not fully crossed (a right visual field advantage for one type of stimulus and an equally large left visual field advantage for the other type of stimulus). If such investment cannot be made, the outcome is likely to be ambiguous at best and deceiving at worst if only significant findings are published.