Mechanical Properties of Bisacryl-, Composite-, and Ceramic-resin Restorative Materials

SUMMARY Objective: Resin-based materials used in restorative dentistry are introduced at a fast pace with limited knowledge about their properties. Comparing properties of these materials from different restorative categories is lacking but can help the clinician in material selection. This study aimed to compare mechanical properties and wear resistance of bis-acryl-, composite-, and ceramic-resin restorative materials. Methods and Materials: Bisacryl-resin (Bis-R, LuxaCrown, DMG), composite-resin (Com-R, Filtek Supreme Ultra, 3M Oral Care), and ceramic-resin (Cer-R, Enamic, VITA Zahnfabrik) specimens were prepared for mechanical tests: fracture toughness (FT) with and without initial thermomechanical loading using a mastication simulator, flexural strength (FS), and flexural modulus (FM), compressive strength (CS), and volumetric wear loss measurement. The datasets for FT and wear resistance were each analyzed using two-way ANOVA followed by pairwise comparisons or Tukey testing as appropriate. The datasets for FS, FM, and CS were analyzed using one-way ANOVA followed by the Tukey test. Results: Analysis of FS, FM, and CS showed significant differences between materials, with all pairwise comparisons between materials showing significance. Analysis of FT resulted in a significant interaction between the material and treatment, with analysis of wear loss showing a significant interaction between the material and the number of cycles. Conclusions: Cer-R demonstrated superior FT, CS, and wear resistance compared to Bis-R and Comp-R materials. Fracture toughness of Bis-R increased after thermomechanical loading.

Safety and Efficacy of Drug-Coated Balloons Versus Drug-Eluting Stents in Acute Coronary Syndromes: A Prespecified Analysis of BASKET-SMALL 2

Background: Drug-coated balloons (DCBs) are an established treatment strategy for coronary artery disease. Randomized data on the application of DCBs in patients with an acute coronary syndrome (ACS) are limited. We evaluated the impact of clinical presentation (ACS versus chronic coronary syndrome) on clinical outcomes in patients undergoing DCB or drug-eluting stent (DES) treatment in a prespecified analysis of the BASKET-SMALL 2 trial (Basel Kosten Effektivitäts Trial–Drug-Coated Balloons Versus Drug-Eluting Stents in Small Vessel Interventions). Methods: BASKET-SMALL 2 randomized 758 patients with small vessel coronary artery disease to DCB or DES treatment and followed them for 3 years regarding major adverse cardiac events (cardiac death, nonfatal myocardial infarction, and target vessel revascularization). Results: Among 758 patients, 214 patients (28.2%) presented with an ACS (15 patients [7%], ST-segment–elevation myocardial infarction; 109 patients [50.9%], non–ST-segment–elevation myocardial infarction; 90 patients [42.1%], unstable angina pectoris). At 1-year follow-up, there was no significant difference in the incidence of the primary end point by randomized treatment in patients with ACS (hazard ratio, 0.50 [95% CI, 0.19–1.26] for DCB versus DES) or chronic coronary syndrome (hazard ratio, 1.29 [95% CI, 0.67–2.47] for DCB versus DES). There was no significant interaction between clinical presentation and treatment effect ( P for interaction, 0.088). For cardiac death ( P for interaction, 0.049) and nonfatal myocardial infarction ( P for interaction, 0.010), a significant interaction between clinical presentation and treatment was seen at 1 year with lower rates of these secondary end points in patients with ACS treated by DCB. At 3 years, there were similar major adverse cardiac event rates throughout groups without significant interaction between clinical presentation and treatment ( P for interaction, 0.301). All-cause mortality was higher in ACS compared with chronic coronary syndrome; however, there was no difference between DCB and DES irrespective of clinical presentation. Conclusions: In this subgroup analysis of the BASKET-SMALL 2 trial, there was no interaction between indication for percutaneous coronary intervention (acute versus chronic coronary syndrome) and treatment effect of DCB versus DES in patients with small vessel coronary artery disease. Registration: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT01574534.

Do Speed and Proximity Affect Human-Robot Collaboration with an Industrial Robot Arm?

Current guidelines for Human-Robot Collaboration (HRC) allow a person to be within the working area of an industrial robot arm whilst maintaining their physical safety. However, research into increasing automation and social robotics have shown that attributes in the robot, such as speed and proximity setting, can influence a person’s workload and trust. Despite this, studies into how an industrial robot arm’s attributes affect a person during HRC are limited and require further development. Therefore, a study was proposed to assess the impact of robot’s speed and proximity setting on a person’s workload and trust during an HRC task. Eighty-three participants from Cranfield University and the ASK Centre, BAE Systems Samlesbury, completed a task in collaboration with a UR5 industrial robot arm running at different speeds and proximity settings, workload and trust were measured after each run. Workload was found to be positively related to speed but not significantly related to proximity setting. Significant interaction was not found for trust with speed or proximity setting. This study showed that even when operating within current safety guidelines, an industrial robot can affect a person’s workload. The lack of significant interaction with trust was attributed to the robot’s relatively small size and high success rate, and therefore may have an influence in larger industrial robots. As workload and trust can have a significant impact on a person’s performance and satisfaction, it is key to understand this relationship early in the development and design of collaborative work cells to ensure safe and high productivity.

Depression and/or PTSD Comorbidity Affects Response to Antidepressants in Those With Alcohol Use Disorder

Objective: Depression and post-traumatic stress disorder (PTSD) highly co-occur with alcohol use disorder (AUD). The comparative effects of noradrenergic vs. serotonergic antidepressants on drinking and depressive outcomes for those with AUD and co-occurring depression and/or PTSD are not well known.Methods: This study was an analysis of a randomized control trial of 128 patients with AUD who had co-occurring depression and/or PTSD. They were randomized to treatment with paroxetine vs. desipramine and naltrexone vs. placebo leading to four groups: paroxetine plus naltrexone, paroxetine plus placebo, desipramine plus naltrexone, and desipramine plus placebo. Outcomes were percent of drinking days, percent heavy drinking days, drinks per drinking day (Time Line Follow-back Method), and depressive symptoms (Hamilton Depression Scale). Groups compared were (1) depression without PTSD (depression group; n = 35), (2) PTSD without depression (PTSD group; n = 33), and (3) both depression and PTSD (comorbid group; n = 60).Results: There were no overall significant differences in drinking outcomes by medication in the entire sample, and no significant interaction when diagnostic groups were not considered. However, when diagnostic groups were included in the model, the interactions between time, diagnostic group, and medication (desipramine vs. paroxetine) were significant for percent drinking days (p = 0.042), and percent heavy drinking days (p = 0.036); paroxetine showed better drinking outcomes within the depression group, whereas desipramine showed better drinking outcomes in the PTSD and comorbid groups. Regarding depressive symptoms, paroxetine was statistically superior to desipramine in the total sample (p = 0.007), but there was no significant interaction of diagnostic group and medication. Naltrexone led to a decrease in craving but no change in drinking outcomes.Conclusions: The results of this study suggest that drinking outcomes may respond differently to desipramine and paroxetine depending on comorbid MDD and/or PTSD.

Intellectual Impact of Spiritual Wellbeing, Self-Determination, and Employee Outlook on Industry 5.0

The industrial revolution and advancement in field of artificial intelligence in term of Industry 4.0 has reduced the need of human intervention at workplace. That is why murmur has started around Industry 5.0 where the focus is collaborative interaction between human and machines/robots for sustainable development of industries. The objective of this study is to assess the effects on the well-being of the employees in the dynamic setting through spirituality training. The study includes the detailed analysis of 392 responses collected from employees working in high-tech and high-automated organisations such as automobiles, FMCG, and IT with the help of structured questionnaire. This study might help improve the employee wellbeing and reduce the uncertainty in workforce participation and provide more creative, innovative, and engaging mindset in Industry 5.0. The research results have presented a significant interaction between the employee wellbeing, outlook, and self-determination at workplace in the presence of spirituality training.

Leader or Leaderess? Consequences of Using Feminatives for the Perception of Leadership

According to the Implicit Leadership Theory, leadership roles are assigned in the process of social construction and depend upon the level of congruence with the cognitive representation of a leader. Previous studies show that this cognitive representation is much more likely to involve a leader being a male rather than a female. The article presents the results of an experiment aimed at tentatively verifying whether the use of the feminine forms could increase the cognitive availability of the representation of a woman as a leader. In the experiment, 135 teams (N = 307 respondents) were randomly assigned to one of two experimental conditions: 1) generic instruction (without the use of feminatives, “Please, draw a leader”), 2) inclusive instruction (using feminatives, “Please, draw a leader/leaderess”). The results showed a significant interaction between the experimental manipulation and the proportion of women in the team. The use of feminine forms increased the percentage of females drawn as leaders only in teams with a high female-to-male ratio.

Self-Compassion Moderates the Mediating Effect of Self-Criticism in the Link Between Childhood Maltreatment and Psychopathology

Childhood maltreatment (CM) has been associated with psychological symptoms (i.e., psychopathology) among clinical and nonclinical samples. The mechanisms underlying this link have been understudied, especially among well-functioning adults. Arguably, exposure to CM may be translated into negative and critical self-appraisals and self-blame, reflected in high self-criticism. CM may also result in difficulty in extending kindness towards oneself, that is, low self-compassion. These characteristics are linked with elevated psychopathology. Nevertheless, no study has yet tested the extent to which self-criticism and self-compassion may serve as independent mechanisms linking CM and psychopathology and whether in this context self-compassion buffers the link between self-criticism and psychopathology. Here, we tested an integrative model in which the relation between CM and psychopathology was mediated by self-compassion and self-criticism, and the path between self-criticism and psychopathology was moderated by self-compassion. A convenience sample of 914 individuals completed online self-report questionnaires. Results indicated that CM was related to psychopathology through the mediation of self-compassion and self-criticism, with a significant interaction between self-criticism and self-compassion. Showing a moderated-mediational effect, the link between self-criticism and psychopathology was weaker under high than under low levels of self-compassion. Our findings highlight the importance of self-compassion, a robust resilience factor related to reduced psychopathology and moderating the link between self-criticism, a potent transdiagnostic risk factor, and psychopathology in the context of CM. These results thus provide empirical evidence for the relevance of compassion and mindfulness in counseling settings, particularly with CM survivors, who are at greater risk for psychopathology.

How Does the pH of Tree Bark Change with the Presence of the Epiphytic Bryophytes from the Family Orthotrichaceae in the Interaction with Trunk Inclination?

The pH of tree bark is affected by many factors, amongst them epiphytic bryophytes changing in their active state environment. Thus, we hypothesized that bryophytes can change bark acidity, dependently of the inclination of the branches, as inclination affect the water regime and particle deposition. We measured the pH under bryophyte cushions and compared it to nearby naked bark. Additionally, we compared results with experimental bark covering with neutral cover. We found that the pH of naked bark declines with decreasing inclination of trunks. Although bryophyte cover did not generally change the pH of the bark, there was a significant interaction with inclination: with higher inclination, bryophytes decrease the pH reaction of bark, while with lower inclination they increase it. One possible explanation may lie in changes to alkaline particle deposition, or conversely in the acidification of the bark by leaching. In addition, an experiment with a neutral cover showed that naked bark covering would substantially increase pH. As, on average, bryophytes do not change the pH of bark, there can be mutual interference between the alkalizing effect of the bark cover itself and the acidifying biological effect of bryophytes.

Impact of a Patient’s Baseline Risk on the Relative Benefit and Harm of a Preventive Treatment Strategy: Applying Trial Results in Clinical Decision Making

Background For translating an overall trial result into an individual patient’s expected absolute treatment effect, differences in relative treatment effect between patients need to be taken into account. The aim of this study was to evaluate whether relative treatment effects of medication in 2 large contemporary trials are influenced by multivariable baseline risk of an individual patient. Methods and Results In 9361 patients from SPRINT (Systolic Blood Pressure Intervention Trial), risk of major adverse cardiovascular events was assessed using a newly derived risk model. In 18 133 patients from the RE‐LY (Randomized Evaluation of Long‐Term Anticoagulant Therapy) trial, risk of stroke or systemic embolism and major bleeding was assessed using the Global Anticoagulant Registry in the Field–Atrial Fibrillation risk model. Heterogeneity of trial treatment effect was assessed using Cox models of trial allocation, model linear predictor, and their interaction. There was no significant interaction between baseline risk and relative treatment effect from intensive blood pressure lowering in SPRINT ( P =0.92) or from dabigatran compared with warfarin for stroke or systemic embolism in the RE‐LY trial ( P =0.71). There was significant interaction between baseline risk and treatment effect from dabigatran versus warfarin in the RE‐LY trial ( P <0.001) for major bleeding. Quartile‐specific hazard ratios for bleeding ranged from 0.40 (95% CI, 0.26–0.61) to 1.04 (95% CI, 0.83–1.03) for dabigatran, 110 mg, and from 0.61 (95% CI, 0.42–0.88) to 1.20 (95% CI, 0.97–1.50) for dabigatran, 150 mg, compared with warfarin. Conclusions Effect modification of relative treatment effect by individual baseline event risk should be assessed systematically in randomized clinical trials using multivariate risk prediction, not only in terms of treatment efficacy but also for important treatment harms, as a prespecified analysis. Registration URL: https://www.clinicaltrials.gov ; Unique identifier: NCT01206062.

Getting in Touch with the Lost Self: Vicarious and Affective Touch in Depersonalisation

We conducted an online study featuring two experiments in order to examine the relationship between depersonalization experiences (DP) (i.e. feelings of being detached from one’s self and body) and vicarious affective touch and self-touch. Experiment 1 examined to what extent DP traits modulate the perceived pleasantness and/or vividness of tactile experiences as imagined being received by the self and other. In experiment 2 we designed a new affective self-touch intervention in order to explore the effect of CT-optimal self-touch stroking on one’s dorsal forearm on the perceived pleasantness and vividness of tactile experiences as being received by the self and other. We found that low DP individuals reported higher perceived pleasantness and vividness rating for touch. By contrast, the high DP cohort rated all touch experiences as significantly less pleasant. No significant interaction effects for vividness ratings of touch experiences across low and high DP. In addition, our results suggest that people with low DP rate the perceived pleasantness of the imagined social touch experiences as received by the self higher than if received by the other. Interestingly, in high DP individuals, there is no difference in the perceived pleasantness of affective touch imagined as being received by the self vs the other. Finally, we found that both low and high DP participants, following our tailored CT-optimal affective self-touch intervention on one’s own body, report significantly higher ratings of vividness of tactile perception.