presynaptic currents
Recently Published Documents


TOTAL DOCUMENTS

11
(FIVE YEARS 1)

H-INDEX

9
(FIVE YEARS 0)

Author(s):  
Zijian Wang ◽  
Yanting Zhang ◽  
Haibo Shi ◽  
Lei Cao ◽  
Cairong Yan ◽  
...  


2006 ◽  
Vol 96 (2) ◽  
pp. 686-694 ◽  
Author(s):  
Toshihiko Momiyama ◽  
Laszlo Zaborszky

A whole cell patch-clamp study was carried out in slices obtained from young rat brain to elucidate the roles of somatostatin in the modulation of synaptic transmission onto cholinergic neurons in the basal forebrain (BF), a region that contains cholinergic and GABAergic corticopetal neurons and somatostatin (SS)-containing local circuit neurons. Cholinergic neurons within the BF were identified by in vivo prelabeling with Cy3 IgG. Because in many cases SS is contained in GABAergic neurons in the CNS, we investigated whether exogenously applied SS can influence GABAergic transmission onto cholinergic neurons. Bath application of somatostatin (1 μM) reduced the amplitude of the evoked GABAergic inhibitory presynaptic currents (IPSCs) in cholinergic neurons. SS also reduced the frequency of miniature IPSCs (mIPSCs) without affecting their amplitude distribution. SS-induced effect on the mIPSC frequency was significantly larger in the solution containing 7.2 mM Ca2+ than in the standard (2.4 mM Ca2+) external solution. Similar effects were observed in the case of non-NMDA glutamatergic excitatory postsynaptic currents (EPSCs). SS inhibited the amplitude of evoked EPSCs and reduced the frequency of miniature EPSCs dependent on the external Ca2+ concentration with no effect on their amplitude distribution. Pharmacological analyses using SS-receptor subtype–specific drugs suggest that SS-induced action of the IPSCs is mediated mostly by the sst2 subtype, whereas sst subtypes mediating SS-induced inhibition of EPSCs are mainly sst1 or sst4. These findings suggest that SS presynaptically inhibits both GABA and glutamate release onto BF cholinergic neurons in a Ca2+-dependent way, and that SS-induced effect on IPSCs and EPSCs are mediated by different sst subtypes.



1998 ◽  
Vol 80 (3) ◽  
pp. 1571-1576 ◽  
Author(s):  
Jeffry S. Isaacson

Isaacson, Jeffry S. GABAB receptor-mediated modulation of presynaptic currents and excitatory transmission at a fast central synapse. J. Neurophysiol. 80: 1571–1576, 1998. Large nerve terminals (calyces of Held) in the medial nucleus of the trapezoid body (MNTB) offer a unique opportunity to explore the modulation of presynaptic channels at a mammalian central synapse. In this study I examined γ-aminobutyric acid-B (GABAB)-mediated presynaptic inhibition at the calyx of Held in slices of the rat auditory brain stem. The selective GABAB agonist baclofen caused a potent inhibition of synaptic transmission and presynaptic Ca2+ current. The inhibition of presynaptic Ca2+ channels was associated with a slowing of the activation kinetics of the underlying current, and the inhibition was relieved by strong depolarization. The inhibition of both synaptic transmission and presynaptic Ca2+ current was abolished by N-ethylmaleimide, a sulfhydryl alkylating agent that uncouples the Go/Gi class of G proteins from receptors. Baclofen does not activate a potassium conductance in the presynaptic terminal. Taken together, these results suggest that GABAB receptors inhibit synaptic transmission via G protein-mediated modulation of presynaptic Ca2+ channels at this large central synapse. Furthermore, these findings demonstrate that basic mechanisms of G protein-mediated inhibition of Ca2+ channels, proposed from recordings of neuron cell bodies, are well conserved at nerve endings in the mammalian brain.



1997 ◽  
Vol 121 (8) ◽  
pp. 1531-1540 ◽  
Author(s):  
Eleonora Katz ◽  
Darío A. Protti ◽  
Pablo A. Ferro ◽  
Marcelo D. Rosato Siri ◽  
Osvaldo D. Uchitel


1995 ◽  
Vol 486 (3) ◽  
pp. 695-706 ◽  
Author(s):  
E Katz ◽  
P A Ferro ◽  
B D Cherksey ◽  
M Sugimori ◽  
R Llinás ◽  
...  


1990 ◽  
Vol 12 (4) ◽  
pp. 313-318 ◽  
Author(s):  
Herbert Wiegand ◽  
Stefan Uhlig ◽  
Ursula Gotzsch ◽  
Horst Lohmann


1984 ◽  
Vol 400 (1) ◽  
pp. 8-13 ◽  
Author(s):  
A. Mallart
Keyword(s):  


1982 ◽  
Vol 333 (1) ◽  
pp. 619-636 ◽  
Author(s):  
J. L. Brigant ◽  
A. Mallart
Keyword(s):  


Sign in / Sign up

Export Citation Format

Share Document