Aim of this paper is to estimate crystallogenic properties of gastric mucosa in connection with its microbial contamination. We investigated crystallogenic properties of some biological substrata (gastric mucosa, gastric mucosal layer homogenates) in 12 healthy individuals and 30 patients with ulcer disease complicated in 12 cases by perforation, bleeding or penetration. Biological substrata were received at fibrogastroduodenoscopy. Estimation of crystallogenic properties of biological material was accomplished by classic crystalloscopy. Biological substrata crystalloscopic investigation was accompanied by its traditional microbiological study for Helicobacter pylori and detection of other microorganisms. Our data allow to suppose dual contamination of stomach mucosa both by Helicobacter pylori and Providencia or Morganella. This combination caused elevation of gastric mucosa crystallogenic properties that provoked formation of ulcer. Procrystallogenic potential of this symbiosis may be an important link to the pathogenesis of ulcer disease which realized through microorganism-associated mucosal damage and the progression of complications.
BACTERIAL SYMBIOSIS IN COMPLICATED ULCERS: THE PATHOGENETIC HYPOTHESIS