rational refinement
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An artificial heme-enzyme with enhanced catalytic activity: evolution, functional screening and structural characterization

2015 ◽  
Vol 13 (17) ◽  
pp. 4859-4868 ◽  
Author(s):  
Rosa Vitale ◽  
Liliana Lista ◽  
Corinne Cerrone ◽  
Giorgio Caserta ◽  
Marco Chino ◽  
...  
Keyword(s):  
Catalytic Activity ◽  
Structural Characterization ◽  
Peroxidase Activity ◽  
Heme Protein ◽  
Functional Screening ◽  
Heme Enzyme ◽  
Protein Model ◽  
Rational Refinement

The rational refinement of function into the heme-protein model Mimochrome VI (MC6) resulted in a new analogue, FeIII-E2L(TD)-MC6, with an improved peroxidase activity.

Semiempirical Rate Constants for Complex Chemical Kinetics: First-Principles Assessment and Rational Refinement

2010 ◽  
Vol 123 (5) ◽  
pp. 1226-1229 ◽  
Author(s):  
Matteo Maestri ◽  
Karsten Reuter
Keyword(s):  
Chemical Kinetics ◽  
Rate Constants ◽  
First Principles ◽  
Complex Chemical ◽  
Rational Refinement

scholarly journals Life extension, human rights, and the rational refinement of repugnance

2005 ◽  
Vol 31 (11) ◽  
pp. 659-663 ◽  
Author(s):  
A D N J de Grey
Keyword(s):  
Human Rights ◽  
Life Extension ◽  
Rational Refinement
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