Prediction of Probable Alzheimer Disease in Patients With Symptoms Suggestive of Memory Impairment: Value of the Mini-Mental State Examination

2000 ◽  
Vol 9 (6) ◽  
pp. 527-532 ◽  
Author(s):  
M. C. Tierney
Keyword(s):  
Alzheimer Disease ◽  
Mental State ◽  
Memory Impairment ◽  
Mini Mental State Examination ◽  
State Examination

scholarly journals Atrial fibrillation, antithrombotic treatment, and cognitive aging

Neurology ◽  
2018 ◽  
Vol 91 (19) ◽  
pp. e1732-e1740 ◽  
Author(s):  
Mozhu Ding ◽  
Laura Fratiglioni ◽  
Kristina Johnell ◽  
Giola Santoni ◽  
Johan Fastbom ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Alzheimer Disease ◽  
Cognitive Decline ◽  
Mental State ◽  
Mini Mental State Examination ◽  
National Study ◽  
Antithrombotic Treatment ◽  
Increased Risk ◽  
Anticoagulant Drugs ◽  
State Examination

ObjectiveTo examine the association of atrial fibrillation (AF) with cognitive decline and dementia in old age, and to explore the cognitive benefit of antithrombotic treatment in patients with AF.MethodsThis population-based cohort study included 2,685 dementia-free participants from the Swedish National Study on Aging and Care in Kungsholmen, who were regularly examined from 2001–2004 to 2010–2013. AF was ascertained from clinical examination, ECG, and patient registry. Global cognitive function was assessed using the Mini-Mental State Examination. We followed the DSM-IV criteria for the diagnosis of dementia, the NINDS-AIREN (National Institute of Neurological Disorders and Stroke and Association Internationale pour la Recherché et l'Enseignement en Neurosciences) criteria for vascular dementia, and the NINCDS-ADRDA (National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association) criteria for Alzheimer disease. Data were analyzed using multiple linear mixed-effects and Cox regression models.ResultsWe identified 243 participants (9.1%) with AF at baseline. During the 9-year follow-up period, 279 participants (11.4%) developed AF and 399 (14.9%) developed dementia. As a time-varying variable, AF was significantly associated with a faster annual Mini-Mental State Examination decline (β coefficient = −0.24, 95% confidence interval [CI]: −0.31 to −0.16) and an increased hazard ratio (HR) of all-cause dementia (HR = 1.40, 95% CI: 1.11–1.77) and vascular and mixed dementia (HR = 1.88, 95% CI: 1.09–3.23), but not Alzheimer disease (HR = 1.33, 95% CI: 0.92–1.94). Among people with either prevalent or incident AF, use of anticoagulant drugs, but not antiplatelet treatment, was associated with a 60% decreased risk of dementia (HR = 0.40, 95% CI: 0.18–0.92).ConclusionAF is associated with a faster global cognitive decline and an increased risk of dementia in older people. Use of anticoagulant drugs may reduce dementia risk in patients with AF.

scholarly journals Mini-Mental State Examination and proton spectroscopy of the posterior cingulate in Alzheimer disease

2007 ◽  
Vol 1 (3) ◽  
pp. 248-252 ◽  
Author(s):  
Hae Won Lee ◽  
Paulo Caramelli ◽  
Maria Concepcion Garcia Otaduy ◽  
Ricardo Nitrini ◽  
Claudia da Costa Leite
Keyword(s):  
Alzheimer Disease ◽  
Negative Correlation ◽  
Mental State ◽  
Mini Mental State Examination ◽  
Mmse Score ◽  
Proton Spectroscopy ◽  
Positive Correlation ◽  
Posterior Cingulate ◽  
R Ratio ◽  
State Examination

Abstract To compare metabolite ratios in the posterior cingulate with the Mini-Mental State Examination (MMSE) test scores in patients with mild or moderate Alzheimer disease and in controls. Methods: We evaluated 29 patients with mild or moderate Alzheimer disease and 15 controls by proton spectroscopy with the voxel located in the posterior cingulate. The MMSE was applied to all patients and controls. The metabolic ratios: N-acetyl-aspartate/creatine (Naa/Cr), mio-inositol/creatine (mI/Cr) and mio-inositol/N-acetyl-aspartate (mI/Naa) were obtained and then post-processed using the MRUI software (magnetic resonance user interface). Results: Correlation between Naa/Cr and mI/Naa ratios in the posterior cingulate with the MMSE was observed, and a positive correlation with Naa/Cr and negative correlation with mI/Naa were seen. The mI/r ratio presented no correlation with MMSE scores. Conclusion: The positive correlation with Naa/Cr, and negative correlation with mI/Naa may corroborate that neuronal density/viability is associated to a higher MMSE score.

3D Mapping of Mini-mental State Examination Performance in Clinical and Preclinical Alzheimer Disease

2006 ◽  
Vol 20 (4) ◽  
pp. 224-231 ◽  
Author(s):  
Liana G. Apostolova ◽  
Po H. Lu ◽  
Steve Rogers ◽  
Rebecca A. Dutton ◽  
Kiralee M. Hayashi ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Mental State ◽  
Mini Mental State Examination ◽  
3D Mapping ◽  
Examination Performance ◽  
State Examination
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