Pharmacological regulation of blood glucose levels in non-insulin-dependent diabetes mellitus

1997 ◽  
Vol 157 (8) ◽  
pp. 836-848 ◽  
Author(s):  
R. Bressler
1987 ◽  
Vol 9 (5) ◽  
pp. 155-162
Author(s):  
John W. Reynolds

1. All foods should be labeled to indicate the calories, sources of the calories, the mineral and vitamin content, the types and amounts of carbohydrates, the amount of cholesterol and amounts and types of fatty acids, and the amount and type of artificial sweetener, if any. 2. A long-term evaluation of the exchange system in the dietary instruction of patients with insulin-depedent diabetes mellitus and their families should be carried out. 3. General guidelines for meal plans for youngsters with diabetes should allow for flexibility and variety in food selection so that they account for individual differences as well as being applicable to different socio-economic, cultural, and ethnic groups. 4. The distribution of calories in the diet should be: 50% to 60% carbohydrate, 15% to 20% protein, and 20% to 25% fat. 5. Nutrition education of the patient with insulin-dependent diabetes mellitus and of the patient's family about the principles of good nutrition, the importance of a balanced meal plan, and the rationale for food prohibitions should be a critical part of diabetes care. 6. Nutritional assessment should include plotting height and weight measurements on standard growth grids at regular intervals. 7. Scientifically sound cross-over studies of the differences between "simple" and "complex" carbohydrates need to be carried out on children with insulin-dependent diabetes mellitus. 8. Before optimal and safe use of fiber in therapy of children is possible, further studies are needed of the convenience and palatability of meals with currently available fiber, the use of "medicated foods" to which specific types of fiber have been added, and the extent of trace element and mineral binding by various fibers. 9. More studies are needed concerning the effects of food form, nutrient-nutrient interactions, and non-nutritive constituents of food on the glycemic effect of a given food. 10. Fructose and sorbitol may be used in limited amounts as parts of an otherwise nutritious and well-balanced meal plan, but the usefulness of their chronic ingestion has not been established. 11. Fructose and sorbitol are not substitutes for artificial noncaloric sweeteners and should not be used in the belief that they are of use in weight control. 12. Aspartame contains no calories and has no apparent risks. However, consumption of large amounts of granulated aspartame, which contains a lactose or dextrose carrier, could affect blood glucose levels. The use of cyclamate and saccharin by children with insulin-dependent diabetes mellitus should be limited pending further review. 13. The use of combinations of artificial sweeteners is reasonable to limit the risks associated with any one sweetener. 14. The medical profession and patients with insulin-dependent diabetes mellitus should be made aware that the disease is a disorder of lipid metabolism as well as carbohydrate metabolism. 15. Cholesterol and saturated fat intake should be limited and the total calories from fat should be reduced to 20% to 25% of the caloric intake. 16. Patients with insulin-dependent diabetes mellitus should have at least yearly monitoring of their fasting serum total and high-density lipoprotein cholesterol levels and the triglyceride levels. 17. The patient with insulin-dependent diabetes mellitus should be taught that, in addition to control of the dietary lipid intake, limitation of the high rate of cardiovascular complications associated with insulin-dependent diabetes mellitus depends on excellent control of blood glucose levels, age-appropriate aerobic exercise, and avoidance of the use of tobacco in any form. 18. Blood pressure should be monitored every 6 to 12 months. It is critical that hypertension be diagnosed and treated early. 19. Young patients with insulin-dependent diabetes mellitus, and their families, should be educated in a prudent approach to the use of dietary salt, with little use of added salt and a choice of foods without excessive sodium content. However, supplemental sodium chloride may be warranted when there is glycosuria in a newly diagnosed or poorly controlled patient. 20. Insulin-dependent diabetes mellitus does not result in increased dietary requirements for iron, magnesium, zinc, selenium, chromium, or other trace minerals or vitamins and, therefore, should not be an indication per se for mineral or vitamin supplements. 21. Nutritionists and dietitians with expertise in the treatment of childhood and adolescent diabetes should be recognized as valuable members of a multidisciplinary diabetes health care team. The role of such a nutritionist or dietitian includes an initial assessment and then later adjustment of meal plans to be consistent with the patient's growth, development, changes in activity level, and appearance of complications. 22. Families should be advised to follow principles of good nutrition in their own meal planning as a way to increase dietary compliance by their children with insulin-dependent diabetes mellitus. Flexibility in meal plans should be encouraged as a way to maximize dietary compliance.


1995 ◽  
Vol 23 (4) ◽  
pp. 294-298 ◽  
Author(s):  
S Okada ◽  
K Ishii ◽  
S Tanokuchi ◽  
H Hamada ◽  
K Ichiki ◽  
...  

Twenty patients with non-insulin-dependent diabetes mellitus who had been receiving appropriate dietary treatment for 3 months but whose glucose metabolism needed further improvement were treated with an α-glucosidase inhibitor. Treatment with the α-glucosidase inhibitor (0.6 mg/day) for 4 weeks, had no significant effect on blood glucose levels 2 h after breakfast or on glycosylated haemoglobin levels.


1991 ◽  
Vol 29 (4) ◽  
pp. 13-16

People with non-insulin-dependent diabetes mellitus should modify their diet, avoid obesity and take regular exercise. An oral hypoglycaemic drug may be needed if these measures fail to control blood glucose, but it is now clear that they commonly cause hypoglycaemia. More than 3 million prescriptions were issued in 1988 for the sulphonylureas (eight currently available) and the biguanide, metformin. Glibenclamide is the market leader (1.4 million prescriptions in 1988), followed by metformin (950,000), chlorpropamide (280,000), tolbutamide (260,000) and gliclazide (200,000). Instituting a district policy to restrict the choice of sulphonylureas can improve care and save money.1 No new oral hypoglycaemics have been marketed since we last reviewed them2 but their place in overall management has been clarified.


2002 ◽  
pp. 235-241 ◽  
Author(s):  
PH Riihimaa ◽  
M Knip ◽  
A Ruokonen ◽  
P Tapanainen

OBJECTIVE: To evaluate the interaction between serum free insulin, insulin-like binding protein (IGFBP)-1 and leptin concentrations during puberty in insulin-dependent diabetes mellitus (IDDM). DESIGN: Adolescent patients with IDDM (n=101, age >9 years, duration >2 years) from the Outpatient Clinic of the Department of Pediatrics at Oulu University Hospital, and non-diabetic controls, were recruited to the study. Free insulin, IGFBP-1, leptin and insulin antibody concentrations were measured from a fasting serum sample. RESULTS: Free insulin concentrations were lower in the patients than in the controls (4.3+/-2.3 mU/l compared with 6.5+/-3.1 mU/l, P<0.001), and there was an inverse correlation between free insulin and fasting blood glucose in the boys with diabetes (r=-0.53, P<0.001), whereas a positive correlation was observed between free insulin and leptin concentrations in the girls with diabetes (r=0.30, P=0.020). The IGFBP-1 concentrations were greater in the patients than in the controls (16.5+/-10.6 microg/l compared with 4.0+/-3.3, P<0.001), and they correlated significantly with blood glucose (r=0.63, P<0.001) and free insulin (r=-0.35, P<0.001). No significant difference was observed in the leptin concentrations between the patients and controls overall, despite greater total body fat in the girls with diabetes compared with the control girls. CONCLUSIONS: Adolescents with IDDM are characterised by morning hypoinsulinaemia and high circulating IGFBP-1 concentrations, which may contribute to insulin resistance and impaired metabolic control during puberty. The mechanism behind the increased total body fat in the postpubertal female patients remains to be determined.


1990 ◽  
Vol 30 (3) ◽  
pp. 281-294 ◽  
Author(s):  
E.R.B. Shanmugasundaram ◽  
G. Rajeswari ◽  
K. Baskaran ◽  
B.R.Rajesh Kumar ◽  
K.Radha Shanmugasundaram ◽  
...  

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