Clinical Significance of a Positive Antinuclear Antibody Test

JAMA ◽  
2015 ◽  
Vol 314 (8) ◽  
pp. 827 ◽  
Author(s):  
Gita Fatemi ◽  
Tanaz A. Kermani
Keyword(s):  
Clinical Significance ◽  
Antinuclear Antibody ◽  
Antibody Test ◽  
Positive Antinuclear Antibody

The Clinical Significance of the Antinuclear Antibody Test as a Screening Procedure for DNA Antibodies in SLE

1980 ◽  
Vol 25 (4) ◽  
pp. 293-298 ◽  
Author(s):  
A. E. El-Ghobarey ◽  
D. J. P. Sloane ◽  
K. Whaley
Keyword(s):  
Dna Binding ◽  
Clinical Significance ◽  
Antinuclear Antibody ◽  
Antibody Test ◽  
Diagnostic Value ◽  
Screening Procedure ◽  
Dna Antibodies ◽  
Screening Procedures

During the two-year period (1st October 1974–30th September 1976), 2979 sera were tested for DNA antibodies by the Farr test. One thousand six hundred and ninety-five of these were tested because they had high ANA titres (1/256 or greater). In this group 285 sera were found to have raised DNA binding capacities (DNA-bc), 86 of which were found in patients having diagnoses other than SLE. When the diagnoses were reviewed following the finding of a raised DNA-bc, 55 of these patients were found to be suffering from SLE. Of the 1284 sera tested for DNA antibodies without the prior ANA screening procedures, 288 were positive, 36 of which came from patients not considered to have SLE; 30 of these patients were subsequently shown to have SLE. Thus the DNA-bc test is an important tool in the diagnos is of SLE, and the ANA test appears to be a valuable screening procedure. The level of DNA-bc was not of any diagnostic value.

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