Elevated skeletal muscle creatine kinase MB isoenzyme levels in marathon runners

JAMA ◽  
1983 ◽  
Vol 250 (20) ◽  
pp. 2835-2837 ◽  
Author(s):  
A. J. Siegel
Keyword(s):  
Skeletal Muscle ◽  
Creatine Kinase ◽  
Muscle Creatine Kinase ◽  
Marathon Runners ◽  
Creatine Kinase Mb ◽  
Muscle Creatine

Skeletal muscle creatine kinase MB alterations in women marathon runners

1987 ◽  
Vol 56 (1) ◽  
pp. 49-52 ◽  
Author(s):  
Fred S. Apple ◽  
Marc A. Rogers ◽  
David C. Casal ◽  
Linda Lewis ◽  
John L. Ivy ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Creatine Kinase ◽  
Muscle Creatine Kinase ◽  
Marathon Runners ◽  
Creatine Kinase Mb ◽  
Muscle Creatine

Creatine kinase-MB isoenzyme adaptations in stressed human skeletal muscle of marathon runners

1985 ◽  
Vol 59 (1) ◽  
pp. 149-153 ◽  
Author(s):  
F. S. Apple ◽  
M. A. Rogers ◽  
D. C. Casal ◽  
W. M. Sherman ◽  
J. L. Ivy
Keyword(s):  
Skeletal Muscle ◽  
Creatine Kinase ◽  
Gastrocnemius Muscle ◽  
Acute Exercise ◽  
Elevated Serum ◽  
Long Distance ◽  
Marathon Runners ◽  
Creatine Kinase Mb ◽  
Isoenzyme Composition ◽  
Muscle Biopsies

The creatine kinase (CK) isoenzyme composition was determined in serial gastrocnemius muscle biopsies obtained from 12 male marathon runners. The mean muscle CK-MB composition significantly increased after chronic exercise (training) from 5.3% (pretraining) to 7.7% (premarathon) as well as after acute exercise (postmarathon) to 10.5% of the total CK activity (P less than 0.05). However, no significant differences in total CK activities were detected. Additionally, mitochondrial CK and CK-BB isoenzymes were present in muscle homogenates. A significant correlation was observed in the increase in mean serum total CK (3,322 U/l) and CK-MB (174 U/l) activities 24 h after the race (r = 0.98, P less than 0.05). These results show that gastrocnemius muscle adapts to long-distance training and racing with increased CK-MB activities and imply that skeletal muscle is the major source of elevated serum CK-MB activities in marathon runners.

Creatine kinase isoenzymes of mitochondrial origin in human serum.

1979 ◽  
Vol 25 (6) ◽  
pp. 943-947 ◽  
Author(s):  
G P James ◽  
R L Harrison
Keyword(s):  
Skeletal Muscle ◽  
Creatine Kinase ◽  
Lactate Dehydrogenase ◽  
Serum Samples ◽  
Muscle Creatine Kinase ◽  
Cellulose Acetate Electrophoresis ◽  
University Of Texas ◽  
Creatine Kinase Isoenzymes ◽  
Mitochondrial Origin ◽  
Muscle Creatine

Abstract We measured creatine kinase (EC 2.7.3.2) activity in 1009 serum samples from 538 patients in the intensive-care units of the University of Texas Medical Branch hospitals. Creatine kinase isoenzymes migrating cathodal to skeletal muscle creatine kinase (CK-MM) on cellulose acetate electrophoresis were found in sera from 14 of the 538 patients. Creatine kinase, lactate dehydrogenase (EC 1.1.1.27), aspartate aminotransferase (EC 2.6.1.1), and alanine aminotransferase (EC 2.6.1.2) activities were abnormally increased in these 14 patients. Liver lactate dehydrogenase isoenzyme (LDH5) and cardiac creatine kinase isoenzyme (CK-MB) were abnormally increased in 12 and eight of these patients, respectively. Ten of the 14 patients died during their hospital admission. We believe the creatine kinase isoenzymes that migrated cathodal to skeletal muscle creatine kinase (CK-MM) were of mitochondrial origin.

Genotypes Of The Skeletal Muscle Creatine Kinase Gene And Exertional Rhabdomyolyis

2009 ◽  
Vol 41 ◽  
pp. 164
Author(s):  
Yuval Heled ◽  
Patricia A. Deuster ◽  
Sheila Muldoon ◽  
Carmen Sesvold-Contreras ◽  
Kimbra Kenny ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Creatine Kinase ◽  
Muscle Creatine Kinase ◽  
Kinase Gene ◽  
Muscle Creatine
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