The Significance of Cortical Extracellular H+, K+and Ca2+Activities for Regulation of Local Cerebral Blood Flow under Conditions of Enhanced Neuronal Activity

Author(s):  
Dieter Heuser
1980 ◽  
Vol 190 (1) ◽  
pp. 51-65 ◽  
Author(s):  
Takashi Tsubokawa ◽  
Yoichi Katayama ◽  
Tsutomu Kondo ◽  
Yuichi Ueno ◽  
Nariyuki Hayashi ◽  
...  

2021 ◽  
Author(s):  
Patrick S Hosford ◽  
Jack A Wells ◽  
Iván Ruminot ◽  
Isabel N Christie ◽  
Shefeeq M Theparambil ◽  
...  

SummaryThe mechanisms of neurovascular coupling remain incompletely understood. Here we show in experimental animal models that the neuronal activity-dependent increases in local cerebral blood flow in the somatosensory cortex are abolished by saturation of brain CO2-sensitive vasodilatory mechanism or disruption of brain HCO3-/CO2 transport, independently of baseline cerebral perfusion and brain tissue pH. These results suggest that increases in metabolic CO2 production and CO2 signalling play an important role in the development of neurovascular coupling response.


2018 ◽  
Vol 08 (03) ◽  
Author(s):  
Yasuyuki Matsuura ◽  
Toru Tanimura ◽  
Daisuke Iida ◽  
Hiroki Takada

1988 ◽  
Vol 10 (3) ◽  
pp. 151-155 ◽  
Author(s):  
Bruce I. Tranmer ◽  
Cordell E. Gross ◽  
Geoff R. Adey ◽  
Ted S. Keller ◽  
Ken Nagata ◽  
...  

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