scholarly journals Changes of Local Cerebral Blood Flow Accompanied by Increased Neuronal Activity in the Thalamic Relay Nucleus and Somatosensory Cortex Induced by Sensory Stimulation

1980 ◽  
Vol 20 (10) ◽  
pp. 1007-1014 ◽  
Author(s):  
TAKASHI TSUBOKAWA ◽  
YOICHI KATAYAMA ◽  
TSUTOMU KONDO ◽  
YUICHI UENO ◽  
NARIYUKI HAYASHI ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Somatosensory Cortex ◽  
Neuronal Activity ◽  
Sensory Stimulation ◽  
Local Cerebral Blood Flow ◽  
Thalamic Relay ◽  
Relay Nucleus

Changes in local cerebral blood flow and neuronal activity during sensory stimulation in normal and sympathectomized cats

1980 ◽  
Vol 190 (1) ◽  
pp. 51-65 ◽  
Author(s):  
Takashi Tsubokawa ◽  
Yoichi Katayama ◽  
Tsutomu Kondo ◽  
Yuichi Ueno ◽  
Nariyuki Hayashi ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Neuronal Activity ◽  
Sensory Stimulation ◽  
Local Cerebral Blood Flow

scholarly journals CO2 signalling mediates neurovascular coupling in the cerebral cortex

2021 ◽  
Author(s):  
Patrick S Hosford ◽  
Jack A Wells ◽  
Iván Ruminot ◽  
Isabel N Christie ◽  
Shefeeq M Theparambil ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Cortex ◽  
Cerebral Blood Flow ◽  
Animal Models ◽  
Neuronal Activity ◽  
Cerebral Perfusion ◽  
Neurovascular Coupling ◽  
Local Cerebral Blood Flow ◽  
Experimental Animal Models ◽  
Activity Dependent

SummaryThe mechanisms of neurovascular coupling remain incompletely understood. Here we show in experimental animal models that the neuronal activity-dependent increases in local cerebral blood flow in the somatosensory cortex are abolished by saturation of brain CO2-sensitive vasodilatory mechanism or disruption of brain HCO3-/CO2 transport, independently of baseline cerebral perfusion and brain tissue pH. These results suggest that increases in metabolic CO2 production and CO2 signalling play an important role in the development of neurovascular coupling response.

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