scholarly journals Cost-effectiveness of biologic response modifiers compared to disease-modifying antirheumatic drugs for rheumatoid arthritis: A systematic review

2010 ◽  
Vol 63 (1) ◽  
pp. 65-78 ◽  
Author(s):  
Gabrielle van der Velde ◽  
Ba' Pham ◽  
Márcio Machado ◽  
Luciano Ieraci ◽  
William Witteman ◽  
...  
2011 ◽  
Vol 13 (5) ◽  
pp. 381-382
Author(s):  
Aarat M. Patel ◽  
Daniel Lupash ◽  
Douglas Chew ◽  
Marc C. Levesque ◽  
Larry W. Moreland

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Maurizio Benucci ◽  
Gianantonio Saviola ◽  
Mariangela Manfredi ◽  
Piercarlo Sarzi-Puttini ◽  
Fabiola Atzeni

The cost effectiveness of treatments that have changed the “natural history” of a chronic progressive disease needs to be evaluated over the long term. Disease-modifying antirheumatic drugs (DMARDs) are the standard treatment of rheumatoid arthritis (RA) and should be started as early as possible. A number of studies have shown that they are effective in improving disease activity and function, and in joint damage. Our review was focused on revision and critical evaluation of the studies including the literature on cost effectiveness of DMARDs (cyclosporine A, sulphasalazine, leflunomide, and methotrexate). The European League Against Rheumatism (EULAR) recommendations showed that traditional DMARDs are cost effective at the time of disease onset. They are less expensive than biological DMARDs and can be useful in controlling disease activity in early RA.


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