scholarly journals Linking Physical Function Outcomes in Rheumatology: Performance of a Crosswalk for Converting Health Assessment Questionnaire Scores to Short Form 36 Physical Functioning Scale Scores

2014 ◽  
Vol 66 (11) ◽  
pp. 1754-1758 ◽  
Author(s):  
Martijn A. H. Oude Voshaar ◽  
Peter M. ten Klooster ◽  
Erik Taal ◽  
Frederick Wolfe ◽  
Harald Vonkeman ◽  
...  
Keyword(s):  
Physical Function ◽  
Physical Functioning ◽  
Health Assessment Questionnaire ◽  
Short Form ◽  
Health Assessment ◽  
Short Form 36 ◽  
Physical Functioning Scale ◽  
Scale Scores ◽  
Assessment Questionnaire

Characterization of patients with chronic refractory gout who do and do not have clinically apparent tophi and their response to pegloticase

Rheumatology ◽  
2019 ◽  
Vol 58 (8) ◽  
pp. 1422-1431 ◽  
Author(s):  
N Lawrence Edwards ◽  
Jasvinder A Singh ◽  
Orrin Troum ◽  
Anthony E Yeo ◽  
Peter E Lipsky
Keyword(s):  
Health Assessment Questionnaire ◽  
Global Assessment ◽  
Short Form ◽  
Bodily Pain ◽  
Health Assessment ◽  
Serum Urate ◽  
Patient Global Assessment ◽  
Short Form 36 ◽  
Assessment Questionnaire ◽  
Questionnaire Disability

Abstract Objective To determine the characteristics and response to pegloticase of patients with chronic refractory gout with and without clinically apparent tophi. Methods Results from two randomized controlled trials of pegloticase in patients with chronic refractory gout with clinically apparent tophi or without tophi were used to assess baseline and on-treatment between-group differences. Results Patients with tophi were significantly older than those without tophi, had a significantly longer duration of disease, higher numbers of tender and swollen joints, higher Patient Global Assessment scores and Health Assessment Questionnaire-Disability Index scores, and lower Arthritis-Specific Health Index scores. Patients with tophaceous gout also had significantly lower scores for physical functioning, role physical, social functioning, and the physical component summary scores of the Short Form 36 vs patients without tophi. In addition, subjects with clinically apparent tophi had a significantly lower mean estimated glomerular filtration rate. Pegloticase treatment of tophaceous patients caused significant reductions in serum urate, flares, Patient Global Assessment, tender joints, swollen joints, Health Assessment Questionnaire-Disability Index, visual analogue scale pain and Short Form 36 Bodily Pain, whereas patients without tophi had significant improvement in serum urate, flares, Patient Global Assessment, tender joints, and Short Form 36 Bodily Pain, but not swollen joints, Health Assessment Questionnaire-Disability Index functional score or pain visual analogue scale. Treatment with pegloticase had no effect on estimated glomerular filtration rate despite significant lowering of the urinary uric acid: creatinine ratio. Conclusion Patients with chronic refractory gout and clinically apparent tophi have more severe disease as well as reduced renal function. Both groups experienced significant clinical benefit with pegloticase treatment, although no change in renal function was noted.

scholarly journals Qualidade de vida e capacidade funcional em pacientes com úlcera arterial

2016 ◽  
Vol 34 (2) ◽  
Author(s):  
Márcia Maria Renó Moreira ◽  
Fabiana Da Silva Augusto ◽  
Leila Blanes ◽  
Alfredo Gragnani ◽  
Lydia Masako Ferreira
Keyword(s):  
Health Survey ◽  
Health Assessment Questionnaire ◽  
Short Form ◽  
Health Assessment ◽  
Minas Gerais ◽  
Short Form 36 ◽  
Sf 36 ◽  
Assessment Questionnaire

Objetivo: Avaliar a Qualidade de Vida (qv) e a capacidade funcional em pacientes com Doença Arterial Periférica (dap) e Úlceras Arteriais (ua).Metodologia: Estudo clínico descritivo e transversal, realizado no Sul de Minas Gerais, Brasil. Sessenta pacientes adultos alocados em três grupos —grupo dap com ua, grupo dap sem ua e grupo controle, sem dap e sem ua— foram entrevistados,utilizando-se os questionários Health Assessment Questionnaire (haq) e o Short Form-36 Health Survey (sf-36) para medir a capacidade funcional e a qv, respectivamente. Para a comparação entre os grupos, foi utilizado o teste de Kruskal-Wallis.Resultados: Quarenta e dois participantes (70%) são mulheres e a idade média foi de 63 anos. Os pacientes com dap, com ou sem ua, apresentaram incapacidade funcional significativamente maior que pacientes sem dap (p < 0,01) nos componentes relacionados a deambulação, uso de utensílios domésticos, higiene e apreensão/sustentação de objetos. Os pacientes com dap, com ou sem lesões, apresentaram sf-36 escores significativamente mais baixos —menor qv— nos domínios Capacidade funcional, Aspectos físicos, Dorcorporal, Vitalidade, Aspectos sociais e Aspecto emocional do sf-36 em relação ao grupo controle (p < 0,001). Também foram observadas diferenças significativas (p < 0,001) entre o grupo controle e o grupo com dap e ua nos domínios Estado geral desaúde e Saúde mental.Conclusão: Os pacientes com dap, com ou sem úlcera, apresentaram redução na capacidade de realização de algumas atividades cotidianas, além de baixos níveis de qv quandocomparados aos pacientes sem a doença.

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