A Topological Stitching Strategy for Biocompatible Wet Adhesion Using Mussel‐Inspired Polyurethane

Achieving strong adhesion of bioadhesives on wet tissues remains a challenge and an acute clinical demand because of the interfering interfacial water and limited adhesive-tissue interactions. Here we report a self-gelling and adhesive polyethyleneimine and polyacrylic acid (PEI/PAA) powder, which can absorb interfacial water to form a physically cross-linked hydrogel in situ within 2 seconds due to strong physical interactions between the polymers. Furthermore, the physically cross-linked polymers can diffuse into the substrate polymeric network to enhance wet adhesion. Superficial deposition of PEI/PAA powder can effectively seal damaged porcine stomach and intestine despite excessive mechanical challenges and tissue surface irregularities. We further demonstrate PEI/PAA powder as an effective sealant to enhance the treatment outcomes of gastric perforation in a rat model. The strong wet adhesion, excellent cytocompatibility, adaptability to fit complex sites, and easy synthesis of PEI/PAA powder make it a promising bioadhesive for numerous biomedical applications.

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Mechanics of wet adhesion in soft interaction with patterned morphology

Bioinspiration & Biomimetics ◽

10.1088/1748-3190/aaeb09 ◽

2018 ◽

Vol 14 (1) ◽

pp. 016005 ◽

Cited By ~ 2

Author(s):

Pho Van Nguyen ◽

Van Anh Ho

Keyword(s):

Wet Adhesion ◽

Soft Interaction

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Wet adhesion of epoxy–amine coatings on 2024-T3 aluminum alloy

Materials Chemistry and Physics ◽

10.1016/j.matchemphys.2014.02.022 ◽

2014 ◽

Vol 145 (3) ◽

pp. 342-349 ◽

Cited By ~ 16

Author(s):

T.H. Wu ◽

A. Foyet ◽

A. Kodentsov ◽

L.G.J. van der Ven ◽

R.A.T.M. van Benthem ◽

...

Keyword(s):

Aluminum Alloy ◽

Wet Adhesion ◽

Epoxy Amine

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Corrosion of Painted Metals—A Review

CORROSION ◽

10.5006/1.3581899 ◽

1982 ◽

Vol 38 (7) ◽

pp. 374-383 ◽

Cited By ~ 98

Author(s):

Henry Leidheiser

Keyword(s):

Interfacial Region ◽

Wet Adhesion ◽

Filiform Corrosion ◽

Cathodic Delamination

Abstract Seven types of corrosion and precorrosion of painted metals are reviewed: blistering, early rusting, flash rusting, anodic undermining, filiform corrosion, cathodic delamination, and wet adhesion. The importance of the nature of the interfacial region between the coating and the metal is emphasized. Ten unsolved problems are described.

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Relation between Wet Adhesion of Coated Steel and Stress Changes in Coating Film

Tetsu-to-Hagane ◽

10.2355/tetsutohagane1955.71.11_1550 ◽

1985 ◽

Vol 71 (11) ◽

pp. 1550-1559

Author(s):

Minoru KITAYAMA ◽

Hisao ODASHIMA ◽

Takaho SAITO ◽

Yoshihiko HIRANO ◽

Teruo YOSHIDA

Keyword(s):

Coating Film ◽

Coated Steel ◽

Wet Adhesion ◽

Stress Changes

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Extreme wet adhesion of a novel epoxy-amine coating on aluminum alloy 2024-T3

Progress in Organic Coatings ◽

10.1016/j.porgcoat.2013.09.001 ◽

2014 ◽

Vol 77 (1) ◽

pp. 176-183 ◽

Cited By ~ 28

Author(s):

N.N.A.H. Meis ◽

L.G.J. van der Ven ◽

R.A.T.M. van Benthem ◽

G. de With

Keyword(s):

Aluminum Alloy ◽

Wet Adhesion ◽

Epoxy Amine ◽

Aluminum Alloy 2024

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A wet adhesion strategy via synergistic cation–π and hydrogen bonding interactions of antifouling zwitterions and mussel-inspired binding moieties

Journal of Materials Chemistry A ◽

10.1039/c9ta08152f ◽

2019 ◽

Vol 7 (38) ◽

pp. 21944-21952 ◽

Cited By ~ 8

Author(s):

Lei Xie ◽

Lu Gong ◽

Jiawen Zhang ◽

Linbo Han ◽

Li Xiang ◽

...

Keyword(s):

Hydrogen Bonding ◽

Binding Mechanism ◽

Wet Adhesion ◽

Hydrogen Bonding Interactions ◽

Adhesive Materials

An orientation-mediated zwitterion–Dopa binding mechanism is established as a promising wet adhesion strategy to design zwitterion–Dopa-mediated adhesive materials.

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