A Novel Propargylation/Cycloisomerization Tandem Process Catalyzed by a Ruthenium(II)/Trifluoroacetic Acid System: One-Pot Entry to Fully Substituted Furans from Readily Available Secondary Propargylic Alcohols and 1,3-Dicarbonyl Compounds

2007 ◽  
Vol 349 (3) ◽  
pp. 382-394 ◽  
Author(s):  
Victorio Cadierno ◽  
José Gimeno ◽  
Noel Nebra
Keyword(s):  
Trifluoroacetic Acid ◽  
Acid System ◽  
One Pot ◽  
Dicarbonyl Compounds ◽  
Propargylic Alcohols ◽  
Tandem Process ◽  
Substituted Furans

scholarly journals Trifluoroacetic Acid as an Effective Catalyst for Biginelli Reaction: One-Pot, Three-Component Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones (and-Thiones)

2011 ◽  
Vol 8 (s1) ◽  
pp. S266-S270 ◽  
Author(s):  
Mohammad R. Mohammadizadeh ◽  
Neda Firoozi
Keyword(s):  
Trifluoroacetic Acid ◽  
Biginelli Reaction ◽  
One Pot ◽  
Dicarbonyl Compounds ◽  
Effective Catalyst

Trifluoroacetic acid (TFA) is introduced as an effective catalyst for promotion of Biginelli reaction. 3,4-Dihydropyrimidin-2(1H)-one (-thione) derivatives (DHPMs) were simply and efficiently prepared using TFA catalyzed one-pot, three-component condensationβ-dicarbonyl compounds, aldehydes and urea (thio).

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