Enantioselective Synthesis of Chromanones through Organocatalytic Tandem Reactions

2020 ◽  
Vol 362 (23) ◽  
pp. 5524-5528
Author(s):  
Mengxue Lu ◽  
Xin Wang ◽  
Zongli Xiong ◽  
Jingxiang Duan ◽  
Wen Ren ◽  
...  
Keyword(s):  
Enantioselective Synthesis ◽  
Tandem Reactions

Catalytic enantioselective synthesis of indolizino[8,7-b]indole alkaloid derivatives based on the tandem reaction of tertiary enamides

2021 ◽  
Author(s):  
Xin-Ming Xu ◽  
Ming Xie ◽  
Jiazhu Li ◽  
Mei-Xiang Wang
Keyword(s):  
Indole Alkaloid ◽  
Enantioselective Synthesis ◽  
High Yield ◽  
Tandem Reaction ◽  
Indole Derivatives

An exquisite Pybox/Cu(OTf)2-catalyzed asymmetric tandem reaction of tertiary enamides was developed, which enabled the expeditious synthesis of indolizino[8,7-b]indole derivatives in high yield, excellent enantioselectivity and diastereoselectivity.

Enabling Selective Tandem Reactions via Catalyst Architecture Engineering

2020 ◽  
Vol 2 (10) ◽  
pp. 929-941
Author(s):  
Hong Je Cho ◽  
Bingjun Xu
Keyword(s):  
Tandem Reactions

Enantioselective Synthesis of Azamerone

2018 ◽  
Author(s):  
Matthew L. Landry ◽  
Grace McKenna ◽  
Noah Burns
Keyword(s):  
Late Stage ◽  
Cross Coupling ◽  
Enantioselective Synthesis ◽  
Selective Synthesis

A concise and selective synthesis of the dichlorinated meroterpenoid azamerone is described. The paucity of tactics for the synthesis of chiral organochlorides motivated the development of unique strategies for accessing these motifs in enantioenriched forms. The route features a novel enantioselective chloroetherification reaction, a Pd-catalyzed cross-coupling between a quinone diazide and a boronic hemiester, and a late-stage tetrazine [4+2]-cycloaddition/oxidation cascade.

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