scholarly journals Large scale, voxel‐to‐voxel correlation analysis of tau positron emission tomography signal to histological pathology in non‐Alzheimer tauopathies

2020 ◽  
Vol 16 (S5) ◽  
Author(s):  
Yuheng Chen ◽  
Maryana Alegro ◽  
Dulce Ovando Morales ◽  
Renaud Joie ◽  
Anubhav Shankar ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Correlation Analysis ◽  
Large Scale ◽  
Emission Tomography ◽  
Positron Emission

scholarly journals Microfluidics for Synthesis of Peptide-Based PET Tracers

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Yang Liu ◽  
Mei Tian ◽  
Hong Zhang
Keyword(s):  
Organic Chemistry ◽  
Positron Emission Tomography ◽  
Large Scale ◽  
Lab On A Chip ◽  
Emission Tomography ◽  
Receptor Imaging ◽  
Pet Tracers ◽  
Radiolabeled Peptides ◽  
High Affinity ◽  
Positron Emission

Positron emission tomography (PET) is a powerful noninvasive tool for acquisition of the physiological parameters in human and animals with the help of PET tracers. Among all the PET tracers, radiolabeled peptides have been widely explored for cancer-related receptor imaging due to their high affinity and specificity to receptors. But radiochemistry procedures for production of peptide-based PET tracers are usually complex, which makes large-scale clinical studies relatively challenging. New radiolabeling technologies which could simplify synthesis and purification procedures, are extremely needed. Over the last decade, microfluidics and lab-on-a-chip (LOC) technology have boomed as powerful tools in the field of organic chemistry, which potentially provide significant help to the PET chemistry. In this minireview, microfluidic radiolabeling technology is described and its application for synthesis of peptide-based PET tracers is summarized and discussed.

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