Immunoglobulin G Subclasses of Antinuclear Antibodies and Renal Deposits. Comparison of Systemic Lupus Erythematosus, Drug-Induced Lupus and Rheumatoid Arthritis

1971 ◽  
Vol 14 (2) ◽  
pp. 276-282 ◽  
Author(s):  
Jovan N. Kacaki ◽  
Mary Lou Callerame ◽  
Stephen E. Blomgren ◽  
John H. Vaughan
Keyword(s):  
Rheumatoid Arthritis ◽  
Systemic Lupus Erythematosus ◽  
Immunoglobulin G ◽  
Lupus Erythematosus ◽  
Antinuclear Antibodies ◽  
Systemic Lupus ◽  
Drug Induced ◽  
Immunoglobulin G Subclasses

Combination therapy for rheumatoid arthritis and drug-induced systemic lupus erythematosus

1994 ◽  
Vol 13 (3) ◽  
pp. 522-524 ◽  
Author(s):  
A. A. Borg ◽  
M. J. Davis ◽  
P. T. Dawes ◽  
M. F. Shadforth
Keyword(s):  
Rheumatoid Arthritis ◽  
Systemic Lupus Erythematosus ◽  
Combination Therapy ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Drug Induced

TREATMENT OF SYSTEMIC LUPUS ERYTHEMATOSUS COMPLICATED BY NEPHRITIS IN CHILDREN

PEDIATRICS ◽  
1967 ◽  
Vol 40 (5) ◽  
pp. 822-827
Author(s):  
Wolfgang W. Hagge ◽  
Edmund C. Burke ◽  
Gunnar B. Stickler
Keyword(s):  
Rheumatoid Arthritis ◽  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Clinical Course ◽  
Discoid Lupus Erythematosus ◽  
High Dose ◽  
Low Doses ◽  
Systemic Lupus ◽  
Drug Induced ◽  
High Doses

The clinical course of 41 patients who had systemic lupus erythematosus complicated by nephritis with symptoms beginning before they were 15 years old was reviewed. The retrospective analysis showed a definite trend toward prolonged survival among the patients receiving high doses of steroids, compared to those receiving no or low doses. We conclude that it is no longer justified to withhold high-dose steroid therapy from children with lupus nephritis, but it should be emphasized equally that this does not apply to children with discoid lupus erythematosus, rheumatoid arthritis with a positive LE clot test, or drug-induced lupus erythematosus. Our present plan of management is outlined.

Systemic Lupus Erythematosus

PEDIATRICS ◽  
1969 ◽  
Vol 43 (3) ◽  
pp. 472-473
Author(s):  
G. B. Stickler ◽  
E. C. Burke
Keyword(s):  
Rheumatoid Arthritis ◽  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Clinical Picture ◽  
Renal Involvement ◽  
Systemic Lupus ◽  
Drug Induced

The article, "Systemic Lupus Erythematosus in Childhood," by Drs. Meislin and Rothfield raises a number of questions because our group recently published our experience with this disease. The authors failed to define precisely what they mean by "systemic lupus erythematosus." We note that 10% of their patients had a negative LE clot test, and apparently patients with drug-induced lupus erythematosus were included. Furthermore, it is not possible to ascertain whether or not their group includes children with the clinical picture of degenerative rheumatoid arthritis with a positive LE clot test and absence of renal involvement.

Organized Intraglomerular Deposits in NZB Mouse Disease

1971 ◽  
Vol 29 ◽  
pp. 544-545
Author(s):  
Francis R. Comerford ◽  
Alan S. Cohen
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Antinuclear Antibodies ◽  
Human Systemic Lupus Erythematosus ◽  
Systemic Lupus ◽  
Glomerular Lesion ◽  
Ultrastructural Studies ◽  
Dense Deposits ◽  
Experimental Nephritis ◽  
Glomerular Lesions

Mice of the inbred NZB strain develop a spontaneous disease characterized by autoimmune hemolytic anemia, positive lupus erythematosus cell tests and antinuclear antibodies and nephritis. This disease is analogous to human systemic lupus erythematosus. In ultrastructural studies of the glomerular lesion in NZB mice, intraglomerular dense deposits in mesangial, subepithelial and subendothelial locations were described. In common with the findings in many examples of human and experimental nephritis, including many cases of human lupus nephritis, these deposits were amorphous or slightly granular in appearance with no definable substructure.We have recently observed structured deposits in the glomeruli of NZB mice. They were uncommon and were found in older animals with severe glomerular lesions by morphologic criteria. They were seen most commonly as extracellular elements in subendothelial and mesangial regions. The deposits ranged up to 3 microns in greatest dimension and were often adjacent to deposits of lipid-like round particles of 30 to 250 millimicrons in diameter and with amorphous dense deposits.

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