Treatment of acquired factor VIII inhibitor using intravenous immunoglobulin in two patients with systemic lupus erythematosus

1997 ◽  
Vol 40 (4) ◽  
pp. 775-778 ◽  
Author(s):  
Thomas E. Lafferty ◽  
J. Bruce Smith ◽  
Stephen J. Schuster ◽  
Raphael J. Dehoratius
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Factor Viii ◽  
Intravenous Immunoglobulin ◽  
Lupus Erythematosus ◽  
Factor Viii Inhibitor ◽  
Systemic Lupus ◽  
Viii Inhibitor ◽  
Acquired Factor Viii Inhibitor

Cyclosporine Therapy for Acquired Factor VIII Inhibitor in a Patient with Systemic Lupus Erythematosus

1996 ◽  
Vol 76 (03) ◽  
pp. 344-346 ◽  
Author(s):  
S Schulman ◽  
P Langevitz ◽  
A Livneh ◽  
U Martinowitz ◽  
U Seligsohn ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Factor Viii ◽  
Lupus Erythematosus ◽  
Autoimmune Disorder ◽  
Serum Levels ◽  
High Dose ◽  
Factor Viii Inhibitor ◽  
Systemic Lupus ◽  
Acquired Factor Viii Inhibitor ◽  
One Year

SummaryThe case of a 27-year-old woman with systemic lupus erythematosus and development of an autoantibody against factor VIII during an exacerbation of her underlying disorder is described. Attempts to eliminate the antibody with high dose gammaglobulin and repeated courses of cyclophosphamide failed, whereafter she received cyclosporine in increasing doses. When therapeutic serum levels of cyclosporine were achieved (150-350 ng/ml) the inhibitor rapidly decreased and disappeared with a concomitant normalization of the factor VIII levels. Treatment with cyclosporine was subsequently reduced and discontinued after one year, and at present no inhibitor is detectable. In view of the successful results with cyclosporine treatment in 4 of 6 previous cases and in all 3 previous cases with autoimmune disorders, this regimen should be evaluated in a systematic manner as a potential first line drug in patients with acquired hemophilia and an underlying autoimmune disorder.

Low response to high‐dose intravenous immunoglobulin in the treatment of acquired factor VIII inhibitor

1996 ◽  
Vol 95 (4) ◽  
pp. 750-753 ◽  
Author(s):  
Laurent Crenier ◽  
Jean Ducobu ◽  
Jean‐Marin Des Grottes ◽  
Jean Cerny ◽  
Christian Delaunoit ◽  
...  
Keyword(s):  
Factor Viii ◽  
Intravenous Immunoglobulin ◽  
High Dose ◽  
Factor Viii Inhibitor ◽  
Viii Inhibitor ◽  
Acquired Factor Viii Inhibitor
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