The many worlds of reducing interleukin-1

2005 ◽  
Vol 52 (7) ◽  
pp. 1960-1967 ◽  
Author(s):  
Charles A. Dinarello
Keyword(s):  
2015 ◽  
pp. 1-8
Author(s):  
Olga Maiorova ◽  
Deborah Martinsen
Keyword(s):  

Wilmott ◽  
2020 ◽  
Vol 2020 (105) ◽  
pp. 10-11
Author(s):  
Aaron Brown

Leonardo ◽  
1983 ◽  
Vol 16 (3) ◽  
pp. 256
Author(s):  
Michael Fitzgerald ◽  
Karlen Mooradian
Keyword(s):  

1993 ◽  
Vol 178 (3) ◽  
pp. 1085-1090 ◽  
Author(s):  
M I Block ◽  
M Berg ◽  
M J McNamara ◽  
J A Norton ◽  
D L Fraker ◽  
...  

D factor, also known as leukemia inhibitory factor, is a pleiotropic cytokine whose role during acute injury and inflammation is not known. Intraperitoneal administration of Escherichia coli endotoxin induced D factor gene expression in mice, and passive immunization against D factor protected them from the lethal effects of endotoxin and blocked endotoxin-induced increases in serum levels of interleukin 1 and 6. Peak levels of tumor necrosis factor and interferon gamma were not affected. These results indicate that D factor is an essential early mediator of the inflammatory cytokine response and therefore may be important in the pathogenesis of the many inflammatory conditions, such as sepsis, arthritis, allograft rejection, and cancer immunotherapy.


Author(s):  
Duncan Weaver

Space has always animated world politics, but three spatial orientations are striking. First, the Westphalian orientation deems space a sovereign power container. Second, the scalar takes recourse to the local, regional, national, and global spaces in which world politics is played out. Third, the relational deems space a (re)produced, sociohistorically contingent phenomenon that changes according to the humans occupying it and the thought, power, and resources flowing through it. Under this latter orientation, space is lived, lived in and lived through. Whilst relationality, to a degree, calls into question the received wisdoms of International Relations (IR), the fixity of sovereignty and territory remain. The orientations coexist concomitantly, reflecting the “many worlds” humankind occupies.


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