Are there differences in the catalytic activity per unit enzyme of recombinantly expressed and human liver microsomal cytochrome P450 2C9? A systematic investigation into inter-system extrapolation factors

In-vitro metabolism of celecoxib, a cyclooxygenase-2 inhibitor, by allelic variant forms of human liver microsomal cytochrome P450 2C9: correlation with CYP2C9 genotype and in-vivo pharmacokinetics

Pharmacogenetics ◽

10.1097/00008571-200104000-00006 ◽

2001 ◽

Vol 11 (3) ◽

pp. 223-235 ◽

Cited By ~ 84

Author(s):

Cuyue Tang ◽

Magang Shou ◽

Thomas H. Rushmore ◽

Qin Mei ◽

Punam Sandhu ◽

...

Keyword(s):

Cytochrome P450 ◽

Human Liver ◽

In Vitro Metabolism ◽

Cytochrome P450 2C9 ◽

Microsomal Cytochrome ◽

Cyp2c9 Genotype ◽

In Vivo Pharmacokinetics

Suitable albumin concentrations for enhanced drug oxidation activities mediated by human liver microsomal cytochrome P450 2C9 and other forms predicted with unbound fractions and partition/distribution coefficients of model substrates

Xenobiotica ◽

10.1080/00498254.2018.1482576 ◽

2018 ◽

Vol 49 (5) ◽

pp. 557-562 ◽

Cited By ~ 5

Author(s):

Kanami Shimura ◽

Norie Murayama ◽

Saki Tanaka ◽

Shunsuke Onozeki ◽

Hiroshi Yamazaki

Keyword(s):

Cytochrome P450 ◽

Human Liver ◽

Distribution Coefficients ◽

Cytochrome P450 2C9 ◽

Microsomal Cytochrome ◽

Drug Oxidation

Effect of Silybin and its congeners on human liver microsomal cytochrome P450 activities

Phytotherapy Research ◽

10.1002/ptr.1000 ◽

2002 ◽

Vol 16 (7) ◽

pp. 632-638 ◽

Cited By ~ 94

Author(s):

Roman Zuber ◽

Martin Modrianský ◽

Zdeněk Dvořák ◽

Petr Rohovský ◽

Jitka Ulrichová ◽

...

Keyword(s):

Cytochrome P450 ◽

Human Liver ◽

Microsomal Cytochrome ◽

Interaction of selected platinum(II) complexes containing roscovitine-based CDK inhibitors as ligands with human liver microsomal cytochrome P450

Biomedical Papers ◽

10.5507/bp.2014.031 ◽

2015 ◽

Vol 159 (3) ◽

pp. 382-387

Author(s):

Vlastimil Masek ◽

Pavel Starha ◽

Monika Harvanova ◽

Martina Michalova ◽

David Milde ◽

...

Keyword(s):

Cytochrome P450 ◽

Human Liver ◽

Cdk Inhibitors ◽

Microsomal Cytochrome ◽

Human liver microsomal cytochrome P450 3A isozymes mediated vindesine biotransformation

Biochemical Pharmacology ◽

10.1016/0006-2952(93)90169-w ◽

1993 ◽

Vol 45 (4) ◽

pp. 853-861 ◽

Cited By ~ 51

Author(s):

Xiao-Jian Zhou ◽

Xin-Ru Zhou-Pan ◽

Thérése Gauthier ◽

Michel Placidi ◽

Patrick Maurel ◽

...

Keyword(s):

Cytochrome P450 ◽

Human Liver ◽

Cytochrome P450 3A ◽

Microsomal Cytochrome ◽

Generation of a free radical from calphostin C by microsomal cytochrome P450 reductase in rat and human liver

Biochemical Pharmacology ◽

10.1016/s0006-2952(95)02180-9 ◽

1996 ◽

Vol 51 (5) ◽

pp. 599-603 ◽

Cited By ~ 3

Author(s):

Laurence H. Patterson ◽

Sarah Jones ◽

Andreas Gescher

Keyword(s):

Cytochrome P450 ◽

Free Radical ◽

Human Liver ◽

Cytochrome P450 Reductase ◽

Microsomal Cytochrome ◽

Calphostin C ◽

P450 Reductase ◽

Human liver microsomal cytochrome P450 and B5 act as reductases in the reductive metabolism of 3′-azido-3′-deoxythymidine to 3′-amino-3′deoxythymidine.

Clinical Pharmacology & Therapeutics ◽

10.1038/sj.clpt.1996.171 ◽

1996 ◽

Vol 59 (2) ◽

pp. 168-168 ◽

Cited By ~ 1

Author(s):

X.R. Pan-Zhou ◽

E. Cretton-Scott ◽

X.J. Zhou ◽

M.X. Yang ◽

J. M. Lasker ◽

...

Keyword(s):

Cytochrome P450 ◽

Human Liver ◽

Microsomal Cytochrome ◽

Reductive Metabolism

Human Liver Microsomal Cytochrome P450 3A Enzymes Involved in Thalidomide 5-Hydroxylation and Formation of a Glutathione Conjugate

Chemical Research in Toxicology ◽

10.1021/tx900367p ◽

2010 ◽

Vol 23 (6) ◽

pp. 1018-1024 ◽

Cited By ~ 31

Author(s):

Goutam Chowdhury ◽

Norie Murayama ◽

Yusuke Okada ◽

Yasuhiro Uno ◽

Makiko Shimizu ◽

...

Keyword(s):

Cytochrome P450 ◽

Human Liver ◽

Cytochrome P450 3A ◽

Glutathione Conjugate ◽

Microsomal Cytochrome ◽

Mass spectrometry-based absolute quantification of microsomal cytochrome P450 2D6 in human liver

PROTEOMICS ◽

10.1002/pmic.200800680 ◽

2009 ◽

Vol 9 (9) ◽

pp. 2313-2323 ◽

Cited By ~ 59

Author(s):

Elmar Langenfeld ◽

Ulrich M. Zanger ◽

Klaus Jung ◽

Helmut E. Meyer ◽

Katrin Marcus

Keyword(s):

Mass Spectrometry ◽

Cytochrome P450 ◽

Human Liver ◽

Absolute Quantification ◽

Cytochrome P450 2D6 ◽

Microsomal Cytochrome ◽

P450 2D6

[21] Measurement of human liver microsomal cytochrome P450 2D6 activity using [O-methyl-14C]dextromethorphan as substrate

Methods in Enzymology - Cytochrome P450, Part B ◽

10.1016/s0076-6879(96)72023-2 ◽

1996 ◽

pp. 186-195 ◽

Cited By ~ 13

Author(s):

A. David Rodrigues

Keyword(s):

Cytochrome P450 ◽

Human Liver ◽

Cytochrome P450 2D6 ◽

Microsomal Cytochrome ◽

P450 2D6