Paraoxonase 1 polymorphisms and haplotypes and the risk for having offspring affected with spina bifida in Southeast Mexico

2010 ◽  
Vol 88 (11) ◽  
pp. 987-994 ◽  
Author(s):  
Lizbeth Gonzalez-Herrera ◽  
Ricardo Martín Cerda-Flores ◽  
Marianne Luna-Rivero ◽  
Jorge Canto-Herrera ◽  
Doris Pinto-Escalante ◽  
...  
Keyword(s):  
Spina Bifida ◽  
Paraoxonase 1 ◽  
Southeast Mexico

Paraoxonase 1 (PON1) polymorphisms and haplotypes as risk factors for having Spina bifida-affected offspring in southeast Mexico

2010 ◽  
Vol 196 ◽  
pp. S45-S46
Author(s):  
B. Quintanilla-Vega ◽  
L. González-Herrera ◽  
J. Canto-Herrera ◽  
D. Pinto-Escalante ◽  
R. Cerda-Flores
Keyword(s):  
Risk Factors ◽  
Spina Bifida ◽  
Paraoxonase 1 ◽  
Affected Offspring ◽  
Pon1 Polymorphisms ◽  
Southeast Mexico

scholarly journals Association of A80G Polymorphism in the RFC1 Gene with the Risk for Having Spina Bifida-Affected Offspring in Southeast Mexico and Interaction with C677T-MTHFR

10.5772/31375 ◽  
2012 ◽  
Author(s):  
Lizbeth Gonzlez-Herrera ◽  
Orlando Vargas-Sierra ◽  
Silvina Contreras-Capetillo ◽  
Gerardo Prez-Mendoza ◽  
Ileana Castillo-Zapata ◽  
...  
Keyword(s):  
Spina Bifida ◽  
Affected Offspring ◽  
C677t Mthfr ◽  
Southeast Mexico

Homocysteine thiolactonase activity of paraoxonase 1 in heart failure patients

2008 ◽  
Vol 7 ◽  
pp. 141-141
Author(s):  
E MOLDOVEANU ◽  
D MARTA ◽  
C TANASEANU ◽  
M SERBAN ◽  
I SERBAN ◽  
...  
Keyword(s):  
Heart Failure ◽  
Paraoxonase 1 ◽  
Heart Failure Patients ◽  
Homocysteine Thiolactonase

Paraoxonase-1 and myeloperoxidase correlate with vascular biomarkers in overweight patients with newly diagnosed untreated hyperlipidaemia

VASA ◽  
2017 ◽  
Vol 46 (5) ◽  
pp. 370-376 ◽  
Author(s):  
Anita Szentpéteri ◽  
Noémi Zsíros ◽  
Viktória E. Varga ◽  
Hajnalka Lőrincz ◽  
Mónika Katkó ◽  
...  
Keyword(s):  
Adhesion Molecule ◽  
Oxidized Ldl ◽  
Vascular Complications ◽  
Cd40 Ligand ◽  
Paraoxonase 1 ◽  
Intercellular Adhesion Molecule ◽  
Pon1 Activity ◽  
Intercellular Adhesion Molecule 1 ◽  
Inflammatory Parameters ◽  
Vascular Biomarkers

Abstract. Background: In hyperlipidaemic state, increased levels of myeloperoxidase (MPO) and decreased paraoxonase-1 (PON1) activity have been reported; however, their relationships with other atherosclerotic biomarkers have not been completely clarified. Patients and methods: Serum concentrations of lipid and inflammatory parameters, MPO levels, and PON1 activities were investigated in 167 untreated hyperlipidaemic patients with and without vascular complications and in 32 healthy controls. Additionally, levels of CD40 ligand (sCD40L) and asymmetric dimethyl arginine (ADMA), soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1, and oxidized LDL were determined. Results: We found elevated C-reactive protein (CRP), ADMA, sCD40L, sICAM-1 concentrations, and higher MPO levels in patients with vascular complications compared to those without. The PON1 arylesterase activity correlated negatively with sCD40L, ADMA, and sICAM-1 levels, respectively. In contrast, MPO concentrations showed positive correlations with sCD40L, ADMA, and sICAM-1 levels, respectively. Conclusions: It can therefore be stated that PON1 activity and MPO level correlate strongly with the vascular biomarkers, highlighting the importance of the HDL-associated pro- and antioxidant enzymes in the development of endothelial dysfunction and atherogenesis.

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