Fibrosis-associated gene expression in renal transplant glomeruli after acute renal allograft rejection

2003 ◽  
Vol 90 (8) ◽  
pp. 1009-1014 ◽  
Author(s):  
N. R. Brook ◽  
S. A. White ◽  
J. R. Waller ◽  
G. R. Bicknell ◽  
M. L. Nicholson
Keyword(s):  
Gene Expression ◽  
Renal Transplant ◽  
Allograft Rejection ◽  
Renal Allograft ◽  
Renal Allograft Rejection ◽  
Acute Renal Allograft Rejection

Effects of Sample Timing and Treatment on Gene Expression in Early Acute Renal Allograft Rejection

2011 ◽  
Vol 91 (3) ◽  
pp. 323-329 ◽  
Author(s):  
Oliver P. Günther ◽  
David Lin ◽  
Robert F. Balshaw ◽  
Raymond T. Ng ◽  
Zsuzsanna Hollander ◽  
...  
Keyword(s):  
Gene Expression ◽  
Allograft Rejection ◽  
Renal Allograft ◽  
Renal Allograft Rejection ◽  
Acute Renal Allograft Rejection

CYTOTOXIC EFFECTOR MOLECULE GENE EXPRESSION IN ACUTE RENAL ALLOGRAFT REJECTION

2001 ◽  
Vol 72 (6) ◽  
pp. 1158-1161 ◽  
Author(s):  
Peter Nickel ◽  
Jiri Lacha ◽  
Susanne Ode-Hakim ◽  
Birgit Sawitzki ◽  
Nina Babel ◽  
...  
Keyword(s):  
Gene Expression ◽  
Allograft Rejection ◽  
Renal Allograft ◽  
Effector Molecule ◽  
Renal Allograft Rejection ◽  
Acute Renal Allograft Rejection ◽  
Cytotoxic Effector

scholarly journals Longitudinal Analysis of Whole Blood Transcriptomes to Explore Molecular Signatures Associated with Acute Renal Allograft Rejection

2014 ◽  
Vol 8 ◽  
pp. BBI.S13376 ◽  
Author(s):  
Heesun Shin ◽  
Oliver GÜnther ◽  
Zsuzsanna Hollander ◽  
Janet E. Wilson-Mcmanus ◽  
Raymond T. Ng ◽  
...  
Keyword(s):  
Gene Expression ◽  
Acute Rejection ◽  
Whole Blood ◽  
Allograft Rejection ◽  
Time Course ◽  
Renal Allograft ◽  
Acute Rejection Episode ◽  
Renal Allograft Rejection ◽  
Expression Signature ◽  
Acute Renal Allograft Rejection

In this study, we explored a time course of peripheral whole blood transcriptomes from kidney transplantation patients who either experienced an acute rejection episode or did not in order to better delineate the immunological and biological processes measureable in blood leukocytes that are associated with acute renal allograft rejection. Using microarrays, we generated gene expression data from 24 acute rejectors and 24 nonrejectors. We filtered the data to obtain the most unambiguous and robustly expressing probe sets and selected a subset of patients with the clearest phenotype. We then performed a data-driven exploratory analysis using data reduction and differential gene expression analysis tools in order to reveal gene expression signatures associated with acute allograft rejection. Using a template-matching algorithm, we then expanded our analysis to include time course data, identifying genes whose expression is modulated leading up to acute rejection. We have identified molecular phenotypes associated with acute renal allograft rejection, including a significantly upregulated signature of neutrophil activation and accumulation following transplant surgery that is common to both acute rejectors and nonrejectors. Our analysis shows that this expression signature appears to stabilize over time in nonrejectors but persists in patients who go on to reject the transplanted organ. In addition, we describe an expression signature characteristic of lymphocyte activity and proliferation. This lymphocyte signature is significantly downregulated in both acute rejectors and nonrejectors following surgery; however, patients who go on to reject the organ show a persistent downregulation of this signature relative to the neutrophil signature.

Triple drug Therapy for the Prevention of Early Acute Renal Allograft Rejection in Dogs

2010 ◽  
Vol 41 (1) ◽  
pp. 9-16
Author(s):  
Masaaki KATAYAMA ◽  
Kazuhiro FUKAI ◽  
Hiroyuki IGARASHI ◽  
Kenji TANI ◽  
Yutaka MOMOTA ◽  
...  
Keyword(s):  
Drug Therapy ◽  
Allograft Rejection ◽  
Renal Allograft ◽  
Renal Allograft Rejection ◽  
Acute Renal Allograft Rejection

ROLE OF XANTHINE OXIDOREDUCTASE IN EXPERIMENTAL ACUTE RENAL-ALLOGRAFT REJECTION

2004 ◽  
Vol 77 (11) ◽  
pp. 1683-1692 ◽  
Author(s):  
Kai Sun ◽  
Eva Kiss ◽  
Jens Bedke ◽  
Tomislav Stojanovic ◽  
Yanhua Li ◽  
...  
Keyword(s):  
Allograft Rejection ◽  
Renal Allograft ◽  
Xanthine Oxidoreductase ◽  
Renal Allograft Rejection ◽  
Acute Renal Allograft Rejection

scholarly journals Renal and Urinary Levels of Endothelial Protein C Receptor Correlate with Acute Renal Allograft Rejection

PLoS ONE ◽  
2013 ◽  
Vol 8 (5) ◽  
pp. e64994 ◽  
Author(s):  
Lionel Lattenist ◽  
Jesper Kers ◽  
Nike Claessen ◽  
Ineke J. M. ten Berge ◽  
Frederike J. Bemelman ◽  
...  
Keyword(s):  
Allograft Rejection ◽  
Protein C ◽  
Renal Allograft ◽  
Endothelial Protein C Receptor ◽  
Renal Allograft Rejection ◽  
Acute Renal Allograft Rejection ◽  
Urinary Levels

Blocking of CCR5 and CXCR3 Suppresses the Infiltration of Macrophages in Acute Renal Allograft Rejection

2012 ◽  
Vol 93 (1) ◽  
pp. 24-31 ◽  
Author(s):  
Yoichi Kakuta ◽  
Masayoshi Okumi ◽  
Shuji Miyagawa ◽  
Koichi Tsutahara ◽  
Toyofumi Abe ◽  
...  
Keyword(s):  
Allograft Rejection ◽  
Renal Allograft ◽  
Renal Allograft Rejection ◽  
Acute Renal Allograft Rejection

Genetic Polymorphisms of Immunoregulatory Proteins in Acute Renal Allograft Rejection

2009 ◽  
Vol 41 (8) ◽  
pp. 3305-3307 ◽  
Author(s):  
H. Krichen ◽  
I. Sfar ◽  
S. Jendoubi-Ayed ◽  
M. Makhlouf ◽  
T. Ben Rhomdhane ◽  
...  
Keyword(s):  
Genetic Polymorphisms ◽  
Allograft Rejection ◽  
Renal Allograft ◽  
Renal Allograft Rejection ◽  
Acute Renal Allograft Rejection
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