scholarly journals Machine learning is a valid method for predicting prehospital delay after acute ischemic stroke

2020 ◽  
Vol 10 (10) ◽  
Author(s):  
Li Yang ◽  
Qinqin Liu ◽  
Qiuli Zhao ◽  
Xuemei Zhu ◽  
Ling Wang
Keyword(s):  
Machine Learning ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Prehospital Delay ◽  
Valid Method

Author response for "Machine learning is a valid method for predicting prehospital delay after acute ischemic stroke"

2020 ◽  
Author(s):  
Li Yang ◽  
Qinqin Liu ◽  
Qiuli Zhao ◽  
Xuemei Zhu ◽  
Ling Wang
Keyword(s):  
Machine Learning ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Author Response ◽  
Prehospital Delay ◽  
Valid Method

Reperfusion Therapy in Acute Ischemic Stroke with Active Cancer: A Meta-Analysis Aided by Machine Learning

2021 ◽  
Vol 30 (6) ◽  
pp. 105742
Author(s):  
Mi-Yeon Eun ◽  
Eun-Tae Jeon ◽  
Kwon-Duk Seo ◽  
Dongwhane Lee ◽  
Jin-Man Jung
Keyword(s):  
Machine Learning ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Meta Analysis ◽  
Reperfusion Therapy ◽  
Active Cancer

Abstract TP215: Machine Learning Analysis of Gene Expression Data and Predictive Stroke Outcomes in Acute Ischemic Stroke

Stroke ◽  
2020 ◽  
Vol 51 (Suppl_1) ◽  
Author(s):  
Sarah R Martha ◽  
Qiang Cheng ◽  
Liyu Gong ◽  
Lisa Collier ◽  
Stephanie Davis ◽  
...  
Keyword(s):  
Gene Expression ◽  
Machine Learning ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Mechanical Thrombectomy ◽  
Stroke Patients ◽  
Stroke Outcomes ◽  
Inflammatory Genes ◽  
Patient Demographics ◽  
Edema Volume

Background and Purpose: The ability to predict ischemic stroke outcomes in the first day of admission could be vital for patient counseling, rehabilitation, and care planning. The Blood and Clot Thrombectomy Registry and Collaboration (BACTRAC; clinicaltrials.gov NCT03153683) collects blood samples distal and proximal to the intracranial thrombus during mechanical thrombectomy. These samples are a novel resource in evaluating acute gene expression changes at the time of ischemic stroke. The purpose of this study was to identify inflammatory genes and patient demographics that are predictive of stroke outcomes (infarct and/or edema volume) in acute ischemic stroke patients. Methods: The BACTRAC study is a non-probability, convenience sampling of subjects (≥ 18 year olds) treated with mechanical thrombectomy for emergent large vessel occlusion. We evaluated relative concentrations of mRNA for gene expression in 84 inflammatory molecules in static blood distal and proximal to the intracranial thrombus from adults who underwent thrombectomy. We employed a machine learning method, Random Forest, utilizing the first set of enrolled subjects, to predict which inflammatory genes and patient demographics were important features for infarct and edema volumes. Results: We analyzed the first 28 subjects (age = 66 ± 15.48, 11 males) in the BACTRAC registry. Results from machine learning analyses demonstrate that the genes CCR4, IFNA2, IL9, CXCL3, Age, DM, IL7, CCL4, BMI, IL5, CCR3, TNF, and IL27 predict infarct volume. The genes IFNA2, IL5, CCL11, IL17C, CCR4, IL9, IL7, CCR3, IL27, DM, and CSF2 predict edema volume. There is an intersection of genes CCR4, IFNA2, IL9, IL7, IL5, CCR3 to both infarct and edema volumes. Overall, these genes depicts a microenvironment for chemoattraction and proliferation of autoimmune cells, particularly Th2 cells and neutrophils. Conclusions: Machine learning algorithms can be employed to develop predictive biomarker signatures for stroke outcomes in ischemic stroke patients, particularly in regard to identifying acute gene expression changes that occur during stroke.

Abstract WMP23: Automated ASPECTS Scoring of CT Scans for Acute Ischemic Stroke Patients Using Machine Learning

Stroke ◽  
2018 ◽  
Vol 49 (Suppl_1) ◽  
Author(s):  
Hulin Kuang ◽  
Ericka Teleg ◽  
Mohamed Najm ◽  
Alexis T Wilson ◽  
Sung I Sohn ◽  
...  
Keyword(s):  
Machine Learning ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Ct Scans ◽  
Stroke Patients

scholarly journals Reasons for Prehospital Delay in Acute Ischemic Stroke

2019 ◽  
Vol 8 (20) ◽  
Author(s):  
Joachim Fladt ◽  
Nicole Meier ◽  
Sebastian Thilemann ◽  
Alexandros Polymeris ◽  
Christopher Traenka ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Prehospital Delay

scholarly journals Status of prehospital delay and intravenous thrombolysis in the management of acute ischemic stroke in Nepal

BMC Neurology ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Gaurav Nepal ◽  
Jayant Kumar Yadav ◽  
Babin Basnet ◽  
Tirtha Man Shrestha ◽  
Ghanshyam Kharel ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Intravenous Thrombolysis ◽  
Prehospital Delay
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