Review for "Adjunctive bright light therapy for treating bipolar depression: A systematic review and meta‐analysis of randomized controlled trials"

2020 ◽  
Keyword(s):  
Systematic Review ◽  
Randomized Controlled Trials ◽  
Bipolar Depression ◽  
Meta Analysis ◽  
Bright Light ◽  
Light Therapy ◽  
Controlled Trials ◽  
Bright Light Therapy ◽  
Randomized Controlled

scholarly journals Adjunctive bright light therapy for treating bipolar depression: A systematic review and meta‐analysis of randomized controlled trials

2020 ◽  
Vol 10 (12) ◽  
Author(s):  
Hirofumi Hirakawa ◽  
Takeshi Terao ◽  
Masaaki Muronaga ◽  
Nobuyoshi Ishii
Keyword(s):  
Systematic Review ◽  
Randomized Controlled Trials ◽  
Bipolar Depression ◽  
Meta Analysis ◽  
Bright Light ◽  
Light Therapy ◽  
Controlled Trials ◽  
Bright Light Therapy ◽  
Randomized Controlled

scholarly journals Bright Light Therapy for Parkinson Disease: A Literature Review and Meta-Analysis of Randomized Controlled Trials

Biology ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 1205
Author(s):  
Hsu-Tung Huang ◽  
Tsai-Wei Huang ◽  
Chien-Tai Hong
Keyword(s):  
Literature Review ◽  
Parkinson Disease ◽  
Randomized Controlled Trials ◽  
Meta Analysis ◽  
Bright Light ◽  
Light Therapy ◽  
Controlled Trials ◽  
Motor Symptoms ◽  
Bright Light Therapy ◽  
Randomized Controlled

Sleep disorders and depression are significant nonmotor symptoms (NMSs) of Parkinson disease (PD). However, few effective, evidence-proven medical treatments are available for alleviating these symptoms. Bright light therapy (BLT) is a well-established treatment for circadian rhythm sleep disorders and seasonal affective disorder. The present study conducted a literature review for the effect of BLT on PD, especially a meta-analysis of randomized controlled trials (RCTs). We searched for studies using the PubMed and Cochrane Library databases. The major outcomes were the effects on sleep and depression. The effect on motor symptoms was also analyzed as a secondary outcome. This study was registered with PROSPERO (CRD42020204454). Six studies were included in the literature review only, and the other five RCTs were included in the meta-analysis. Despite the positive effects of BLT on PD patients, which were demonstrated in noncontrolled studies, in the meta-analysis of the RCTs, BLT did not significantly improve the depressive symptoms (standardized mean difference (SMD): −0.15, 95% confidence interval (CI): −0.48 to 0.17, p = 0.36) and excessive daytime sleepiness (EDS) (SMD: −0.12, 95% CI: −0.49 to 0.25, p = 0.53) in PD patients. Regarding motor symptoms, no significant beneficial effects were conferred (SMD: −0.11, 95% CI: −0.44 to 0.21, p = 0.49). In conclusion, BLT did not significantly alleviate depression and sleepiness. The inconsistency between BLT protocols, such as the varied timing, dosages, and treatment durations, may render BLT’s efficacy difficult to demonstrate. The small effect size obtained from the present meta-analysis indicates that future RCTs are necessary, for which BLT protocols are standardized and more patients are enrolled to determine whether a significant therapeutic benefit was conferred.

scholarly journals Light Therapy Reduces Fatigue in Patients With Cancer: Protocol for a Systematic Review and Meta-analysis

2021 ◽  
Author(s):  
Panpan Xiao ◽  
Siqing Ding ◽  
Yinglong Duan ◽  
Lijun Li ◽  
Yi Zhou ◽  
...  
Keyword(s):  
Systematic Review ◽  
Randomized Controlled Trials ◽  
Cancer Patients ◽  
Meta Analysis ◽  
Light Therapy ◽  
Cochrane Library ◽  
Controlled Trials ◽  
Cochrane Central Register ◽  
Randomized Controlled ◽  
Review Team

Abstract BackgroundFatigue is a common symptom in cancer patients that can occur throughout the course of cancer, with a prevalence ranging from 75% to 100%. Nonpharmacological intervention is currently mainly used to address cancer-related fatigue (CRF). Light therapy has been gradually used to treat CRF and has been found to be effective. However, to date, there is no systematic review on light therapies for reducing CRF to verify its effectiveness. This is a protocol for a systematic review that aims to evaluate the effectiveness of light therapies for treating fatigue in cancer survivors. This systematic review protocol was registered with the International Prospective Register of Systematic Reviews (PROSPERO) database.MethodsThis protocol was designed in accordance with the PRISMA-P guidelines. We will search the PubMed, Cochrane Central Register of Controlled Trials (CENTRAL; The Cochrane Library), Embase (OVID), and CINAHL databases as well as relevant sources of gray literature. Randomized controlled trials (RCTs) and quasi-experimental trials that have evaluated the use of light therapy among cancer patients at any survival phase, with fatigue as an outcome measure, will be included. Two members of the review team will independently extract data from the selected studies and assess their methodological quality using the Cochrane Collaboration Risk of Bias Tool.DiscussionThis systematic review and meta-analysis will build upon previous evaluations of light therapies in patients during and after cancer treatment. Due to the multifactorial nature of CRF and the growing demand for etiological-based intervention research, this review seeks to highlight a gap in current practice and to strengthen the evidence base of randomized controlled trials in the area.Systematic review registrationCRD42020215446

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