What are the effects of dupilumab for adults with chronic rhinosinusitis and nasal polyps who are taking intranasal steroids?

2021 ◽  
Author(s):  
Adarsh Gupta
Keyword(s):  
Chronic Rhinosinusitis ◽  
Nasal Polyps ◽  
Intranasal Steroids

Biological therapy of chronic rhinosinusitis

2021 ◽  
Vol 70 (2) ◽  
pp. 109-114
Author(s):  
Zuzana Balatková ◽  
Zdeněk Knížek ◽  
Jan Vodička ◽  
Jan Plzák
Keyword(s):  
Chronic Rhinosinusitis ◽  
Nasal Polyps ◽  
Biological Therapy ◽  
Immunoglobulin E ◽  
Sinus Surgery ◽  
Therapeutic Choice ◽  
First Choice ◽  
Intranasal Steroids

The aim of this paper is to present an up-to-date information about therapeutical options in chronic rhinosinusitis with nasal polyps. First choice therapy is a long term regular application of intranasal steroids in combination with salinic solution douches. If this treatment is not eff ective enough, then the pulses of systemic steroids are indicated. If the sufficient control of the disease is not achieved, then surgery is a therapeutic choice; it means functional endoscopic sinus surgery in the extent corresponding to the extension of the sinus disease. However, there remains a certain group of patients in whom the results with this treatment are not optimal. The type 2 immunopathological response affects relevantly the course of the disease. Nowadays, the research is done in this field. Specific agents, which are able to block circulating inflammatory mediators or bind receptors for these mediators are developed and studied. The results of the studies having been completed by now are promising. Keywords: biological therapy – chronic rhinosinusitis – nasal polyps – dupilumab – immunoglobulin E – interleukin

ESTIMATION OF ENDOSCOPIC SYNUSOTHOMY EFFICIENCY IN CHRONIC RHINOSINUSITIS WITH NASAL POLYPS BASED ON DATA OF ENT CLINIC OF PUBLIC INSTITUTION «NATIONAL MEDICAL CENTER» OF THE REPUBLIC OF TAJIKISTAN

2017 ◽  
Vol 19 (1) ◽  
Author(s):  
Mahmadulo Ikromov ◽  
◽  
Diloshub Davlatov ◽  
Mohira Nazirmadova ◽  
Abduzokir Abduhalilov ◽  
...  
Keyword(s):  
Chronic Rhinosinusitis ◽  
Nasal Polyps ◽  
Medical Center ◽  
Public Institution ◽  
National Medical ◽  
The Republic
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