Inside Back Cover: Design of Na+
-Selective Fluorescent Probes: A Systematic Study of the Na+
-Complex Stability and the Na+
/K+
 Selectivity in Acetonitrile and Water (Chem. Eur. J. 30/2017)

The ever-growing demand for fluorogenic dyes usable in the rapid construction of analyte-responsive fluorescent probes, has recently contributed to a revival of interest in the chemistry of diketopyrrolopyrrole (DPP) pigments. In this context, we have explored the potential of symmetrical and unsymmetrical DPP derivatives bearing two or one 4-pyridyl substituents acting as optically tunable group(s). The unique fluorogenic behavior of these molecules, closely linked to N-substitution/charge state of their pyridine unit (i.e., neutral pyridine or cationic pyridinium), has been used to design DPP-based fluorescent probes for detection of hypoxia-related redox enzymes and penicillin G acylase (PGA). In this paper, we describe synthesis, spectral characterization and bioanalytical validations of these probes. Dramatic differences in terms of aqueous stability and enzymatic fluorescence activation were observed. This systematic study enables to delineate the scope of application of pyridine-flanked DPP fluorophores in the field of enzyme biosensing.

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Back Cover: Design of Artificial Metabolisms in Layered Nanomaterials for the Enzymatic Synthesis of Phosphorylated Sugars (ChemCatChem 19/2015)

ChemCatChem ◽

10.1002/cctc.201501033 ◽

2015 ◽

Vol 7 (19) ◽

pp. 3187-3187 ◽

Cited By ~ 1

Author(s):

Rima Mahdi ◽

Christine Guérard-Hélaine ◽

Vanessa Prévot ◽

Véronique de Berardinis ◽

Claude Forano ◽

...

Keyword(s):

Enzymatic Synthesis ◽

Back Cover ◽

Cover Design ◽

Phosphorylated Sugars

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Inside Back Cover: Design and maskless fabrication of ultrathin suspended membranes of GaN (Phys. Status Solidi RRL 4/2012)

physica status solidi (RRL) - Rapid Research Letters ◽

10.1002/pssr.201290008 ◽

2012 ◽

Vol 6 (4) ◽

pp. n/a-n/a

Author(s):

I. M. Tiginyanu ◽

V. Popa ◽

M. A. Stevens-Kalceff ◽

D. Gerthsen ◽

P. Brenner ◽

...

Keyword(s):

Back Cover ◽

Cover Design

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Back Cover: Design of a Silver-Cerium Dioxide Core-Shell Nanocomposite Catalyst for Chemoselective Reduction Reactions (Angew. Chem. Int. Ed. 1/2012)

Angewandte Chemie International Edition ◽

10.1002/anie.201107546 ◽

2011 ◽

Vol 51 (1) ◽

pp. 278-278 ◽

Cited By ~ 2

Author(s):

Takato Mitsudome ◽

Yusuke Mikami ◽

Motoshi Matoba ◽

Tomoo Mizugaki ◽

Koichiro Jitsukawa ◽

...

Keyword(s):

Cerium Dioxide ◽

Core Shell ◽

Reduction Reactions ◽

Back Cover ◽

Nanocomposite Catalyst ◽

Cover Design

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Design, Synthesis and Evaluation of Enzyme-Responsive Fluorogenic Probes Based on Pyridine-Flanked Diketopyrrolopyrrole Dyes

10.26434/chemrxiv.13008524.v1 ◽

2020 ◽

Author(s):

Sébastien Jenni ◽

Flavien Ponsot ◽

Pierre Baroux ◽

Lucille Collard ◽

Takayuki Ikeno ◽

...

Keyword(s):

Charge State ◽

Systematic Study ◽

Fluorescent Probes ◽

Penicillin G ◽

Redox Enzymes ◽

Design Synthesis ◽

Rapid Construction ◽

Fluorogenic Dyes ◽

Fluorogenic Probes ◽

Scope Of Application

The ever-growing demand for fluorogenic dyes usable in the rapid construction of analyte-responsive fluorescent probes, has recently contributed to a revival of interest in the chemistry of diketopyrrolopyrrole (DPP) pigments. In this context, we have explored the potential of symmetrical and unsymmetrical DPP derivatives bearing two or one 4-pyridyl substituents acting as optically tunable group(s). The unique fluorogenic behavior of these molecules, closely linked to N-substitution/charge state of their pyridine unit (i.e., neutral pyridine or cationic pyridinium), has been used to design DPP-based fluorescent probes for detection of hypoxia-related redox enzymes and penicillin G acylase (PGA). In this paper, we describe synthesis, spectral characterization and bioanalytical validations of these probes. Dramatic differences in terms of aqueous stability and enzymatic fluorescence activation were observed. This systematic study enables to delineate the scope of application of pyridine-flanked DPP fluorophores in the field of enzyme biosensing.

Download Full-text