ChemInform Abstract: NPE-Resin, a New Approach to the Solid-Phase Synthesis of Protected Peptides and Oligonucleotides. Part 1. Synthesis of the Supports and Their Application to Oligonucleotide Synthesis.

ChemInform ◽  
2010 ◽  
Vol 23 (2) ◽  
pp. no-no
Author(s):  
R. ERITJA ◽  
J. ROBLES ◽  
D. FERNANDEZ-FORNER ◽  
F. ALBERICIO ◽  
E. GIRALT ◽  
...  
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Oligonucleotide Synthesis ◽  
New Approach ◽  
Phase Synthesis ◽  
Protected Peptides

NPE-resin, a new approach to the solid-phase synthesis of protected peptides and oligonucleotides

Peptides 1990 ◽  
1991 ◽  
pp. 134-136 ◽  
Author(s):  
Fernando Albericio ◽  
Jordi Robles ◽  
Dolors Fernandez-Forner ◽  
Yolanda Palom ◽  
Carles Celma ◽  
...  
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
New Approach ◽  
Phase Synthesis ◽  
Protected Peptides

Improved Conditions for Solid Phase Synthesis of Oligonucleotides on PS-PEG Copolymers

1995 ◽  
Vol 50 (7) ◽  
pp. 1096-1100 ◽  
Author(s):  
Ernst Bayer ◽  
Konrad Bleicher ◽  
Martin Maier
Keyword(s):  
Electrospray Mass Spectrometry ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Chemical Properties ◽  
Oligonucleotide Synthesis ◽  
Phase Synthesis ◽  
Controlled Pore Glass ◽  
Product Identification ◽  
Pore Glass ◽  
And Chemical Properties

Polystyrene-polyethylene glycol (PS-PEG) tentacle polymers with loadings of up to 60/<μmol/g were used for standard oligonucleotide synthesis. As these resins are easy to handle and stable under reaction and cleavage conditions they may be used alternatively to controlled pore glass (CPG) as the most commonly used solid support for oligonucleotide synthesis. However, structural and chemical properties of the PS-PEG resins require modified conditions to guarantee syntheses with high coupling efficiencies. Oligonucleotides (ODN ) of various sequences and lengths have successfully been synthesized using HPLC and capillary electrophoresis (CE) for purity control. Additionally, electrospray mass spectrometry (ES-MS) was used for product identification.

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