Post-Synthetic Functionalization of Tryptophan Protected Peptides Sequences through Indole (C-2) Photocatalytic Alkylation

We report a selective, mild, and efficient C-H functionalization of tryptophan and of tryptophan-containing peptides with activated α-bromo-carbonyl compounds under visible-light irradiation. The protocol is valued by the wide substrate...

Cleaving protected peptides from 2-chlorotrityl chloride resin. Moving away from dichloromethane

Anisole and 1,3-dimethoybenzene are excellent alternatives to DCM for cleaving protected peptides.

Direct palladium-mediated on-resin disulfide formation from Allocam protected peptides

We present a mild, convenient method for direct conversion of Allocam protected peptides to disulfide-containing protected peptides on solid support.

C-Terminally modified peptides via cleavage of the HMBA linker by O-, N- or S-nucleophiles

A direct and convenient method for the release of protected peptides with C-terminal modification from the HMBA linker by nucleophilic cleavage with amines, alcoholates or thiolates.

Automated synthesis of backbone protected peptides

The automated introduction of removable substitution along a peptide backbone prevents chain-association and synthesis failure.