ChemInform Abstract: Asymmetric Synthesis of Nitrogen-Containing Biologically Active Compounds Utilizing Intramolecular Aminocyclization to Olefin of Secondary Allylic Alcohols

ChemInform ◽  
2010 ◽  
Vol 23 (35) ◽  
pp. no-no
Author(s):  
H. TAKAHATA
Keyword(s):  
Asymmetric Synthesis ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Allylic Alcohols ◽  
Active Compounds

Use of chiral auxiliaries in the asymmetric synthesis of biologically active compounds: A review

Chirality ◽  
2019 ◽  
Vol 31 (10) ◽  
pp. 776-812 ◽  
Author(s):  
Gaspar Diaz‐Muñoz ◽  
Izabel Luzia Miranda ◽  
Suélen Karine Sartori ◽  
Daniele Cristina Rezende ◽  
Marisa Alves Nogueira Diaz
Keyword(s):  
Asymmetric Synthesis ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Chiral Auxiliaries ◽  
Active Compounds

Recent Advances in the Catalytic Asymmetric Construction of Phosphorus-Substituted Quaternary Carbon Stereocenters

Synthesis ◽  
2017 ◽  
Vol 50 (03) ◽  
pp. 440-469 ◽  
Author(s):  
Long Chen
Keyword(s):  
Asymmetric Synthesis ◽  
Reaction Mechanisms ◽  
Recent Progress ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Quaternary Carbon ◽  
Active Compounds ◽  
Catalytic Asymmetric Synthesis ◽  
Stereogenic Centers ◽  
Catalytic Asymmetric

Phosphorus-substituted quaternary carbon stereocenters exist widely in drugs and biologically active compounds. Catalytic asymmetric synthesis of such quaternary carbon stereogenic centers is of significant importance, with four synthetic strategies being established. This review summarizes the recent progress in this field, including the advantages and limitations of each strategy, briefly discusses the reaction mechanisms and challenges, and outlines synthetic opportunities still open.1 Introduction2 Asymmetric Hydrophosphonylation3 Asymmetric Electrophilic Phosphination4 Asymmetric Functionalization of P-Substituted Methine Compounds5 Asymmetric Addition to α-Keto- or α-Ketiminophosphonates6 Conclusion

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