ChemInform Abstract: Expedient Asymmetric Synthesis of (2S,3S)-Boc-phenylalanine Epoxide (X), a Key Intermediate for the Synthesis of Biologically Active Compounds.

ChemInform ◽  
2010 ◽  
Vol 41 (12) ◽  
Author(s):  
Ramon Badorrey ◽  
Maria D. Diaz-de-Villegas ◽  
Jose A. Galvez
Keyword(s):  
Asymmetric Synthesis ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Active Compounds

ChemInform Abstract: Asymmetric Synthesis of Biologically Active Compounds Bearing a Chiral Sulfinyl Group

ChemInform ◽  
2010 ◽  
Vol 24 (23) ◽  
pp. no-no
Author(s):  
N. KHIAR ◽  
I. FERNANDEZ ◽  
F. ALCUDIA
Keyword(s):  
Asymmetric Synthesis ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Active Compounds ◽  
Sulfinyl Group

Asymmetric Synthesis of Biologically Active Compounds

ChemInform ◽  
2004 ◽  
Vol 35 (50) ◽  
Author(s):  
Henri Kagan
Keyword(s):  
Asymmetric Synthesis ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Active Compounds

Expedient asymmetric synthesis of (2S,3S)-Boc-phenylalanine epoxide, a key intermediate for the synthesis of biologically active compounds

2009 ◽  
Vol 20 (19) ◽  
pp. 2226-2229 ◽  
Author(s):  
Ramón Badorrey ◽  
María D. Díaz-de-Villegas ◽  
José A. Gálvez
Keyword(s):  
Asymmetric Synthesis ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Active Compounds

Use of chiral auxiliaries in the asymmetric synthesis of biologically active compounds: A review

Chirality ◽  
2019 ◽  
Vol 31 (10) ◽  
pp. 776-812 ◽  
Author(s):  
Gaspar Diaz‐Muñoz ◽  
Izabel Luzia Miranda ◽  
Suélen Karine Sartori ◽  
Daniele Cristina Rezende ◽  
Marisa Alves Nogueira Diaz
Keyword(s):  
Asymmetric Synthesis ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Chiral Auxiliaries ◽  
Active Compounds

Recent Advances in the Catalytic Asymmetric Construction of Phosphorus-Substituted Quaternary Carbon Stereocenters

Synthesis ◽  
2017 ◽  
Vol 50 (03) ◽  
pp. 440-469 ◽  
Author(s):  
Long Chen
Keyword(s):  
Asymmetric Synthesis ◽  
Reaction Mechanisms ◽  
Recent Progress ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Quaternary Carbon ◽  
Active Compounds ◽  
Catalytic Asymmetric Synthesis ◽  
Stereogenic Centers ◽  
Catalytic Asymmetric

Phosphorus-substituted quaternary carbon stereocenters exist widely in drugs and biologically active compounds. Catalytic asymmetric synthesis of such quaternary carbon stereogenic centers is of significant importance, with four synthetic strategies being established. This review summarizes the recent progress in this field, including the advantages and limitations of each strategy, briefly discusses the reaction mechanisms and challenges, and outlines synthetic opportunities still open.1 Introduction2 Asymmetric Hydrophosphonylation3 Asymmetric Electrophilic Phosphination4 Asymmetric Functionalization of P-Substituted Methine Compounds5 Asymmetric Addition to α-Keto- or α-Ketiminophosphonates6 Conclusion

Catalytic, Enantioselective Diamination of Alkenes

Synthesis ◽  
2021 ◽  
Author(s):  
Scott E. Denmark ◽  
Zhong-Lin Tao
Keyword(s):  
Asymmetric Synthesis ◽  
Reaction Mechanisms ◽  
Short Review ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Active Compounds ◽  
Recent Advances ◽  
Vicinal Diamines

AbstractEnantioselective diamination of alkenes represents one of the most straightforward methods to access enantioenriched, vicinal diamines, which are not only frequently encountered in biologically active compounds, but also have broad applications in asymmetric synthesis. Although the analogous dihydroxylation of olefins is well-established, the development of enantioselective olefin diamination lags far behind. Nevertheless, several successful methods have been developed that operate by different reaction mechanisms, including a cycloaddition pathway, a two-electron redox pathway, and a radical pathway. This short review summarizes recent advances and identifies limitations, with the aim of inspiring further developments in this area.1 Introduction2 Cycloaddition Pathway3 Two-Electron Redox Pathway3.1 Pd(0)/Pd(II) Diamination3.2 Pd(II)/Pd(IV) Diamination3.3 I(I)/I(III) Diamination3.4 Se(II)/Se(IV) Diamination4 One-Electron Radical Pathway4.1 Cu-Catalyzed Diamination4.2 Fe-Catalyzed Diamination5 Summary and Outlook

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