ChemInform Abstract: A Convenient Synthesis of 1,2,4-Triazolo(4,3,2-o,p)(1,3)diazocino(4,5- b)quinoxalines via a 1,3-Dipolar Cycloaddition Reaction and a Ring Transformation.

ChemInform ◽  
2010 ◽  
Vol 24 (19) ◽  
pp. no-no
Author(s):  
Y. KURASAWA ◽  
N. YOSHISHIBA ◽  
T. KUREYAMA ◽  
T. OKANO ◽  
A. TAKADA ◽  
...  
Keyword(s):  
Cycloaddition Reaction ◽  
Dipolar Cycloaddition ◽  
Ring Transformation ◽  
Convenient Synthesis

A convenient synthesis of 1,2,4-triazolo[4,3,2-o,p]-[1,3]diazocino[4,5-b]quinoxalinesviaa 1,3-dipolar cycloaddition reaction and a ring transformation

1992 ◽  
Vol 29 (6) ◽  
pp. 1653-1656 ◽  
Author(s):  
Yoshihisa Kurasawa ◽  
Noriko Yoshishiba ◽  
Tomomi Kureyama ◽  
Tomoko Okano ◽  
Atsushi Takada ◽  
...  
Keyword(s):  
Cycloaddition Reaction ◽  
Dipolar Cycloaddition ◽  
Ring Transformation ◽  
Convenient Synthesis

Copper-catalyzed Convenient Synthesis and SAR Studies of Substituted-1,2,3-triazole as Antimicrobial Agents

2018 ◽  
Vol 16 (1) ◽  
pp. 3-10
Author(s):  
Aniket P. Sarkate ◽  
Kshipra S. Karnik ◽  
Pravin S. Wakte ◽  
Ajinkya P. Sarkate ◽  
Ashwini V. Izankar ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Antifungal Activity ◽  
Antimicrobial Agents ◽  
Cycloaddition Reaction ◽  
Dipolar Cycloaddition ◽  
One Pot ◽  
Triazole Derivatives ◽  
Sar Studies ◽  
Convenient Synthesis ◽  
Antibacterial And Antifungal

Background:A novel copper-catalyzed synthesis of substituted-1,2,3-triazole derivatives has been developed and performed by Huisgen 1,3-dipolar cycloaddition reaction of azides with alkynes. The reaction is one-pot multicomponent.Objective:We state the advancement and execution of a methodology allowing for the synthesis of some new substituted 1,2,3-triazole analogues with antimicrobial activity.Methods:A series of triazole derivatives was synthesized by Huisgen 1,3-dipolar cycloaddition reaction of azides with alkynes. The structures of the synthesized compounds were elucidated and confirmed by 1H NMR, IR, MS and elemental analysis. All the synthesized compounds were tested for their antimicrobial activity against a series of strains of Bacillus subtilis, Staphylococcus aureus and Escherichia coli for antibacterial activity and against the strains of Candida albicans, Aspergillus flavus and Aspergillus nigar for antifungal activity, respectively.Results and Conclusion:From the antimicrobial data, it was observed that all the newly synthesized compounds showed good to moderate level of antibacterial and antifungal activity.

A Convenient Synthesis of Fused Tetrahydroazocines from Acenaphthylene-1,2-dione, Proline, and Acetylenic Esters

Synlett ◽  
2017 ◽  
Vol 29 (05) ◽  
pp. 635-639 ◽  
Author(s):  
Issa Yavari ◽  
Leila Baoosi ◽  
Mohammad Halvagar
Keyword(s):  
Cycloaddition Reaction ◽  
Azomethine Ylides ◽  
Dipolar Cycloaddition ◽  
X Ray Diffraction ◽  
Acetylenic Esters ◽  
X Ray ◽  
Convenient Synthesis ◽  
Boat Form ◽  
Twist Boat

A synthesis of dialkyl (12E,14E)-7-oxo-10,11-dihydro-7H,9H-azocino[2,1-a]benzo[de]isoquinoline-13,14-dicarboxylates through a 1,3-dipolar cycloaddition reaction of azomethine ylides, generated in situ from proline and acenaphthylene-1,2-dione, with dialkyl acetylenedicarboxylates is described. According to the X-ray diffraction data, the tetrahydroazocine ring has a rigid twist-boat form with approximate local C2 symmetry.

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