ChemInform Abstract: UCE1022, a New Antitumor Antibiotic with Topoisomerase I Mediated DNA Cleavage Activity, from Paecilomyces.

ChemInform ◽  
2010 ◽  
Vol 26 (11) ◽  
pp. no-no
Author(s):  
N. FUJII ◽  
Y. YAMASHITA ◽  
K. ANDO ◽  
T. AGATSUMA ◽  
Y. SAITOH ◽  
...  
Keyword(s):  
Dna Cleavage ◽  
Topoisomerase I ◽  
Antitumor Antibiotic ◽  
Cleavage Activity ◽  
Dna Cleavage Activity

scholarly journals UCE6, A new antitumor antibiotic with topoisomerase I mediated DNA cleavage activity, from actinomycetes.

1993 ◽  
Vol 46 (7) ◽  
pp. 1173-1174 ◽  
Author(s):  
NOBORU FUJII ◽  
YOSHINORI YAMASHITA ◽  
SHIGERU CHIBA ◽  
YOUICHI UOSAKI ◽  
YUTAKA SAITOH ◽  
...  
Keyword(s):  
Dna Cleavage ◽  
Topoisomerase I ◽  
Antitumor Antibiotic ◽  
Cleavage Activity ◽  
Dna Cleavage Activity

scholarly journals UCE1022, a new antitumor antibiotic with topoisomerase I mediated DNA cleavage activity, from Paecilomyces.

1994 ◽  
Vol 47 (8) ◽  
pp. 949-951 ◽  
Author(s):  
NOBORU FUJII ◽  
YOSHINORI YAMASHITA ◽  
KATSUHIKO ANDO ◽  
TSUTOMU AGATSUMA ◽  
YUTAKA SAITOH ◽  
...  
Keyword(s):  
Dna Cleavage ◽  
Topoisomerase I ◽  
Antitumor Antibiotic ◽  
Cleavage Activity ◽  
Dna Cleavage Activity

scholarly journals The geometry of DNA supercoils modulates the DNA cleavage activity of human topoisomerase I

2010 ◽  
Vol 39 (3) ◽  
pp. 1014-1022 ◽  
Author(s):  
A. C. Gentry ◽  
S. Juul ◽  
C. Veigaard ◽  
B. R. Knudsen ◽  
N. Osheroff
Keyword(s):  
Dna Cleavage ◽  
Topoisomerase I ◽  
Cleavage Activity ◽  
Dna Cleavage Activity

scholarly journals UCT4B, a new antitumor antibiotic with topoisomerase II mediated DNA cleavage activity.

1993 ◽  
Vol 46 (2) ◽  
pp. 235-240 ◽  
Author(s):  
YOUICHI UOSAKI ◽  
SHO-ZOU KAWADA ◽  
HIROFUMI NAKANO ◽  
YUTAKA SAITOH ◽  
HIROSHI SANO
Keyword(s):  
Dna Cleavage ◽  
Topoisomerase Ii ◽  
Antitumor Antibiotic ◽  
Cleavage Activity ◽  
Dna Cleavage Activity

scholarly journals Saintopin, a new antitumor antibiotic with topoisomerase II dependent DNA cleavage activity, from Paecilomyces.

1990 ◽  
Vol 43 (10) ◽  
pp. 1344-1346 ◽  
Author(s):  
YOSHINORI YAMASHITA ◽  
YUTAKA SAITOH ◽  
KATSUHIKO ANDO ◽  
KEIICHI TAKAHASHI ◽  
HIROE OHNO ◽  
...  
Keyword(s):  
Dna Cleavage ◽  
Topoisomerase Ii ◽  
Antitumor Antibiotic ◽  
Cleavage Activity ◽  
Dna Cleavage Activity

Synthesis and Characterisation of RuII Polypyridyl Complexes: DNA-Binding, Photocleavage, and Topoisomerase I and II Inhibitory Activity

2013 ◽  
Vol 66 (11) ◽  
pp. 1406 ◽  
Author(s):  
Xiaojun He ◽  
Guang Yang ◽  
Xiaonan Sun ◽  
Lingjun Xie ◽  
Lifeng Tan
Keyword(s):  
Dna Binding ◽  
Dna Cleavage ◽  
Topoisomerase I ◽  
Mixed Ligand ◽  
Dual Inhibitor ◽  
Cleavage Activity ◽  
Dna Cleavage Activity ◽  
Pbr322 Dna ◽  
Dna Strand ◽  
Strand Passage

Two mixed-ligand ruthenium(ii) complexes [Ru(phen)2(cptcp)]2+ (Ru1; phen = 1,10-phenanthroline, cptcp = 2-(4-carbazol-9-yl-phenyl)-1H-1,3,7,8-tetraaza-cyclopenta-[l]-phenanthrene) and [Ru(phen)2(btcpc)]2+ (Ru2; btcpc = 9-butyl-6-(1H-1,3,7,8-tetraaza-cyclo-cyclopenta-[l]-phenanthren-2-yl)-9H-carbazole-3-carbaldehyde) have been synthesised and characterised. The DNA-binding behaviours of the two complexes have been investigated by using spectroscopic and viscosity measurements. Results suggest that the two complexes bind to DNA by intercalation. The photocleavage of plasmid pBR322 DNA indicates that Ru1 exhibits more effective DNA cleavage activity in comparison to that exhibited by Ru2 under the same conditions, and different cleavage mechanisms are determined. Topoisomerase inhibition and DNA strand passage assay confirm that Ru1 may act as an efficient dual inhibitor of topoisomerases I and II, whereas Ru2 may only act as a single inhibitor of topoisomerases II.

scholarly journals Bacterial Cell Killing Mediated by Topoisomerase I DNA Cleavage Activity

2005 ◽  
Vol 280 (46) ◽  
pp. 38489-38495 ◽  
Author(s):  
Bokun Cheng ◽  
Shikha Shukla ◽  
Sarinnapha Vasunilashorn ◽  
Somshuvra Mukhopadhyay ◽  
Yuk-Ching Tse-Dinh
Keyword(s):  
Dna Cleavage ◽  
Bacterial Cell ◽  
Topoisomerase I ◽  
Cell Killing ◽  
Cleavage Activity ◽  
Dna Cleavage Activity

scholarly journals UCT-4B, a new antitumor antibiotic with topoisomerase II mediated DNA cleavage activity, from streptomyces sp.

1992 ◽  
Vol 45 (7) ◽  
pp. 1182-1184 ◽  
Author(s):  
SHO-ZOU KAWADA ◽  
YOSHINORI YAMASHITA ◽  
YOUICHI UOSAKI ◽  
KATSUSHIGE GOMI ◽  
TOSHIAKI IWASAKI ◽  
...  
Keyword(s):  
Dna Cleavage ◽  
Topoisomerase Ii ◽  
Antitumor Antibiotic ◽  
Streptomyces Sp ◽  
Cleavage Activity ◽  
Dna Cleavage Activity
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