ChemInform Abstract: Peptide Synthesis via Fragment Condensation

ChemInform ◽  
2010 ◽  
Vol 26 (22) ◽  
pp. no-no
Author(s):  
R. NYFELER
Keyword(s):  
Peptide Synthesis ◽  
Fragment Condensation

Ynamide: A New Coupling Reagent for Amide and Peptide Synthesis

Synlett ◽  
2017 ◽  
Vol 28 (14) ◽  
pp. 1663-1670 ◽  
Author(s):  
Long Hu ◽  
Junfeng Zhao
Keyword(s):  
Peptide Synthesis ◽  
Phosphonium Salt ◽  
Peptide Fragment ◽  
Coupling Reagents ◽  
Development History ◽  
Coupling Reagent ◽  
History Of ◽  
Fragment Condensation ◽  
Carbodiimide Coupling ◽  
Guanidinium Salt

The discovery and application of ynamide coupling reagents is highlighted with a brief summary of the development history of coupling reagents in amide and peptide synthesis. As novel coupling reagents, ynamides are not only effective for simple amide and dipeptide synthesis but also can be used for peptide fragment condensation. More importantly, no racemization was detected during the activation of α-chiral carboxylic acids by employing ynamide coupling reagents.1 Introduction2 Carbodiimide Coupling Reagents3 Uronium/Guanidinium Salt Coupling Reagents4 Phosphonium Salt Coupling Reagents5 Ethoxyacetylene as a Coupling Reagent6 Ynamine Coupling Reagents7 Ynamide Coupling Reagents8 Summary and Outlook

scholarly journals Solid Phase Peptide Synthesis by Oxidation-Reduction Condensation. Synthesis of LH–RH by Fragment Condensation on Solid Support

1973 ◽  
Vol 46 (10) ◽  
pp. 3240-3247 ◽  
Author(s):  
Rei Matsueda ◽  
Hiroshi Maruyama ◽  
Eiichi Kitazawa ◽  
Hidekuni Takahagi ◽  
Teruaki Mukaiyama
Keyword(s):  
Peptide Synthesis ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Solid Support ◽  
Oxidation Reduction ◽  
Fragment Condensation ◽  
Lh Rh
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