ChemInform Abstract: Efficient Synthesis of 1-Amino-2-naphthalenecarboxylic Acid Derivatives via a Sequential Michael Addition/Enolate-Nitrile Coupling Route and Its Application to Facile Preparation of 9-Amino Analogues of Arylnaphthofuranone Lignans.

A convenient method for synthesizing 3-amino-1,5-benzodiazepine-2-one via the Michael addition reaction of o-phenylenediamine with dehydroalanine ester derivatives, followed by cyclization, was developed. This simple method was used to obtain a variety of N-substituted 3-amino-1,5-benzodiazepine-2-ones in one pot with good yields.

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A Highly Efficient Synthesis of Lamellarins K and L by the Michael Addition/Ring-Closure Reaction of Benzyldihydroisoquinoline Derivatives with Ethoxycarbonyl-β-nitrostyrenes

Angewandte Chemie ◽

10.1002/ange.200352043 ◽

2004 ◽

Vol 116 (7) ◽

pp. 884-886 ◽

Cited By ~ 10

Author(s):

Poonsakdi Ploypradith ◽

Chulabhorn Mahidol ◽

Poolsak Sahakitpichan ◽

Siriporn Wongbundit ◽

Somsak Ruchirawat

Keyword(s):

Michael Addition ◽

Ring Closure ◽

Efficient Synthesis ◽

Highly Efficient ◽

The Michael Addition

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An Efficient Synthesis of Chiral Diamines with Rigid Backbones: Application in Enantioselective Michael Addition of Malonates to Nitroalkenes

Organic Letters ◽

10.1021/ol901776n ◽

2009 ◽

Vol 11 (20) ◽

pp. 4536-4539 ◽

Cited By ~ 45

Author(s):

Qiming Zhu ◽

Hanmin Huang ◽

Dengjian Shi ◽

Zhiqiang Shen ◽

Chungu Xia

Keyword(s):

Michael Addition ◽

Efficient Synthesis ◽

Chiral Diamines

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Facile and Efficient Synthesis of Dendrimers and One-Pot Preparation of Dendritic–Linear Polymer Conjugates via a Single Chemistry: Utilization of Kinetically Selective Thiol–Michael Addition Reactions

Macromolecules ◽

10.1021/ma501418r ◽

2014 ◽

Vol 47 (15) ◽

pp. 4894-4900 ◽

Cited By ~ 29

Author(s):

Shunsuke Chatani ◽

Maciej Podgórski ◽

Chen Wang ◽

Christopher N. Bowman

Keyword(s):

Michael Addition ◽

Linear Polymer ◽

Addition Reactions ◽

Efficient Synthesis ◽

One Pot ◽

Polymer Conjugates

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Efficient synthesis of chiral cyclic acetals by metal and Brønsted acid co-catalyzed enantioselective four-component cascade reactions

Chemical Communications ◽

10.1039/c3cc49063g ◽

2014 ◽

Vol 50 (17) ◽

pp. 2196-2198 ◽

Cited By ~ 20

Author(s):

Lin Qiu ◽

Xin Guo ◽

Chaoqun Ma ◽

Huang Qiu ◽

Shunying Liu ◽

...

Keyword(s):

Michael Addition ◽

Cascade Reactions ◽

Bronsted Acid ◽

Brønsted Acid ◽

Efficient Synthesis ◽

Mannich Reactions ◽

Cyclic Acetals ◽

Brönsted Acid

Four-component Mannich reactions subsequently followed by an intramolecular oxo-Michael addition were developed to efficiently produce chiral cyclic acetals with high diastereoselectivity and enantioselectivity.

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