ChemInform Abstract: Synthesis of Coumarin-Based, Esterase-Sensitive Cyclic Prodrugs of Opioid Peptides with Enhanced Membrane Permeability and Enzymic Stability

Synthesis of Coumarin-Based, Esterase-Sensitive Cyclic Prodrugs of Opioid Peptides with Enhanced Membrane Permeability and Enzymatic Stability

Peptidomimetics Protocols ◽

10.1385/0-89603-517-4:71 ◽

2003 ◽

pp. 71-86

Author(s):

Binghe Wang ◽

Daxian Shan ◽

Wei Wang ◽

Huijuan Zhang ◽

Olafur Gudmundsson ◽

...

Keyword(s):

Membrane Permeability ◽

Opioid Peptides ◽

Enzymatic Stability ◽

The effect of conformation of the acyloxyalkoxy‐based cyclic prodrugs of opioid peptides on their membrane permeability

10.1034/j.1399-3011.1999.00077.x ◽

1999 ◽

Vol 53 (4) ◽

pp. 403-413 ◽

Cited By ~ 24

Author(s):

O.S. Gudmundsson ◽

D.G. Vander Velde ◽

S.D.S. Jois ◽

A. Bak ◽

T.J. Siahaan ◽

...

Keyword(s):

Membrane Permeability ◽

Opioid Peptides ◽

Synthesis and evaluation of the physicochemical properties of esterase‐sensitive cyclic prodrugs of opioid peptides using an (acyloxy)alkoxy linker

10.1034/j.1399-3011.1999.00070.x ◽

1999 ◽

Vol 53 (4) ◽

pp. 393-402 ◽

Cited By ~ 23

Author(s):

A. Bak ◽

O.S. Gudmundsson ◽

S. Gangwar ◽

G.J. Friis ◽

T.J. Siahaan ◽

...

Keyword(s):

Physicochemical Properties ◽

Opioid Peptides ◽

ChemInform Abstract: Synthesis and Evaluation of Novel Coumarin-Based Esterase-Sensitive Cyclic Prodrugs of Peptidomimetic RGD Analogues with Improved Membrane Permeability.

ChemInform ◽

10.1002/chin.199930175 ◽

2010 ◽

Vol 30 (30) ◽

pp. no-no

Author(s):

Binghe Wang ◽

Wei Wang ◽

Gian P. Camenisch ◽

Jennifer Elmo ◽

Huijuan Zhang ◽

...

Keyword(s):

Membrane Permeability ◽

Significant differences in the disposition of cyclic prodrugs of opioid peptides in rats and guinea pigs following IV administration

Journal of Pharmaceutical Sciences ◽

10.1002/jps.20476 ◽

2005 ◽

Vol 94 (12) ◽

pp. 2676-2687 ◽

Cited By ~ 10

Author(s):

Bianca M. Liederer ◽

Kimthoa t. Phan ◽

Hui ouyang ◽

Ronald T. Borchardt

Keyword(s):

Opioid Peptides ◽

Guinea Pigs ◽

Synthesis and evaluation of the physicochemical properties of esterase‐sensitive cyclic prodrugs of opioid peptides using coumarinic acid and phenylpropionic acid linkers

10.1034/j.1399-3011.1999.00071.x ◽

1999 ◽

Vol 53 (4) ◽

pp. 370-382 ◽

Cited By ~ 41

Author(s):

B. Wang ◽

W. Wang ◽

H. Zhang ◽

D. Shan ◽

K. Nimkar ◽

...

Keyword(s):

Physicochemical Properties ◽

Opioid Peptides ◽

Phenylpropionic Acid ◽

The effect of conformation on the membrane permeation of coumarinic acid‐ and phenylpropionic acid‐based cyclic prodrugs of opioid peptides

10.1034/j.1399-3011.1999.00076.x ◽

1999 ◽

Vol 53 (4) ◽

pp. 383-392 ◽

Cited By ~ 34

Author(s):

O.S. Gudmundsson ◽

S. D. S. Jois ◽

D. G. Vander Velde ◽

T.J. Siahaan ◽

R.T. Borchardt ◽

...

Keyword(s):

Opioid Peptides ◽

Membrane Permeation ◽

Phenylpropionic Acid ◽

Pharmacochemistry Library - Proceedings XIVth International Symposium on Medicinal Chemistry ◽

Novel esterase-sensitive cyclic prodrugs of a model hexapeptide having enhanced membrane permeability and enzymatic stability

10.1016/s0165-7208(97)80050-5 ◽

1997 ◽

pp. 27-34 ◽

Cited By ~ 2

Author(s):

Sanjeev Gangwar ◽

Giovanni M. Pauletti ◽

Binghe Wang ◽

Teruna J. Siahaan ◽

Valentino J. Stella ◽

...

Keyword(s):

Membrane Permeability ◽

Enzymatic Stability ◽

Novel Esterase ◽

Effects of Amino Acid Chirality and the Chemical Linker on the Cell Permeation Characteristics of Cyclic Prodrugs of Opioid Peptides

Journal of Medicinal Chemistry ◽

10.1021/jm050277f ◽

2006 ◽

Vol 49 (4) ◽

pp. 1261-1270 ◽

Cited By ~ 11

Author(s):

Bianca M. Liederer ◽

Tarra Fuchs ◽

David Vander Velde ◽

Teruna J. Siahaan ◽

Ronald T. Borchardt

Keyword(s):

Amino Acid ◽

Opioid Peptides ◽

Stability of Oxymethyl-Modified Coumarinic Acid Cyclic Prodrugs of Diastereomeric Opioid Peptides in Biological Media from Various Animal Species Including Human

Journal of Pharmaceutical Sciences ◽

10.1002/jps.20452 ◽

2005 ◽

Vol 94 (10) ◽

pp. 2198-2206 ◽

Cited By ~ 23

Author(s):

Bianca M. Liederer ◽

Ronald T. Borchardt

Keyword(s):

Opioid Peptides ◽

Animal Species ◽

Biological Media ◽