cyclic prodrugs Recently Published Documents

Evaluation of Novel Acyclic Nucleoside Phosphonates against Human and Animal Gammaherpesviruses Revealed an Altered Metabolism of Cyclic Prodrugs upon Epstein-Barr Virus Reactivation in P3HR-1 Cells

Journal of Virology ◽

10.1128/jvi.02231-13 ◽

2013 ◽

Vol 87 (22) ◽

pp. 12422-12432 ◽

Cited By ~ 14

Author(s):

N. Coen ◽

S. Duraffour ◽

L. Naesens ◽

M. Krecmerova ◽

J. Van den Oord ◽

...

Keyword(s):

Epstein Barr Virus ◽

Virus Reactivation ◽

Barr Virus ◽

Acyclic Nucleoside Phosphonates ◽

Altered Metabolism ◽

Acyclic Nucleoside ◽

Epstein Barr ◽

Cyclic Prodrugs ◽

Epstein Barr Virus Reactivation

Factors that Restrict the Cell Permeation of Cyclic Prodrugs of an Opioid Peptide, Part 3: Synthesis of Analogs Designed to have Improved Stability to Oxidative Metabolism

10.1002/jps.23109 ◽

2012 ◽

Vol 101 (9) ◽

pp. 3486-3499 ◽

Cited By ~ 5

Author(s):

Rebecca Nofsinger ◽

Tarra Fuchs-Knotts ◽

Ronald T. Borchardt

Keyword(s):

Oxidative Metabolism ◽

Opioid Peptide ◽

Improved Stability ◽

Factors that Restrict the Cell Permeation of Cyclic Prodrugs of an Opioid Peptide, Part 4: Characterization of the Biopharmaceutical and Physicochemical Properties of Two New Cyclic Prodrugs Designed to be Stable to Oxidative Metabolism by Cytochrome P-450 Enzymes in the Intestinal Mucosa

10.1002/jps.23079 ◽

2012 ◽

Vol 101 (9) ◽

pp. 3500-3510 ◽

Cited By ~ 6

Author(s):

Rebecca Nofsinger ◽

Ronald T. Borchardt

Keyword(s):

Physicochemical Properties ◽

Intestinal Mucosa ◽

Oxidative Metabolism ◽

Opioid Peptide ◽

Cyclic Prodrugs ◽

Cytochrome P 450

ChemInform Abstract: Synthesis and Evaluation of Novel Coumarin-Based Esterase-Sensitive Cyclic Prodrugs of Peptidomimetic RGD Analogues with Improved Membrane Permeability.

ChemInform ◽

10.1002/chin.199930175 ◽

2010 ◽

Vol 30 (30) ◽

pp. no-no

Author(s):

Binghe Wang ◽

Wei Wang ◽

Gian P. Camenisch ◽

Jennifer Elmo ◽

Huijuan Zhang ◽

...

Keyword(s):

Membrane Permeability ◽

ChemInform Abstract: Synthesis of Coumarin-Based, Esterase-Sensitive Cyclic Prodrugs of Opioid Peptides with Enhanced Membrane Permeability and Enzymic Stability

ChemInform ◽

10.1002/chin.200032251 ◽

2010 ◽

Vol 31 (32) ◽

pp. no-no

Author(s):

Binghe Wang ◽

Daxian Shan ◽

Wei Wang ◽

Huijuan Zhang ◽

Olafur Gudmundsson ◽

...

Keyword(s):

Membrane Permeability ◽

Opioid Peptides ◽

A comparison of the effects of p-glycoprotein inhibitors on the blood–brain barrier permeation of cyclic prodrugs of an opioid peptide (DADLE)

10.1002/jps.21585 ◽

2009 ◽

Vol 98 (6) ◽

pp. 2227-2236 ◽

Cited By ~ 18

Author(s):

Hui Ouyang ◽

Thomas E. Andersen ◽

Weiqing Chen ◽

Rebecca Nofsinger ◽

Bente Steffansen ◽

...

Keyword(s):

Blood Brain Barrier ◽

Opioid Peptide ◽

Brain Barrier ◽

P Glycoprotein ◽

Blood Brain ◽

Cyclic Prodrugs ◽

Glycoprotein Inhibitors

Factors that restrict intestinal cell permeation of cyclic prodrugs of an opioid peptide (DADLE): Part II. Role of metabolic enzymes in the intestinal mucosa

10.1002/jps.21424 ◽

2009 ◽

Vol 98 (1) ◽

pp. 349-361 ◽

Cited By ~ 5

Author(s):

Hui Ouyang ◽

Weiqing Chen ◽

Thomas E. Andersen ◽

Bente Steffansen ◽

Ronald T. Borchardt ◽

...

Keyword(s):

Intestinal Mucosa ◽

Metabolic Enzymes ◽

Opioid Peptide ◽

Intestinal Cell ◽

Factors that restrict the intestinal cell permeation of cyclic prodrugs of an opioid peptide (DADLE): Part I. Role of efflux transporters in the intestinal mucosa

10.1002/jps.21428 ◽

2009 ◽

Vol 98 (1) ◽

pp. 337-348 ◽

Cited By ~ 3

Author(s):

Thomas E. Andersen ◽

Bente Steffansen ◽

Ronald T. Borchardt ◽

Hui Ouyang ◽

Weiqing Chen

Keyword(s):

Intestinal Mucosa ◽

Opioid Peptide ◽

Intestinal Cell ◽

Efflux Transporters ◽

Effects of Amino Acid Chirality and the Chemical Linker on the Cell Permeation Characteristics of Cyclic Prodrugs of Opioid Peptides

Journal of Medicinal Chemistry ◽

10.1021/jm050277f ◽

2006 ◽

Vol 49 (4) ◽

pp. 1261-1270 ◽

Cited By ~ 11

Author(s):

Bianca M. Liederer ◽

Tarra Fuchs ◽

David Vander Velde ◽

Teruna J. Siahaan ◽

Ronald T. Borchardt

Keyword(s):

Amino Acid ◽

Opioid Peptides ◽