ChemInform Abstract: Substituted Imidazoles a Glucagon Receptor Antagonists.

ChemInform ◽  
2010 ◽  
Vol 33 (5) ◽  
pp. no-no
Author(s):  
Linda L. Chang ◽  
et al. et al.
Keyword(s):  
Receptor Antagonists ◽  
Glucagon Receptor

scholarly journals Synthesis and Anti‐Diabetic Activity of Novel Biphenylsulfonamides as Glucagon Receptor Antagonists

2021 ◽  
Author(s):  
Chang‐Yong Lee ◽  
Hojung Choi ◽  
Eun‐Young Park ◽  
Thi‐Thao‐Linh Nguyen ◽  
Han‐Joo Maeng ◽  
...  
Keyword(s):  
Receptor Antagonists ◽  
Glucagon Receptor

Proglucagon-Derived Peptides: Mechanisms of Action and Therapeutic Potential

Physiology ◽  
2005 ◽  
Vol 20 (5) ◽  
pp. 357-365 ◽  
Author(s):  
Elaine M Sinclair ◽  
Daniel J. Drucker
Keyword(s):  
Type 2 Diabetes ◽  
Human Disease ◽  
Clinical Relevance ◽  
Therapeutic Potential ◽  
Mechanisms Of Action ◽  
Receptor Antagonists ◽  
Glucagon Receptor ◽  
Receptor Agonists ◽  
Glucagon Like Peptide

Glucagon is used for the treatment of hypoglycemia, and glucagon receptor antagonists are under development for the treatment of type 2 diabetes. Moreover, glucagon-like peptide (GLP)-1 and GLP-2 receptor agonists appear to be promising therapies for the treatment of type 2 diabetes and intestinal disorders, respectively. This review discusses the physiological, pharmacological, and therapeutic actions of the proglucagon-derived peptides, with an emphasis on clinical relevance of the peptides for the treatment of human disease.

Discovery of novel, potent, selective, and orally active human glucagon receptor antagonists containing a pyrazole core

2011 ◽  
Vol 21 (1) ◽  
pp. 76-81 ◽  
Author(s):  
Dong-Ming Shen ◽  
Edward J. Brady ◽  
Mari R. Candelore ◽  
Qing Dallas-Yang ◽  
Victor D.-H. Ding ◽  
...  
Keyword(s):  
Receptor Antagonists ◽  
Glucagon Receptor ◽  
Orally Active

Direct observation (NMR) of the efficacy of glucagon receptor antagonists in murine liver expressing the human glucagon receptor

2006 ◽  
Vol 14 (5) ◽  
pp. 1506-1517 ◽  
Author(s):  
Sheila M. Cohen ◽  
Joseph L. Duffy ◽  
Corin Miller ◽  
Brian A. Kirk ◽  
Mari Rios Candelore ◽  
...  
Keyword(s):  
Direct Observation ◽  
Receptor Antagonists ◽  
Glucagon Receptor ◽  
Murine Liver

Discovery of novel, potent, and orally active spiro-urea human glucagon receptor antagonists

2005 ◽  
Vol 15 (20) ◽  
pp. 4564-4569 ◽  
Author(s):  
Dong-Ming Shen ◽  
Fengqi Zhang ◽  
Edward J. Brady ◽  
Mari Rios Candelore ◽  
Qing Dallas-Yang ◽  
...  
Keyword(s):  
Receptor Antagonists ◽  
Glucagon Receptor ◽  
Orally Active

Potent, orally absorbed glucagon receptor antagonists

1999 ◽  
Vol 9 (5) ◽  
pp. 641-646 ◽  
Author(s):  
Stephen E. de Laszlo ◽  
Candice Hacker ◽  
Bing Li ◽  
Dooseop Kim ◽  
Malcolm MacCoss ◽  
...  
Keyword(s):  
Receptor Antagonists ◽  
Glucagon Receptor

Human Glucagon Receptor Antagonists with Thiazole Cores. A Novel Series with Superior Pharmacokinetic Properties

2009 ◽  
Vol 52 (9) ◽  
pp. 2989-3000 ◽  
Author(s):  
Peter Madsen ◽  
János T. Kodra ◽  
Carsten Behrens ◽  
Erica Nishimura ◽  
Claus B. Jeppesen ◽  
...  
Keyword(s):  
Receptor Antagonists ◽  
Glucagon Receptor ◽  
Pharmacokinetic Properties

Discovery of thiophene-containing biaryl amide derivatives as novel glucagon receptor antagonists

2018 ◽  
Vol 92 (1) ◽  
pp. 1241-1254
Author(s):  
Jia Li ◽  
Yang Feng ◽  
Huihui Li ◽  
Shuangjie Shu ◽  
Antao Dai ◽  
...  
Keyword(s):  
Receptor Antagonists ◽  
Glucagon Receptor ◽  
Amide Derivatives
Sign in / Sign up

Export Citation Format

Share Document