Rational Design, Synthesis and Structure—Activity Relationships of a Cyclic Succinate Series of TNF-α Converting Enzyme Inhibitors. Part 1. Lead Identification.

10.1002/chin.200414160 ◽

2004 ◽

Vol 35 (14) ◽

Author(s):

Chu-Biao Xue ◽

et al. et al.

Keyword(s):

Rational Design ◽

Enzyme Inhibitors ◽

Converting Enzyme ◽

Converting Enzyme Inhibitors ◽

Design Synthesis ◽

Structure Activity Relationships ◽

Structure Activity ◽

Tnf Α ◽

Lead Identification

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Rational design, synthesis and structure–Activity relationships of a cyclic succinate series of TNF-α converting enzyme inhibitors. Part 1: lead identification

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2003.09.056 ◽

2003 ◽

Vol 13 (24) ◽

pp. 4293-4297 ◽

Author(s):

Chu-Biao Xue ◽

Xiaohua He ◽

John Roderick ◽

Ronald L. Corbett ◽

James J.-W. Duan ◽

...

Keyword(s):

Rational Design ◽

Enzyme Inhibitors ◽

Converting Enzyme ◽

Converting Enzyme Inhibitors ◽

Design Synthesis ◽

Structure Activity Relationships ◽

Structure Activity ◽

Tnf Α ◽

Lead Identification

Download Full-text

Rational Design, Synthesis and Structure—Activity Relationships of a Cyclic Succinate Series of TNF-α Converting Enzyme Inhibitors. Part 2. Lead Optimization.

10.1002/chin.200414161 ◽

2004 ◽

Vol 35 (14) ◽

Author(s):

Chu-Biao Xue ◽

et al. et al.

Keyword(s):

Rational Design ◽

Enzyme Inhibitors ◽

Lead Optimization ◽

Converting Enzyme ◽

Converting Enzyme Inhibitors ◽

Design Synthesis ◽

Structure Activity Relationships ◽

Structure Activity ◽

Download Full-text

Rational design, synthesis and structure–activity relationships of a cyclic succinate series of TNF-α converting enzyme inhibitors. Part 2: lead optimization

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2003.09.057 ◽

2003 ◽

Vol 13 (24) ◽

pp. 4299-4304 ◽

Author(s):

Chu-Biao Xue ◽

Xiaohua He ◽

John Roderick ◽

Ronald L Corbett ◽

James J.-W Duan ◽

...

Keyword(s):

Rational Design ◽

Enzyme Inhibitors ◽

Lead Optimization ◽

Converting Enzyme ◽

Converting Enzyme Inhibitors ◽

Design Synthesis ◽

Structure Activity Relationships ◽

Structure Activity ◽

Download Full-text

Synthesis and Structure—Activity Relationship of a Novel, Achiral Series of TNF-α Converting Enzyme Inhibitors.

10.1002/chin.200633145 ◽

2006 ◽

Vol 37 (33) ◽

Author(s):

John L. Gilmore ◽

et al. et al.

Keyword(s):

Enzyme Inhibitors ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Converting Enzyme ◽

Converting Enzyme Inhibitors ◽

Structure Activity ◽

Tnf Α ◽

Relationship Of

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ChemInform Abstract: Synthesis and Structure-Activity Relationships of Potent New Angiotensin Converting Enzyme Inhibitors Containing Saturated Bicyclic Amino Acids.

10.1002/chin.198747322 ◽

1987 ◽

Vol 18 (47) ◽

Author(s):

C. J. BLANKLEY ◽

J. S. KALTENBRONN ◽

D. E. DEJOHN ◽

A. WERNER ◽

L. R. BENNETT ◽

...

Keyword(s):

Amino Acids ◽

Angiotensin Converting Enzyme ◽

Enzyme Inhibitors ◽

Angiotensin Converting Enzyme Inhibitors ◽

Converting Enzyme ◽

Converting Enzyme Inhibitors ◽

Structure Activity Relationships ◽

Structure Activity

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Synthesis and structure–activity relationship of a novel, non-hydroxamate series of TNF-α converting enzyme inhibitors

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2007.05.100 ◽

2007 ◽

Vol 17 (16) ◽

pp. 4678-4682 ◽

Author(s):

John L. Gilmore ◽

Bryan W. King ◽

Naoyuki Asakawa ◽

Kimberly Harrison ◽

Andrew Tebben ◽

...

Keyword(s):

Enzyme Inhibitors ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Converting Enzyme ◽

Converting Enzyme Inhibitors ◽

Structure Activity ◽

Tnf Α ◽

Relationship Of

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Synthesis and structure activity relationships of potent new angiotensin converting enzyme inhibitors containing saturated bicyclic amino acids

Journal of Medicinal Chemistry ◽

10.1021/jm00389a006 ◽

1987 ◽

Vol 30 (6) ◽

pp. 992-998 ◽

Author(s):

C. J. Blankley ◽

J. S. Kaltenbronn ◽

D. E. DeJohn ◽

A. Werner ◽

L. R. Bennett ◽

...

Keyword(s):

Amino Acids ◽

Angiotensin Converting Enzyme ◽

Enzyme Inhibitors ◽

Angiotensin Converting Enzyme Inhibitors ◽

Converting Enzyme ◽

Converting Enzyme Inhibitors ◽

Structure Activity Relationships ◽

Structure Activity

Download Full-text

Synthesis and structure–activity relationship of a novel, achiral series of TNF-α converting enzyme inhibitors

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2006.02.015 ◽

2006 ◽

Vol 16 (10) ◽

pp. 2699-2704 ◽

Author(s):

John L. Gilmore ◽

Bryan W. King ◽

Cathy Harris ◽

Thomas Maduskuie ◽

Stephen E. Mercer ◽

...

Keyword(s):

Enzyme Inhibitors ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Converting Enzyme ◽

Converting Enzyme Inhibitors ◽

Structure Activity ◽

Tnf Α ◽

Relationship Of

Download Full-text

Synthesis and structure–activity relationship of a novel sulfone series of TNF-α converting enzyme inhibitors

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2004.06.049 ◽

2004 ◽

Vol 14 (17) ◽

pp. 4453-4459 ◽

Author(s):

Chu-Biao Xue ◽

Xiao-Tao Chen ◽

Xiaohua He ◽

John Roderick ◽

Ronald L. Corbett ◽

...

Keyword(s):

Enzyme Inhibitors ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Converting Enzyme ◽

Converting Enzyme Inhibitors ◽

Structure Activity ◽

Tnf Α ◽

Relationship Of

Download Full-text

Angiotensin-converting enzyme inhibitors: Synthesis and structure-activity relationships of potent N-benzyloxycarbonyl tripeptide inhibitors.

Chemical and Pharmaceutical Bulletin ◽

10.1248/cpb.37.2417 ◽

1989 ◽

Vol 37 (9) ◽

pp. 2417-2422 ◽

Author(s):

Tadahiro SAWAYAMA ◽

Masatoshi TSUKAMOTO ◽

Takashi SASAGAWA ◽

Kazuya NISHIMURA ◽

Ryuichi YAMAMOTO ◽

...

Keyword(s):

Angiotensin Converting Enzyme ◽

Enzyme Inhibitors ◽

Angiotensin Converting Enzyme Inhibitors ◽

Converting Enzyme ◽

Converting Enzyme Inhibitors ◽

Structure Activity Relationships ◽

Structure Activity

Download Full-text