ChemInform Abstract: Prenylated Flavonoids with PTP1B Inhibitory Activity from the Root Bark of Erythrina mildbraedii.

ChemInform ◽  
2008 ◽  
Vol 39 (28) ◽  
Author(s):  
JunPil Jang ◽  
MinKyun Na ◽  
Phuong Thien Thuong ◽  
Dieudonne Njamen ◽  
Joseph Tanyi Mbafor ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Root Bark ◽  
Prenylated Flavonoids

scholarly journals Prenylated Flavonoids with PTP1B Inhibitory Activity from the Root Bark of Erythrina mildbraedii

2008 ◽  
Vol 56 (1) ◽  
pp. 85-88 ◽  
Author(s):  
JunPil Jang ◽  
MinKyun Na ◽  
Phuong Thien Thuong ◽  
Dieudonné Njamen ◽  
Joseph Tanyi Mbafor ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Root Bark ◽  
Prenylated Flavonoids

Jatrophainolides A–C, new cembrane-type diterpenoids with PTP1B inhibitory activity from the root bark of Jatropha integerrima

2020 ◽  
Vol 36 ◽  
pp. 166-170
Author(s):  
Dong-Bo Zhang ◽  
Zheng Wang ◽  
Yan-Ni Liang ◽  
Jin-Gao Yu ◽  
Zhen Zhang ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Root Bark

New 2-arylbenzofurans from the root bark of Artocarpus gomezianus and their α-glucosidase inhibitory activity

2017 ◽  
Vol 33 (10) ◽  
pp. 1436-1441 ◽  
Author(s):  
Poomraphie Nuntawong ◽  
Virunh Kongkatitham ◽  
Kittisak Likhitwitayawuid ◽  
Wanwimon Mekboonsonglarp ◽  
Suchada Sukrong ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Root Bark

Four new prenylated flavonoids and xanthones from the root bark of Artocarpus nobilis

Fitoterapia ◽  
2008 ◽  
Vol 79 (1) ◽  
pp. 37-41 ◽  
Author(s):  
U.L.B. Jayasinghe ◽  
T.B. Samarakoon ◽  
B.M.M. Kumarihamy ◽  
N. Hara ◽  
Y. Fujimoto
Keyword(s):  
Root Bark ◽  
Prenylated Flavonoids

Two new prenylated flavonoids from the seeds of Psoralea corylifolia with their inhibitory activity on α-glucosidase

2020 ◽  
Vol 39 ◽  
pp. 64-67
Author(s):  
Wen-Ting Fei ◽  
Jian-Jun Zhang ◽  
Ru-Ying Tang ◽  
Na Yue ◽  
Xue Zhou ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Psoralea Corylifolia ◽  
Prenylated Flavonoids

Diterpenoids from the Root Bark of Pinus massoniana and Evaluation of Their Phosphodiesterase Type 4D Inhibitory Activity

2020 ◽  
Vol 83 (4) ◽  
pp. 1229-1237 ◽  
Author(s):  
Yifan Fu ◽  
Xiaoyu Ding ◽  
Xianglei Zhang ◽  
Xingcheng Shao ◽  
Jihui Zhao ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Pinus Massoniana ◽  
Root Bark ◽  
Phosphodiesterase Type

scholarly journals Structure Related α-Glucosidase Inhibitory Activity and Molecular Docking Analyses of Phenolic Compounds From Paeonia Suffruticosa

2021 ◽  
Author(s):  
Po-Chun Chen ◽  
Bongani Sicelo Dlamini ◽  
Chiy-Rong Chen ◽  
Yueh-Hsiung Kuo ◽  
Wen-Ling Shih ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Phenolic Compounds ◽  
Inhibitory Activity ◽  
Inhibitory Effect ◽  
Docking Studies ◽  
Inhibition Mechanism ◽  
Root Bark ◽  
Paeonia Suffruticosa ◽  
Glucosidase Inhibitors

Abstract In the continuous search for α-glucosidase inhibitors, eleven phenolic compounds (1-11) were isolated from the root bark of Paeonia suffruticosa. Their α-glucosidase inhibitory activity and inhibition mechanism were investigated using an in vitro inhibition assay and molecular docking studies. Compounds 2, 5, 6, and 8-11 (IC50 between 290 and 431 µM) inhibited α-glucosidase more effectively than the reference compound acarbose (IC50=1463 ± 29.5 µM). Among them, compound 10 exhibited the highest α-glucosidase inhibitory effect with an IC50 value of 290.4 ± 9.6 µM. Compounds 2, 5, 9 10 and 11 were found to be competitive inhibitors, while compounds 6 and 8 were noncompetitive inhibitors of α-glucosidase. Computational analyses showed that the main binding forces between the compounds and the main residues were hydrogen bonds. The results indicated that these compounds had considerable α-glucosidase inhibitory activity.

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