ChemInform Abstract: Catalyst-Free 1,3-Dipolar Cycloaddition of 3-Nitrochromen with Sodium Azide: A Facile Method for the Synthesis of 4-Aryl-1,4-dihydrochromeno[4,3-d][1,2,3]triazole Derivatives.

ChemInform ◽  
2009 ◽  
Vol 40 (46) ◽  
Author(s):  
Pateliya Mujjamil Habib ◽  
B. Rama Raju ◽  
Veerababurao Kavala ◽  
Chun-Wei Kuo ◽  
Ching-Fa Yao
Keyword(s):  
Sodium Azide ◽  
Dipolar Cycloaddition ◽  
Triazole Derivatives ◽  
Catalyst Free

Catalyst-free 1,3-dipolar cycloaddition of 3-nitrochromen with sodium azide: a facile method for the synthesis of 4-aryl-1,4-dihydrochromeno[4,3-d][1,2,3]triazole derivatives

Tetrahedron ◽  
2009 ◽  
Vol 65 (29-30) ◽  
pp. 5799-5804 ◽  
Author(s):  
Pateliya Mujjamil Habib ◽  
B. Rama Raju ◽  
Veerababurao Kavala ◽  
Chun-Wei Kuo ◽  
Ching-Fa Yao
Keyword(s):  
Sodium Azide ◽  
Dipolar Cycloaddition ◽  
Triazole Derivatives ◽  
Catalyst Free

Synthesis of highly diversified 1,2,3-triazole derivatives via domino [3 + 2] azide cycloaddition and denitration reaction sequence

RSC Advances ◽  
2015 ◽  
Vol 5 (113) ◽  
pp. 93447-93451 ◽  
Author(s):  
Manickam Bakthadoss ◽  
Nagappan Sivakumar ◽  
Anthonisamy Devaraj ◽  
Polu Vijay Kumar
Keyword(s):  
Sodium Azide ◽  
Reaction Sequence ◽  
Triazole Derivatives ◽  
Catalyst Free ◽  
Excellent Yield

Synthesis of 1,2,3-triazoles via domino azide cycloaddition and denitration reaction sequence under catalyst free conditions is described. Sodium azide treatment of Baylis–Hillman adducts and their cyclic derivatives from nitro olefins gave the triazoles in excellent yield.

Synthesis and optical properties of novel 1,2,3-triazole derivatives possessing highly substituted imidazoles

2019 ◽  
Vol 43 (7-8) ◽  
pp. 262-267 ◽  
Author(s):  
Zarrin Ghasemi ◽  
Arezoo Mirzaie ◽  
Roqhayeh Arabzadeh ◽  
Zahra Fathi ◽  
Ameneh Abolghassemi Fakhree
Keyword(s):  
Optical Properties ◽  
Sodium Azide ◽  
Spectroscopic Data ◽  
Fluorescence Emission ◽  
The Other ◽  
Dipolar Cycloaddition ◽  
Optical Parameters ◽  
Terminal Alkynes ◽  
Triazole Derivatives ◽  
Propargyl Ether

Reactions of 1,4,5-triaryl-2-(4-bromomethyl)phenyl-imidazoles with sodium azide in acetone give the corresponding azidomethyl derivatives, which on 1,3-dipolar cycloaddition with various terminal alkynes in the presence of CuI afford novel 1,2,3-triazole products. On the other hand, treatment of 2,4,5-triaryl-1-(4-hydroxyphenyl)-imidazoles with propargyl chloride in the presence of a base gives the corresponding propargyl ether derivatives, which under CuI-catalyzed 1,3-dipolar cycloaddition with benzyl azide produce 1,2,3-triazole derivatives. All the products are characterized from their spectroscopic data and most are evaluated for fluorescence emission. The optical parameters of the studied products are also reported.

Copper-catalyzed Convenient Synthesis and SAR Studies of Substituted-1,2,3-triazole as Antimicrobial Agents

2018 ◽  
Vol 16 (1) ◽  
pp. 3-10
Author(s):  
Aniket P. Sarkate ◽  
Kshipra S. Karnik ◽  
Pravin S. Wakte ◽  
Ajinkya P. Sarkate ◽  
Ashwini V. Izankar ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Antifungal Activity ◽  
Antimicrobial Agents ◽  
Cycloaddition Reaction ◽  
Dipolar Cycloaddition ◽  
One Pot ◽  
Triazole Derivatives ◽  
Sar Studies ◽  
Convenient Synthesis ◽  
Antibacterial And Antifungal

Background:A novel copper-catalyzed synthesis of substituted-1,2,3-triazole derivatives has been developed and performed by Huisgen 1,3-dipolar cycloaddition reaction of azides with alkynes. The reaction is one-pot multicomponent.Objective:We state the advancement and execution of a methodology allowing for the synthesis of some new substituted 1,2,3-triazole analogues with antimicrobial activity.Methods:A series of triazole derivatives was synthesized by Huisgen 1,3-dipolar cycloaddition reaction of azides with alkynes. The structures of the synthesized compounds were elucidated and confirmed by 1H NMR, IR, MS and elemental analysis. All the synthesized compounds were tested for their antimicrobial activity against a series of strains of Bacillus subtilis, Staphylococcus aureus and Escherichia coli for antibacterial activity and against the strains of Candida albicans, Aspergillus flavus and Aspergillus nigar for antifungal activity, respectively.Results and Conclusion:From the antimicrobial data, it was observed that all the newly synthesized compounds showed good to moderate level of antibacterial and antifungal activity.

Regioselective Synthesis of Novel 4,4′-and 5,5′-bi-(1,2,4-triazole) Derivatives

2007 ◽  
Vol 2007 (8) ◽  
pp. 472-474 ◽  
Author(s):  
Ahmad M. Farag ◽  
Kamal M. Dawood ◽  
Nabila A. Khedr
Keyword(s):  
Regioselective Synthesis ◽  
Dipolar Cycloaddition ◽  
Cycloaddition Reactions ◽  
Triazole Derivatives

A regioselective synthesis is reported of a series of polysubstituted 1,2,4-triazoles and 4,4′- and 5,5′-bi-(1,2,4-triazoles) via 1,3-dipolar cycloaddition reactions of nitrilimines with some aza- and diaza-butadiene derivatives.

Catalyst-Free Synthesis of N-(1,7-Dioxotetrahydropyrazolo[1,2-a]pyrazol-2-yl)benzamide Derivatives by 1,3-Dipolar Cycloaddition and Rearrangement

Synlett ◽  
2014 ◽  
Vol 25 (08) ◽  
pp. 1093-1096 ◽  
Author(s):  
Yu Xu ◽  
Wenjing Liu ◽  
Xingxia Sun ◽  
Dapeng Lu ◽  
Lijuan Guo
Keyword(s):  
Dipolar Cycloaddition ◽  
Catalyst Free ◽  
Benzamide Derivatives
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